1. Soleimani A, Hasanzadeh Kiabi F, Emami Zeydi A, et al. Can white blood cell count be
used as a predictor of atrial fibrillation following cardiac surgery? A short literature review.
Anadolu Kardiyol Derg. 2014; 14(2): 216–217.
2. Gholipour Baradari A, Emami Zeydi A, Ghafari R, et al. A dou¬ble-blind randomized
clinical trial comparing different doses of magnesium in cardioplegic solution for prevention
of atrial fibril¬lation after coronary artery bypass graft surgery. Cardiovasc Ther. 2016; 34(4):
276–282.
3. Kazemi B, Akbarzadeh F, Safaei N, et al.: Prophylactic high-dose Oral-N-Acetylcysteine
does not prevent atrial fibrillation after heart surgery: a prospective double blind placebocontrolled
randomized clinical trial. Pacing Clin Electrophysiol 2013, 36:1211–1219.
4. Arfsten D, Johnson E, Thitoff A, et al. Impact of 30-day oral dosing with N-acetyl-Lcysteine
on Sprague-Dawley rat physiology. Int J Toxicol 2004;23:239—47.
5. Goettea A, Lendeckel U. Nonchannel drug targets in atrial fibrillation. Pharmacol Ther
2004, 102:17-36.
6. Eslami M, Badkoubeh RS, Mousavi M, et al. Oral ascorbic acid in combination with betablockers
is more effective than beta-blockers alone in the prevention of atrial fibrillation after
coronary artery baypas grafting. Tex Heart Inst J 2007;34:268—74.
7. Lertsburapa K, White CM, Kluger J, et al. Preoperative statins for the prevention of atrial
fibrillation after cardiothoracic surgery. J Thorac Cardiovasc Surg 2008;135:405—11.
8. Liu XH, Xu CY, Fan GH. Efficacy of N-acetylcysteine in preventing atrial fibrillation after
cardiac surgery:a meta-analysis of published randomized controlled trials. BMS
Cardiovascular Disorders 2014:14(52).
9. Baker W.L, Anglade M.W, Baker E.L. et al. Use of N-acetylcysteine to reduce postcardiothoracic
surgery complications: a meta-analysis. Eur J Cardio-Thoracic Surgery
35(2009): 521-527.
10. Gu WJ, Wu ZJ, Wang PF. et al. N-acetylcysteine supplementation for the prevention of
atrial fibrillation after cardiac surgery: a meta-analysis of eight randomized controlled trials.
BMC Cardiovascular Disorders 2012:12(10).
11. Ali-Hassan-Sayegh S, Mirhosseini S.J., Rezaeisadrabadia M, et al. Antioxidant
supplementations for prevention of atrial fibrillation after cardiac surgery: an updated
comprehensive systematic review and meta-analysis of 23 randomized controlled trials.
Interactive CardioVascular and Thoracic Surgery 18 (2014) 646–654.
12. Mathew JP, Fontes ML, Tudor IC, et al. A multicenter risk for atrial fibrillation after
cardiac surgery. JAMA 2004, 291, Investigators of the Ischemia Research and Education
Foundation; Multicenter Study of Perioperative Ischemia Research Group):1720-1729.
13. Cairns JA, Connolly S, McMurtry S, et al. Canadian Cardiovascular Society atrial
fibrillation guidelines 2010: prevention of stroke and systemic thromboembolism in atrial
fibrillation and flutter. Can J Cardiol 2011, 27:74–90.
14. Ozaydin M, Peker O, Erdogan D, et al. N-acetylcysteine for the prevention of
postoperative atrial fibrillation: a prospective, randomized, placebo-controlled pilot study. Eur
Heart J 2008, 29:625–631.
15. Soleimani A, Habibi M.R., Kiabi F.H., et al. The effect of intravenous N-acetylcysteine on
prevention of atrial fibrillation after coronary artery bypass graft surgery: a double-blind,
randomised, placebo-controlled trial. Kardiologia Polska 2018; 76, 1: 99–106.
16. Krzych LJ, Szurlej D, Bochenek A. Rationale for propofol use in cardiac surgery. J
Cardiothorac Vasc Anesth. 2009; 23(6): 878–885.
17. Wijeysundera DN, Beattie WS, Rao V, et al. N-acetylcysteine for preventing acute kidney
injury in cardiac surgery patients with pre-existing moderate renal insufficiency. Can J
Anaesth 2007, 54:872–881.
18. Peker O, Peker T, Erdogan D, et al. Effects of intravenous N-acetylcysteine on
periprocedural myocardial injury after on-pump coronary artery by-pass grafting. J
Cardiovasc Surg (Torino)2008, 49:527-531.
The effect of intravenous N-acetyl cysteine on the incidence of postoperative atrial fibrillation in coronary artery bypass graft surgery patients
Atrial fibrillation is the most frequent arrhythmia after open heart surgery. The aim of this study was to determine the effect of intravenous (IV) N-acetyl cys-teine (NAC) administration in the early postoperative period of coronary ar-tery bypass (CABG) surgery on the incidence of postoperative atrial fibrillation (POAF). A total of 60 patients who had undergone isolated CABG surgery be-tween June 2014 – July 2015 in our clinic included in this retrospective study. The patients divided into two groups: Group 1 (n=30) included the patients who had been administered standard saline solution infusion and Group 2 (n=30) included the patients who had been administered IV NAC (10mg/kg) infusion while they were under mechanical ventilation support. All patients were ad-ministrated oral 600 mg NAC once a day for 5 days after weaning from me-chanical ventilation support. The ECG’s were evaluated for POAF by the same cardiovascular surgeon who was blinded for patient groups. POAF was seen in 12 (40%) patients in Group 1 and 4 (13%) patients in Group 2. The POAF incidence was significantly higher in Group 1 (p=0.020). We think that admin-istration IV NAC is an effective way to prevent the POAF after CABG surgery.
1. Soleimani A, Hasanzadeh Kiabi F, Emami Zeydi A, et al. Can white blood cell count be
used as a predictor of atrial fibrillation following cardiac surgery? A short literature review.
Anadolu Kardiyol Derg. 2014; 14(2): 216–217.
2. Gholipour Baradari A, Emami Zeydi A, Ghafari R, et al. A dou¬ble-blind randomized
clinical trial comparing different doses of magnesium in cardioplegic solution for prevention
of atrial fibril¬lation after coronary artery bypass graft surgery. Cardiovasc Ther. 2016; 34(4):
276–282.
3. Kazemi B, Akbarzadeh F, Safaei N, et al.: Prophylactic high-dose Oral-N-Acetylcysteine
does not prevent atrial fibrillation after heart surgery: a prospective double blind placebocontrolled
randomized clinical trial. Pacing Clin Electrophysiol 2013, 36:1211–1219.
4. Arfsten D, Johnson E, Thitoff A, et al. Impact of 30-day oral dosing with N-acetyl-Lcysteine
on Sprague-Dawley rat physiology. Int J Toxicol 2004;23:239—47.
5. Goettea A, Lendeckel U. Nonchannel drug targets in atrial fibrillation. Pharmacol Ther
2004, 102:17-36.
6. Eslami M, Badkoubeh RS, Mousavi M, et al. Oral ascorbic acid in combination with betablockers
is more effective than beta-blockers alone in the prevention of atrial fibrillation after
coronary artery baypas grafting. Tex Heart Inst J 2007;34:268—74.
7. Lertsburapa K, White CM, Kluger J, et al. Preoperative statins for the prevention of atrial
fibrillation after cardiothoracic surgery. J Thorac Cardiovasc Surg 2008;135:405—11.
8. Liu XH, Xu CY, Fan GH. Efficacy of N-acetylcysteine in preventing atrial fibrillation after
cardiac surgery:a meta-analysis of published randomized controlled trials. BMS
Cardiovascular Disorders 2014:14(52).
9. Baker W.L, Anglade M.W, Baker E.L. et al. Use of N-acetylcysteine to reduce postcardiothoracic
surgery complications: a meta-analysis. Eur J Cardio-Thoracic Surgery
35(2009): 521-527.
10. Gu WJ, Wu ZJ, Wang PF. et al. N-acetylcysteine supplementation for the prevention of
atrial fibrillation after cardiac surgery: a meta-analysis of eight randomized controlled trials.
BMC Cardiovascular Disorders 2012:12(10).
11. Ali-Hassan-Sayegh S, Mirhosseini S.J., Rezaeisadrabadia M, et al. Antioxidant
supplementations for prevention of atrial fibrillation after cardiac surgery: an updated
comprehensive systematic review and meta-analysis of 23 randomized controlled trials.
Interactive CardioVascular and Thoracic Surgery 18 (2014) 646–654.
12. Mathew JP, Fontes ML, Tudor IC, et al. A multicenter risk for atrial fibrillation after
cardiac surgery. JAMA 2004, 291, Investigators of the Ischemia Research and Education
Foundation; Multicenter Study of Perioperative Ischemia Research Group):1720-1729.
13. Cairns JA, Connolly S, McMurtry S, et al. Canadian Cardiovascular Society atrial
fibrillation guidelines 2010: prevention of stroke and systemic thromboembolism in atrial
fibrillation and flutter. Can J Cardiol 2011, 27:74–90.
14. Ozaydin M, Peker O, Erdogan D, et al. N-acetylcysteine for the prevention of
postoperative atrial fibrillation: a prospective, randomized, placebo-controlled pilot study. Eur
Heart J 2008, 29:625–631.
15. Soleimani A, Habibi M.R., Kiabi F.H., et al. The effect of intravenous N-acetylcysteine on
prevention of atrial fibrillation after coronary artery bypass graft surgery: a double-blind,
randomised, placebo-controlled trial. Kardiologia Polska 2018; 76, 1: 99–106.
16. Krzych LJ, Szurlej D, Bochenek A. Rationale for propofol use in cardiac surgery. J
Cardiothorac Vasc Anesth. 2009; 23(6): 878–885.
17. Wijeysundera DN, Beattie WS, Rao V, et al. N-acetylcysteine for preventing acute kidney
injury in cardiac surgery patients with pre-existing moderate renal insufficiency. Can J
Anaesth 2007, 54:872–881.
18. Peker O, Peker T, Erdogan D, et al. Effects of intravenous N-acetylcysteine on
periprocedural myocardial injury after on-pump coronary artery by-pass grafting. J
Cardiovasc Surg (Torino)2008, 49:527-531.
Coşkun Sungur, E., Altınay, L., & Buyukates, M. (2020). The effect of intravenous N-acetyl cysteine on the incidence of postoperative atrial fibrillation in coronary artery bypass graft surgery patients. Journal of Experimental and Clinical Medicine, 36(3), 81-85.
AMA
Coşkun Sungur E, Altınay L, Buyukates M. The effect of intravenous N-acetyl cysteine on the incidence of postoperative atrial fibrillation in coronary artery bypass graft surgery patients. J. Exp. Clin. Med. Şubat 2020;36(3):81-85.
Chicago
Coşkun Sungur, Elif, Levent Altınay, ve Mustafa Buyukates. “The Effect of Intravenous N-Acetyl Cysteine on the Incidence of Postoperative Atrial Fibrillation in Coronary Artery Bypass Graft Surgery Patients”. Journal of Experimental and Clinical Medicine 36, sy. 3 (Şubat 2020): 81-85.
EndNote
Coşkun Sungur E, Altınay L, Buyukates M (01 Şubat 2020) The effect of intravenous N-acetyl cysteine on the incidence of postoperative atrial fibrillation in coronary artery bypass graft surgery patients. Journal of Experimental and Clinical Medicine 36 3 81–85.
IEEE
E. Coşkun Sungur, L. Altınay, ve M. Buyukates, “The effect of intravenous N-acetyl cysteine on the incidence of postoperative atrial fibrillation in coronary artery bypass graft surgery patients”, J. Exp. Clin. Med., c. 36, sy. 3, ss. 81–85, 2020.
ISNAD
Coşkun Sungur, Elif vd. “The Effect of Intravenous N-Acetyl Cysteine on the Incidence of Postoperative Atrial Fibrillation in Coronary Artery Bypass Graft Surgery Patients”. Journal of Experimental and Clinical Medicine 36/3 (Şubat 2020), 81-85.
JAMA
Coşkun Sungur E, Altınay L, Buyukates M. The effect of intravenous N-acetyl cysteine on the incidence of postoperative atrial fibrillation in coronary artery bypass graft surgery patients. J. Exp. Clin. Med. 2020;36:81–85.
MLA
Coşkun Sungur, Elif vd. “The Effect of Intravenous N-Acetyl Cysteine on the Incidence of Postoperative Atrial Fibrillation in Coronary Artery Bypass Graft Surgery Patients”. Journal of Experimental and Clinical Medicine, c. 36, sy. 3, 2020, ss. 81-85.
Vancouver
Coşkun Sungur E, Altınay L, Buyukates M. The effect of intravenous N-acetyl cysteine on the incidence of postoperative atrial fibrillation in coronary artery bypass graft surgery patients. J. Exp. Clin. Med. 2020;36(3):81-5.