Are serum lipid and androgen levels different in women with natural or surgical menopause?

Yıl 2020, Cilt: 37 Sayı: 2, 53 - 56, 06.04.2020

Canan Soyer Banuhan Şahin Samettin Çelik Bugra Sahin Şafak Hatırnaz

Öz

Menopausal status is associated with the type of menopausal onset. The aim of this study was to investigate whether serum lipid and androgen levels are different in women with natural or surgical menopause. This retrospective case control study was conducted with 376 postmenopausal women with natural onset and 144 postmenopausal women with surgical onset. Each woman was assessed in terms of serum glucose, lipid and androgen levels. The mean serum glucose, cholesterol, triglyceride, HDL, LDL, VLDL and testosterone levels in the surgical menopause group were almost similar to those of the natural meno- pause group (p=0.510, p=0.873, p=0.807, p=0.950, p=0.807, p=0.972, p=0.086, p=0.778, respectively). The mean serum DHEAS levels in the natural meno- pause group were statistically higher in comparison with the surgical meno- pause group (p=0.044). Serum lipid levels in postmenopausal women are not different in terms of the type of menopause onset. Serum androgen levels were decreased more in surgical menopause with lower levels of DHEAS associated with surgical onset.

Anahtar Kelimeler

androgen, lipid, natural menopause, surgical menopause

Destekleyen Kurum

Samsun Women and Children's Health Research and Training Hospital

Proje Numarası

GOKA/2019/3/9

Kaynakça

• Referans 1: Carr, M.C., Kim, K.H., Zambon, A., Mitchell, E.S., Woods, N.F., Casazza, C.P., Purnell, J.Q., Hokanson, J.E., Brunzell, J.D., Schwartz, R.S., 2000. Changes in LDL density across the menopausal transition. J. Investig. Med. 48, 245-250.
• Referans 2: Castracane, V.D., Kraemer, G.R., Ogden, B.W., Kraemer, R., 2006. Interrelationships of serum estradiol, estrone, and estrone sulfate, adiposity, biochemical bone markers, and leptin in post-menopausal women. Maturitas. 53, 217-225.
• Referans 3: Celik, H., Gurates, B., Yavuz, A., Nurkalem, C., Hanay, F., Kavak, B., 2009. The effect of hysterectomy and bilaterally salpingo-oophorectomy on sexual function in postmenopausal women. Maturitas. 61, 358-363.
• Referans 4: Davison, S.L., Bell, R., Donath, S., Montalto, J.G., Davis, S.R., 2005. Androgen levels in adult females: changes with age, menopause and oophorectomy. J. Clin. Endocrinol. Metab. 90, 3847-3853.
• Referans 5: Elective and risk-reducing salpingooophorectomy. 2008. ACOG practice bulletin no. 89. Obstet. Gynecol. 111, 231 (reaffirmed: 2014).
• Referans 6: Farahmand. M., Ramezani. T.F., Bahri. K.M., Noroozzadeh. M., Azizi. F., 2015. Surgical menopause versus natural menopause and cardio-metabolic disturbances: A 12-year population-based cohort study. J. Endocrinol. Invest. 38, 761-767.
• Referans 7: Fogle, R., Stanczyk, F., Zhang, X., Paulson, R.J., 2007. Ovarian androgen production in postmenopausal women. J. Clin. Endocrinol. Metab. 92, 3040-3043.
• Referans 8: Gallicchio, L., Whiteman, M.K., Tomic, D., Miller, K.P., Langenberg, P., Flaws, J.A., 2006. Type of menopause, patterns of hormone therapy use, and hot flashes. Fertil. Steril. 85, 1432-1440.
• Referans 9: Kulak, J., Urbanetz, A.A., Kulak, C.A., Borba, V.Z., Boguszewski, C.L., 2009. Serum androgen concentrations and bone mineral density in postmenopausal ovariectomized and non-ovariectomized women. Arq. Bras. Endocrinol. Metabol. 53, 1033–1039.
• Referans 10: Landgren, B.M., Collins, A., Csemiczky, G., Burger, H.G., Baksheev, L., Robertson, DM., 2004. Menopause transition: annual changes in serum hormonal patterns over the menstrual cycle in women during a nine-year period prior to menopause. J. Clin. Endocrinol. Metab. 89, 2763–2769.
• Referans 11: Lasley, B.L., Santoro, N., Randolf, J.F., Gold, E.B., Crawford, S., Weiss, G., McConnell, D.S., Sowers, M.F., 2002. The relationship of circulating dehydroepiandrosterone, testosterone, and estradiol to stages of the menopausal transition and ethnicity. J. Clin. Endocrinol. Metab. 87, 3760-3767.
• Referans 12: Lobo, R.A., 2007. Surgical menopause and cardiovascular risks. Menopause. 14, 562-566.
• Referans 13: Matsui, S., Yasui, T., Tani, A., Kato, T., Kunimi, K., Uemura, H., Kuwahara, A., Matsuzaki, T., Irahara, M., 2012. Association of circulating adiponectin with testosterone in women during the menopausal transition. Maturitas. 73, 255-60.
• Referans 14: Ozdemir, S., Celik, C., Gorkemli, H., Kiyici, A., Kaya, B., 2009. Compared effects of surgical and natural menopause on climacteric symptoms, osteoporosis, and metabolic syndrome. Int. J. Gynaecol. Obstet. 106, 57–61.
• Referans 15: Rodriguez, M., Shoupe, D., 2015. Surgical Menopause. Endocrinol. Metab. Clin. North. Am. 44, 531-542.
• Referans 16: Soules, M.R., Sherman, S., Parrott, E., Rebar, R., Santoro, N., Utian, W., Woods, N., 2001. “Executive summary: Stages of Reproductive Aging Workshop (STRAW),” Fertility and Sterility. 76, 874–888.
• Referans 17: Taylor, H.S., Kagan, R., Altomare, C.J., Cort, S., Bushmakin, A.G., Abraham, L., 2017. Menopause. 24, 27-34.
• Referans 18: Wang, Q., Ferreira, D.L.S., Nelson, S.M., Sattar, N., Ala-Korpela, M., Lawlor, D.A., 2018. Metabolic characterization of menopause: cross-sectional and longitudinal evidence. BMC. Med. 16, 17.
• Referans 19: Yoshida, T., Takahashi, K., Yamatani, H., Takata, K., Kurachi, H., 2011. Impact of surgical menopause on lipid and bone metabolism. Climacteric. 14, 445-452.