Association of anteroseptal hypokinesia after myocardial infarction with LDLR variation: A cross-sectional case-control study

Year 2020, Volume: 37 Issue: 3, 87 - 95, 30.04.2020

Pegah Pourzargham Mahboobeh Azadi Monireh Ataollahi Hamed Fouladseresht Shahdad Khosropanah Mehrnoosh Doroudchi

Abstract

Cholesterol-rich LDL (LDL-C) is a major atherogenic lipoprotein. Elevated content of LDL-C in serum is associated with the higher risk of atherosclerosis. The plasma LDL-C level is regulated by LDL receptor. The T allele of rs2228671 in LDLR may be associated with decreased LDL-C levels. We investigated the association of rs2228671 of LDLR with myocardial infarction (MI) in people from Fars province of Iran. In this study 248 cases with MI and 256 healthy blood donors were tested for their rs2228671 LDLR polymorphism by PCR-RFLP method. The CC genotype of the rs2228671 single nucleotide polymorphism tended to be more common in patients while TT showed a higher frequency in the control group. Patients with anteroseptal hypokinesia had a significantly higher frequency of the CC genotype compared with other patients (p= 0.04, OR 8.217 and 95% CI 0.4755 to 142). Also frequency of C allele was increased as compared with that of the T allele in patients with anetroseptal hypokinesia (p=0.05, OR 7.637 and 95% CI 0.4367 to 124.6). There was also a significant increase of CT genotype in patients with abnormal heart rate (p=0.014). A significantly higher frequency of the CC genotype in patients with anetroseptal hypokinesia and its decrease in patients with abnormal heart rate suggest a complex relationship between LDLR variants and complications of MI.

Keywords

Low density lipoprotein receptor, polymorphism, single nucleotide, myocardial Infarction, hypokinesia

Supporting Institution

Shiraz University of Medical Sciences

Project Number

94-9301 and 93-7326

Thanks

The authors thank all the individuals (patients, blood donors, and hospital staff) who participated in this study. This work was supported by grants from Shiraz University of Medical Sciences (grant numbers: 94-9301 and 93-7326), Shiraz, Iran. The codes of ethical approval of these projects are: IR.SUMS.REC.1394.s96 and IR.SUMS.REC.1393.7326.

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