Araştırma Makalesi
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Yıl 2021, Cilt: 38 Sayı: 2, 82 - 87, 03.04.2021

Öz

Destekleyen Kurum

YOK

Proje Numarası

YOK

Teşekkür

YOK

Kaynakça

  • Abdel-Daim, M.M., El-Ela, F.I.A., Alshahrani, F.K., Bin-Jumah, M., Al-Zharani, M., Almutairi, B., Alyousif, M.S., Bungau, S., Aleya, L., Alkahtani, S., 2020. Protective effects of thymoquinone against acrylamide-induced liver, kidney and brain oxidative damage in rats. Environmental Science and Pollution Research. 1-9.
  • Algarra, M., Fernandes, A., Mateus, N., de Freitas, V., da Silva, J.C.E., Casado, J., 2014. Anthocyanin profile and antioxidant capacity of black carrots (Daucus carota L. ssp. sativus var. atrorubens Alef.) from Cuevas Bajas, Spain. Journal of Food Composition and Analysis. 33, 71-76.
  • Atwa, A.H., 2020. A study of The Possible Protective Effects of Garlic Oil and Rosemary Extract Against Some Toxic effects of Acrylamid on Adult Male Albino Rats. Zagazig Journal of Forensic Medicine. 18, 68-91.
  • Bradford, M.M., 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical biochemistry. 72, 248-254.
  • Dasari, S., Ganjayi, M.S., Gonuguntla, S., Ramineedu, K., Konda, P.Y., Meriga, B., 2018a. Assessment of biomarkers in acrylamide-induced neurotoxicity and brain histopathology in rat. Journal of Applied Biology & Biotechnology Vol. 6, 79-86.
  • Dasari, S., Ganjayi, M.S., Meriga, B., 2018b. Glutathione S-transferase is a good biomarker in acrylamide induced neurotoxicity and genotoxicity. Interdisciplinary Toxicology. 11, 115-121.
  • Di, L., 2019. The impact of carboxylesterases in drug metabolism and pharmacokinetics. Current drug metabolism. 20, 91-102.
  • Dortaj, H., Yadegari, M., Abad, M.H.S., Sarcheshmeh, A.A., Anvari, M., 2018. Stereological method for assessing the effect of vitamin C administration on the reduction of acrylamide-induced neurotoxicity. Basic and Clinical Neuroscience. 9, 27.
  • Ellman, G.L., Courtney, K.D., Andres Jr, V., Featherstone, R.M., 1961. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochemical pharmacology. 7, 88-95.
  • Erdemli, Z., Erdemli, M.E., Turkoz, Y., Yigitcan, B., Aladag, M.A., Cigremis, Y., Cırık, R.H., Altinoz, E., Bag, H.G., 2020. Vitamin E effects on developmental disorders in fetuses and cognitive dysfunction in adults following acrylamide treatment during pregnancy. Biotechnic & Histochemistry. 1-9.
  • Garcia‐Herrera, P., Pérez‐Rodríguez, M.L., Aguilera‐Delgado, T., Labari‐Reyes, M.J., Olmedilla‐Alonso, B., Camara, M., de Pascual‐Teresa, S., 2016. Anthocyanin profile of red fruits and black carrot juices, purees and concentrates by HPLC‐DAD‐ESI/MS‐QTOF. International journal of food science & technology. 51, 2290-2300.
  • Guo, J., Cao, X., Hu, X., Li, S., Wang, J., 2020. The anti-apoptotic, antioxidant and anti-inflammatory effects of curcumin on acrylamide-induced neurotoxicity in rats. BMC Pharmacology and Toxicology. 21, 1-10.
  • Habig, W.H., Pabst, M.J., Jakoby, W.B., 1974. Glutathione S-transferases the first enzymatic step in mercapturic acid formation. Journal of biological Chemistry. 249, 7130-7139.
  • Kamiloglu, S., Van Camp, J., Capanoglu, E., 2018. Black carrot polyphenols: Effect of processing, storage and digestion—An overview. Phytochemistry Reviews. 17, 379-395.
  • Khoo, H.E., Azlan, A., Tang, S.T., Lim, S.M., 2017. Anthocyanidins and anthocyanins: colored pigments as food, pharmaceutical ingredients, and the potential health benefits. Food & nutrition research. 61, 1361779.
  • Kopanska, M., Czech, J., Zagata, P., Dobrek, L., Thor, P., Formicki, G., 2017. Effect of the different doses of acrylamide on acetylocholinoesterase activity, thiol groups, malondialdehyde concentrations in hypothalamus and selected muscles of mice. J Physiol Pharmacol. 68, 565-571.
  • Lee, S., Park, H.R., Lee, J.Y., Cho, J.-H., Song, H.M., Kim, A.H., Lee, W., Lee, Y., Chang, S.-C., Kim, H.S., 2018. Learning, memory deficits, and impaired neuronal maturation attributed to acrylamide. Journal of Toxicology and Environmental Health, Part A. 81, 254-265.
  • Mizgier, P., Kucharska, A.Z., Sokół-Łętowska, A., Kolniak-Ostek, J., Kidoń, M., Fecka, I., 2016. Characterization of phenolic compounds and antioxidant and anti-inflammatory properties of red cabbage and purple carrot extracts. Journal of Functional Foods. 21, 133-146.
  • Moron, M.S., Depierre, J.W., Mannervik, B., 1979. Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver. Biochimica et biophysica acta (BBA)-general subjects. 582, 67-78.
  • Nousiainen, U., Törrönen, R., 1984. Differentiation of microsomal and cytosolic carboxylesterases in the rat liver by in vivo and in vitro inhibition. General pharmacology. 15, 223.
  • Özmen, M., Dominguez, S., Fairbrother, A., 1998. Effects of dietary azinphos methyl on selected plasma and tissue biomarkers of the gray-tailed vole. Bulletin of environmental contamination and toxicology. 60, 194-201.
  • Placer, Z.A., Cushman, L.L., Johnson, B.C., 1966. Estimation of product of lipid peroxidation (malonyl dialdehyde) in biochemical systems. Analytical biochemistry. 16, 359-364.
  • Shrivastava, S., Uthra, C., Reshi, M., Singh, A., Yadav, D., Shukla, S., 2018. Protective effect of hesperetin against acrylamide induced acute toxicity in rats.
  • Soto-Mancera, F., Arellano, J., Albendín, M., 2020. Carboxylesterase in Sparus aurata: Characterisation and sensitivity to organophosphorus pesticides and pharmaceutical products. Ecological Indicators. 109, 105603.
  • Tabeshpour, J., Mehri, S., Abnous, K., Hosseinzadeh, H., 2019. Neuroprotective effects of thymoquinone in acrylamide-induced peripheral nervous system toxicity through MAPKinase and apoptosis pathways in rat. Neurochemical research. 44, 1101-1112.
  • Ulusoy, A., Tamer, C.E., 2019. Determination of suitability of black carrot (Daucus carota L. spp. sativus var. atrorubens Alef.) juice concentrate, cherry laurel (Prunus laurocerasus), blackthorn (Prunus spinosa) and red raspberry (Rubus ideaus) for kombucha beverage production. Journal of Food Measurement and Characterization. 13, 1524-1536.
  • Yi, C., Xie, K., Song, F., Yu, L., Zhao, X., Li, G., Yu, S., 2006. The changes of cytoskeletal proteins in plasma of acrylamide-induced rats. Neurochemical research. 31, 751-757.

An investigation of histopathologic and morphometric effect of black carrot juice on acrylamid induced neurotoxicity

Yıl 2021, Cilt: 38 Sayı: 2, 82 - 87, 03.04.2021

Öz

Acrylamide is a substance known to have neurotoxic effects. It has high exposure due to its widespread use in the industrial field and its occurrence in foods. This situation has led the scientific world to identify natural components that can eliminate these effects of acrylamide. This experimental study was planned to examine the effect of black carrot containing high bioavailability flavonoids on the neurotoxicity induced by acrylamide. The rats used in the study were divided into 4 groups. Group 1 was used as a control group. Acrylamide was applied to the second group. Third group was formed the rats which black carrot was applied in addition to acrylamide application. Rats in the 4th group were given only black carrots. Biochemical, histopathological and histomorphometric analyzes were performed on rats that were sacrificed at the end of the experiment. Significant histopathological degenerations were observed in the acrylamide group. Although a volumetric decrease was observed in all brain regions examined histomothometrically, this decrease was not statistically significant. The MDA and GST levels of the acrylamide group showed a significant increase compared to the control group. It was observed that GSH, CAE and AChE levels increased in the acrylamide and black carrot group compared to the acrylamide group. The results of our research indicate that black carrot has healing effects on the neurotoxicity induced by acrylamide.

Proje Numarası

YOK

Kaynakça

  • Abdel-Daim, M.M., El-Ela, F.I.A., Alshahrani, F.K., Bin-Jumah, M., Al-Zharani, M., Almutairi, B., Alyousif, M.S., Bungau, S., Aleya, L., Alkahtani, S., 2020. Protective effects of thymoquinone against acrylamide-induced liver, kidney and brain oxidative damage in rats. Environmental Science and Pollution Research. 1-9.
  • Algarra, M., Fernandes, A., Mateus, N., de Freitas, V., da Silva, J.C.E., Casado, J., 2014. Anthocyanin profile and antioxidant capacity of black carrots (Daucus carota L. ssp. sativus var. atrorubens Alef.) from Cuevas Bajas, Spain. Journal of Food Composition and Analysis. 33, 71-76.
  • Atwa, A.H., 2020. A study of The Possible Protective Effects of Garlic Oil and Rosemary Extract Against Some Toxic effects of Acrylamid on Adult Male Albino Rats. Zagazig Journal of Forensic Medicine. 18, 68-91.
  • Bradford, M.M., 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical biochemistry. 72, 248-254.
  • Dasari, S., Ganjayi, M.S., Gonuguntla, S., Ramineedu, K., Konda, P.Y., Meriga, B., 2018a. Assessment of biomarkers in acrylamide-induced neurotoxicity and brain histopathology in rat. Journal of Applied Biology & Biotechnology Vol. 6, 79-86.
  • Dasari, S., Ganjayi, M.S., Meriga, B., 2018b. Glutathione S-transferase is a good biomarker in acrylamide induced neurotoxicity and genotoxicity. Interdisciplinary Toxicology. 11, 115-121.
  • Di, L., 2019. The impact of carboxylesterases in drug metabolism and pharmacokinetics. Current drug metabolism. 20, 91-102.
  • Dortaj, H., Yadegari, M., Abad, M.H.S., Sarcheshmeh, A.A., Anvari, M., 2018. Stereological method for assessing the effect of vitamin C administration on the reduction of acrylamide-induced neurotoxicity. Basic and Clinical Neuroscience. 9, 27.
  • Ellman, G.L., Courtney, K.D., Andres Jr, V., Featherstone, R.M., 1961. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochemical pharmacology. 7, 88-95.
  • Erdemli, Z., Erdemli, M.E., Turkoz, Y., Yigitcan, B., Aladag, M.A., Cigremis, Y., Cırık, R.H., Altinoz, E., Bag, H.G., 2020. Vitamin E effects on developmental disorders in fetuses and cognitive dysfunction in adults following acrylamide treatment during pregnancy. Biotechnic & Histochemistry. 1-9.
  • Garcia‐Herrera, P., Pérez‐Rodríguez, M.L., Aguilera‐Delgado, T., Labari‐Reyes, M.J., Olmedilla‐Alonso, B., Camara, M., de Pascual‐Teresa, S., 2016. Anthocyanin profile of red fruits and black carrot juices, purees and concentrates by HPLC‐DAD‐ESI/MS‐QTOF. International journal of food science & technology. 51, 2290-2300.
  • Guo, J., Cao, X., Hu, X., Li, S., Wang, J., 2020. The anti-apoptotic, antioxidant and anti-inflammatory effects of curcumin on acrylamide-induced neurotoxicity in rats. BMC Pharmacology and Toxicology. 21, 1-10.
  • Habig, W.H., Pabst, M.J., Jakoby, W.B., 1974. Glutathione S-transferases the first enzymatic step in mercapturic acid formation. Journal of biological Chemistry. 249, 7130-7139.
  • Kamiloglu, S., Van Camp, J., Capanoglu, E., 2018. Black carrot polyphenols: Effect of processing, storage and digestion—An overview. Phytochemistry Reviews. 17, 379-395.
  • Khoo, H.E., Azlan, A., Tang, S.T., Lim, S.M., 2017. Anthocyanidins and anthocyanins: colored pigments as food, pharmaceutical ingredients, and the potential health benefits. Food & nutrition research. 61, 1361779.
  • Kopanska, M., Czech, J., Zagata, P., Dobrek, L., Thor, P., Formicki, G., 2017. Effect of the different doses of acrylamide on acetylocholinoesterase activity, thiol groups, malondialdehyde concentrations in hypothalamus and selected muscles of mice. J Physiol Pharmacol. 68, 565-571.
  • Lee, S., Park, H.R., Lee, J.Y., Cho, J.-H., Song, H.M., Kim, A.H., Lee, W., Lee, Y., Chang, S.-C., Kim, H.S., 2018. Learning, memory deficits, and impaired neuronal maturation attributed to acrylamide. Journal of Toxicology and Environmental Health, Part A. 81, 254-265.
  • Mizgier, P., Kucharska, A.Z., Sokół-Łętowska, A., Kolniak-Ostek, J., Kidoń, M., Fecka, I., 2016. Characterization of phenolic compounds and antioxidant and anti-inflammatory properties of red cabbage and purple carrot extracts. Journal of Functional Foods. 21, 133-146.
  • Moron, M.S., Depierre, J.W., Mannervik, B., 1979. Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver. Biochimica et biophysica acta (BBA)-general subjects. 582, 67-78.
  • Nousiainen, U., Törrönen, R., 1984. Differentiation of microsomal and cytosolic carboxylesterases in the rat liver by in vivo and in vitro inhibition. General pharmacology. 15, 223.
  • Özmen, M., Dominguez, S., Fairbrother, A., 1998. Effects of dietary azinphos methyl on selected plasma and tissue biomarkers of the gray-tailed vole. Bulletin of environmental contamination and toxicology. 60, 194-201.
  • Placer, Z.A., Cushman, L.L., Johnson, B.C., 1966. Estimation of product of lipid peroxidation (malonyl dialdehyde) in biochemical systems. Analytical biochemistry. 16, 359-364.
  • Shrivastava, S., Uthra, C., Reshi, M., Singh, A., Yadav, D., Shukla, S., 2018. Protective effect of hesperetin against acrylamide induced acute toxicity in rats.
  • Soto-Mancera, F., Arellano, J., Albendín, M., 2020. Carboxylesterase in Sparus aurata: Characterisation and sensitivity to organophosphorus pesticides and pharmaceutical products. Ecological Indicators. 109, 105603.
  • Tabeshpour, J., Mehri, S., Abnous, K., Hosseinzadeh, H., 2019. Neuroprotective effects of thymoquinone in acrylamide-induced peripheral nervous system toxicity through MAPKinase and apoptosis pathways in rat. Neurochemical research. 44, 1101-1112.
  • Ulusoy, A., Tamer, C.E., 2019. Determination of suitability of black carrot (Daucus carota L. spp. sativus var. atrorubens Alef.) juice concentrate, cherry laurel (Prunus laurocerasus), blackthorn (Prunus spinosa) and red raspberry (Rubus ideaus) for kombucha beverage production. Journal of Food Measurement and Characterization. 13, 1524-1536.
  • Yi, C., Xie, K., Song, F., Yu, L., Zhao, X., Li, G., Yu, S., 2006. The changes of cytoskeletal proteins in plasma of acrylamide-induced rats. Neurochemical research. 31, 751-757.
Toplam 27 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Experimental Research
Yazarlar

Gülru Esen 0000-0002-8848-3988

Miraç Uçkun 0000-0002-9018-8515

Ahmet Özkaya 0000-0002-0173-3084

Ertan Yoloğlu 0000-0002-9730-9471

Ebru Annaç 0000-0001-9726-5846

Hıdır Pekmez 0000-0002-4916-7675

Seda Uludağ 0000-0003-1952-4587

Proje Numarası YOK
Yayımlanma Tarihi 3 Nisan 2021
Gönderilme Tarihi 23 Aralık 2020
Kabul Tarihi 16 Ocak 2021
Yayımlandığı Sayı Yıl 2021 Cilt: 38 Sayı: 2

Kaynak Göster

APA Esen, G., Uçkun, M., Özkaya, A., Yoloğlu, E., vd. (2021). An investigation of histopathologic and morphometric effect of black carrot juice on acrylamid induced neurotoxicity. Journal of Experimental and Clinical Medicine, 38(2), 82-87.
AMA Esen G, Uçkun M, Özkaya A, Yoloğlu E, Annaç E, Pekmez H, Uludağ S. An investigation of histopathologic and morphometric effect of black carrot juice on acrylamid induced neurotoxicity. J. Exp. Clin. Med. Nisan 2021;38(2):82-87.
Chicago Esen, Gülru, Miraç Uçkun, Ahmet Özkaya, Ertan Yoloğlu, Ebru Annaç, Hıdır Pekmez, ve Seda Uludağ. “An Investigation of Histopathologic and Morphometric Effect of Black Carrot Juice on Acrylamid Induced Neurotoxicity”. Journal of Experimental and Clinical Medicine 38, sy. 2 (Nisan 2021): 82-87.
EndNote Esen G, Uçkun M, Özkaya A, Yoloğlu E, Annaç E, Pekmez H, Uludağ S (01 Nisan 2021) An investigation of histopathologic and morphometric effect of black carrot juice on acrylamid induced neurotoxicity. Journal of Experimental and Clinical Medicine 38 2 82–87.
IEEE G. Esen, M. Uçkun, A. Özkaya, E. Yoloğlu, E. Annaç, H. Pekmez, ve S. Uludağ, “An investigation of histopathologic and morphometric effect of black carrot juice on acrylamid induced neurotoxicity”, J. Exp. Clin. Med., c. 38, sy. 2, ss. 82–87, 2021.
ISNAD Esen, Gülru vd. “An Investigation of Histopathologic and Morphometric Effect of Black Carrot Juice on Acrylamid Induced Neurotoxicity”. Journal of Experimental and Clinical Medicine 38/2 (Nisan 2021), 82-87.
JAMA Esen G, Uçkun M, Özkaya A, Yoloğlu E, Annaç E, Pekmez H, Uludağ S. An investigation of histopathologic and morphometric effect of black carrot juice on acrylamid induced neurotoxicity. J. Exp. Clin. Med. 2021;38:82–87.
MLA Esen, Gülru vd. “An Investigation of Histopathologic and Morphometric Effect of Black Carrot Juice on Acrylamid Induced Neurotoxicity”. Journal of Experimental and Clinical Medicine, c. 38, sy. 2, 2021, ss. 82-87.
Vancouver Esen G, Uçkun M, Özkaya A, Yoloğlu E, Annaç E, Pekmez H, Uludağ S. An investigation of histopathologic and morphometric effect of black carrot juice on acrylamid induced neurotoxicity. J. Exp. Clin. Med. 2021;38(2):82-7.