The relationship between disease severity and GDF-15 in individuals diagnosed with obstructive sleep apnea syndrome

Yıl 2022, Cilt: 39 Sayı: 1, 47 - 50, 01.01.2022

Yalçın Boduroğlu Duygu Zorlu Bilal İlanbey Arzu Ertürk

Öz

Obstructive sleep apnea syndrome (OSAS) is characterized with interruption of sleep with apnea attacks and is associated with various diseases such as metabolic syndrome. GDF-15 (Growth differentiation factor 15) is a cytokine belonging to the transforming growth factor – β superfamily and it has been found to be associated with chronic heart failure, acute pulmonary embolism, and acute attacks of chronic obstructive pulmonary disease (COPD). It was aimed to evaluate the relationship between disease severity and mean GDF-15 in patients diagnosed with OSAS. Our study was carried out with 75 patients with OSAS. GDF-15 levels were checked by in the morning fasting blood test. Among the 75 patients, 27 constituted the mild, 22 constituted the moderate and 26 constituted the severe OSAS groups. The mean ages of the patients were not significantly different between groups (53.17±10, 54.61±10.2 and 53.5±11.6 respectively; p>0,05). GDF-15 levels were not significantly different between groups separately (p>0.05). There was only a weak positive relationship between GDF-15 and NREM and REM (p<0.05). In our study, it was revealed that there was no significant relationship between the OSAS severity groups and GDF-15. Our determination of a positive relationship with NREM and REM may have been related to reduction of minute ventilation experienced in OSAS-diagnosed patients, tachycardic fluctuations, their more severe nature and increased right ventricular pressure. Consequently, our current knowledge indicates that GDF-15 is not much guiding in the prediction and monitoring of OSAS severity.

Anahtar Kelimeler

Sleep apnea syndrome, OSAS, GDF-15, REM, NREM, Apnea

Kaynakça

• 1. Gaudette E, Kimoff R. Pathophysiology of OSA. European Respiratory Monograph, 2010;50:31.
• 2. Parish JM. Genetic and immunologic aspects of sleep and sleep disorders. Chest, 2013;143(5):1489-1499.
• 3. Eckert DJ, Malhotra A. Pathophysiology of adult obstructive sleep apnea. Proceedings of the American thoracic society, 2008;5(2):144-153.
• 4. Dewan NA, Nieto FJ, Somers VK. Intermittent hypoxemia and OSA: implications for comorbidities. Chest, 2015;147(1):266-274.
• 5. Badran M, Ayas N, Laher I. Cardiovascular complications of sleep apnea: role of oxidative stress. Oxidative Medicine and Cellular Longevity, 2014, Article ID 985258, 10.
• 6. Jelic S, Le Jemtel TH. Inflammation, oxidative stress, and the vascular endothelium in obstructive sleep apnea. Trends in cardiovascular medicine, 2008;18(7):253-260.
• 7. Tamisier R. Nights of intermittent hypoxia elevate daytime blood pressure and sympathetic activity in healthy humans. European respiratory journal, 2011;37(1):119-128.
• 8. Framnes NS, Arble MD. The Bidirectional Relationship Between Obstructive Sleep Apnea and Metabolic Disease. Front. Endocrinol, 2018;9:440.
• 9. Kim M, Cha I S, Choi J K.et al. Prognostic Value of Serum Growth Differentiation Factor-15 in Patients with Chronic Obstructive Pulmonary Disease Exacerbation. Tuberc Respir Dis, 2014;77:243-250.
• 10. Sari K, Ede H, Gencer KZ. The Correlation of Serum Growth Differentiation Factor-15 Level in Patients with Obstructive Sleep Apnea. BioMed Research International, 2015, Article ID 807683, 5.
• 11. Berry RB. The AASM manual for the scoring of sleep and associated events. Rules, Terminology and Technical Specifications, Darien, Illinois, American Academy of Sleep Medicine, 2012. 176.
• 12. Shimano M, Ouchi N, Walsh K. Cardiokines: recent progress in elucidating the cardiac secretome. Circulation, 2012;126:327-332.
• 13. Lankeit M, Kempf T, Dellas C, Cuny M, Tapken H, Peter T, et al. Growth differentiation factor-15 for prognostic assessment of patients with acute pulmonary embolism. Am J Respir Crit Care Med, 2008;177:1018-1025.
• 14. Nickel N, Kempf T, Tapken H, Tongers J, Laenger F, Lehmann U, et al. Growth differentiation factor-15 in idiopathic pulmonary arterial hypertension. Am J Respir Crit Care Med, 2008;178:534-541.
• 15. Levent Öztürk. Bölüm 1. Uykuda Solunum Fizyolojisi. Oya İtil, Oğuz Köktürk, Sadık Ardıç, Çağlar Çuhdaroğlu, Hikmet Fırat: Uykuda Solunum Bozuklukları.1. Baskı. Ankara, 2015:26-32.
• 16. Rechtschaffen A, Siegel J: Chapter47. Sleep and Dreaming. In Kandel, ER, Schwartz JH, Jessell TM eds.: Principles of Neural Science. 4. Baskı. New York: McGraw Hill; 2000:936-947.
• 17. Chokroverty S: Chapter 7. Physiologic Changes in Sleep. In Chokroverty S ed.: Sleep Disorders Medicine: Basic Science, Technical Considerations and Clinical Aspects. 3. Baskı. Philadelphia: Saunders; 2009:80-104.