The effects of first trimester cholesterol levels on pregnancy outcomes

Year 2022, Volume: 39 Issue: 1, 125 - 127, 01.01.2022

Zehra Yılmaz , Canan Soyer Çalışkan , Nur Dokuzeylül Güngör , Merve Yılmaz , Samettin Çelik , Sebahattin Çelik

Abstract

The purpose of this study was to determine whether changes in lipid profile in pregnant women might have any effect on the perinatal outcomes. This retrospective study was conducted between January 2020 and December 2020 by evaluating data drawn from the hospital database. The total serum cholesterol(C), HDL-C, LDL-C, VLDL-C and triglycerides levels were measured in 587 women during the first trimester of pregnancy and confounding factors were analyzed. The mean age was 27 years. The mean gravida and parity were 2 and 1 respectively. The mean birth weight of newborn was 3280 g. The mean Apgar score was 9 at 0 and 5 minutes respectively. The vaginal delivery rate was 68.3% whereas caeserian delivery rate was 31.7%. Neonatal intensive care unit (NICU) was needed in 0.5% of newborns. There was no significant statistical difference between the rates of caeserian section and vaginal delivery in patients with respect to lipid profile levels. The total serum cholesterol(C), triglycerides, LDL-C and VLDL-C levels were significantly higher in mothers of babies hospitalized in NICU.HDL-C level was similar between two groups. Adequate lipid levels in the first trimester of pregnancy are crucial for the health of pregnant women and newborn. High levels of lipids can increase NICU need but not effect way of delivery.

Keywords

HDL-C, LDL-C, pregnancy, VLDL-C, Triglyceride, Total cholesterol

Supporting Institution

none

Project Number

-

Thanks

none

References

• 1- Bartels Ä , Egan N, Broadhurst DI, Khashan AS, Joyce C, Stapleton M et al.Maternal serum cholesterol levels are elevated from the 1st trimester of pregnancy: A cross-sectional study. J. Obstet. Gynaecol. 2012;32(8):747–52.
• 2-Ghio A., Bertolotto A., Resi V., Volpe L. ,Di Cianni G. Triglyceride metabolism in pregnancy. Adv. Clin. Chem.2012; 55: 133–153.
• 3- Herrera, E.,Ortega-Senovilla, H. Lipid metabolism during pregnancy and its implications for fetal growth. Curr. Pharm. Biotechnol.2014: 15(1), 24–31.
• 4- Vrijkotte TGM,Krukziener N,Hutten BA,Vollebregt KC,Eijsden M,Twickler MB,Maternal lipid profile during early pregnancy and pregnancy complications and outcomes: The ABCD study. J. Clin. Endocrinol. Metab.2012: 97(11), 3917-25 .
• 5-Chen Q, Chen H, Xi F, Sagnelli M, Zhao B, Chen Y, et al.Sci Rep. Association between maternal blood lipids levels during pregnancy and risk of small-for-gestational-age infants. 2020 Nov 16;10(1):19865.
• 6- Salameh WA, Mastrogiannis DS.Maternal hyperlipidemia in pregnancy. Clin Obstet Gynecol 1994;37(1):66–77.
• 7- Desoye G, Schweditsch MO, Pfeiffer KP, Zechner R, Kostner GM.Correlation of hormones with lipid and lipoprotein levels during normal pregnancy and postpartum. J Clin Endocrinol Metab.1987; 64:704–12.
• 8- Franz H, Wendler D. A controlled study of maternal serum concentrations of lipoproteins in pregnancy-induced hypertension. Arch Gynecol Obstet 1992; 252(2): 81-86.
• 9-Montelongo A, Lasuncion MA, Pallardo LF, Herrera E. Longitudinal study of plasma lipoproteins and hormones during pregnancy in normal and diabetic women. Diabetes 1992; 41(12): 1651-59.
• 10-Zheng W, Huang W, Zhang L,Tian Z,Wang T.,Zhang T., et al. Changes in serum lipid levels during pregnancy and association with neonatal outcomes: a large cohort study. Reprod Sci. 2018;25(9):1406-12.
• 11-.Emet T, Ustüner I, Güvendağ Güven S, Balık G, Ural ÜM, Bayoğlu Tekin Y,et al. Plasma lipids and lipoproteins during pregnancy and related pregnancy outcomes Arch Gynecol Obstet.2013 ;288(1):49-55.
• 12- Zheng W, Zhang L, Tian Z, Zhang L, Liang X, Li G. Establishing reference ranges of serum lipid level during pregnancy and evaluating its association with perinatal outcomes: A cohort study. Int J Gynaecol Obstet.2021 doi: 10.1002/ijgo.13636. Online ahead of print.
• 13-.Prediction of neonates' macrosomia with maternal lipid profile of healthy mothers Mossayebi E, Arab Z, Rahmaniyan M, Almassinokiani F, Kabir A.Pediatr Neonatol. 2014;55(1):28-34.