Neuroprotective effect of carvacrol in an experimental cerebral ischemia and reperfusion rat model

Yıl 2022, Cilt: 39 Sayı: 2, 454 - 458, 18.03.2022

Mustafa Başaran Mustafa Namık Öztanır Oisman Çiftçi Neşe Başak Türkmen Yener Akyuva Arif Önder

Öz

Cerebral ischemia is the third leading cause of death after cancer and cardiovascular diseases in the developed societies. In recent years, one of the most important treatment protocols applied in stroke treatment is the neuroprotective treatment, which limits cell damage occurring within the area of infarct. The carvacrol, which has an anti-inflammatory effect, shows neuroprotective activity in cerebral tissue with an infarct, but this effect is not sufficiently elucidated at the molecular level.The aim of our study was to investigate the effects of carvacrol on plasma TBARS, GSH, SOD, CAT, GPx, IL-1 BETA, IL-4 and TNF-ALPHA levels in the cerebral tissue, by creating global ischemia in the laboratory conditions.

Anahtar Kelimeler

Experimental, Cerebral Ischemia, carvacrol, Ischemia Reperfusion

Kaynakça

• Referans1. Civelek E, Akyuva Y, Kaplan N, Diren F, Boyali O, Kabatas S. Challenges in the Clinical and Radiological Differential Diagnosis of Cerebrovascular Events and Malignant Primary Brain Tumors: Reports from a Retrospective Case Series. Turk Neurosurg. 2020; 30(4): 604-613. doi: 10.5137/1019-5149.JTN.30371-20.2. PMID: 32530485.
• Referans2. Oztanir MN, Ciftci O, Cetin A, Durak MA, Basak N, Akyuva Y. The beneficial effects of 18β-glycyrrhetinic acid following oxidative and neuronal damage in brain tissue caused by global cerebral ischemia/reperfusion in a C57BL/J6 mouse model. Neurol Sci. 2014 Aug; 35(8): 1221-1228. doi: 10.1007/s10072-014-1685-9. Epub 2014 Feb 20. PMID: 24554419.
• Referans3. Wang P, Luo Q, Qiao H, Ding H, Cao Y, Yu J, Liu R, Zhang Q, Zhu H, Qu L. The Neuroprotective Effects of Carvacrol on Ethanol-Induced Hippocampal Neurons Impairment via the Antioxidative and Antiapoptotic Pathways. Oxid Med Cell Longev. 2017; 2017: 4079425. doi: 10.1155/2017/4079425. Epub 2017 Jan 16. PMID: 28191274; PMCID: PMC5278232.
• Referans4. Zare Mehrjerdi F, Niknazar S, Yadegari M, Akbari FA, Pirmoradi Z, Khaksari M. Carvacrol reduces hippocampal cell death and improves learning and memory deficits following lead-induced neurotoxicity via antioxidant activity. Naunyn Schmiedebergs Arch Pharmacol. 2020 Jul; 393(7): 1229-1237. doi: 10.1007/s00210-020-01866-6. Epub 2020 Apr 17. PMID: 32303785.
• Referans5. Kachur K, Suntres Z. The antibacterial properties of phenolic isomers, carvacrol and thymol. Crit Rev Food Sci Nutr. 2020; 60(18): 3042-3053. doi: 10.1080/10408398.2019.1675585. Epub 2019 Oct 16. PMID: 31617738.
• Referans6. Soares ROS, Losada DM, Jordani MC, Évora P, Castro-E-Silva O. Ischemia/Reperfusion Injury Revisited: An Overview of the Latest Pharmacological Strategies. Int J Mol Sci. 2019 Oct 11; 20(20): 5034. doi: 10.3390/ijms20205034. PMID: 31614478; PMCID: PMC6834141.
• Referans7. Wu L, Xiong X, Wu X, Ye Y, Jian Z, Zhi Z, Gu L. Targeting Oxidative Stress and Inflammation to Prevent Ischemia-Reperfusion Injury. Front Mol Neurosci. 2020 Mar 5; 13: 28. doi: 10.3389/fnmol.2020.00028. PMID: 32194375; PMCID: PMC7066113.
• Referans8. Vishwakarma VK, Upadhyay PK, Gupta JK, Yadav HN. Pathophysiologic role of ischemia reperfusion injury: A review. J Indian Col of Cardiology. 2017; 7(3): 97-104. doi.org/10.1016/j.jicc.2017.06.017.
• Referans9. Akyuva Y, Onal C, Parlakpinar H, Gul M, Cigremis Y, Ates T, Kablan Y. The effect of apocynin on motor and cognitive functions in experimental Alzheimer’s disease. Periodicum biologorum. 2018; 120(1): 23-32. doi.org/10.18054/pb.v120i1.5975
• Referans10. Salehi C, Seiiedy M, Soraya H, Fazli F, Ghasemnejad-Berenji M. Pretreatment with bisoprolol and vitamin E alone or in combination provides neuroprotection against cerebral ischemia/reperfusion injury in rats. Naunyn Schmiedebergs Arch Pharmacol. 2021 Apr; 394(4): 685-695. doi: 10.1007/s00210-020-02007-9. Epub 2020 Oct 27. PMID: 33106920.
• Referans11. Tian F, Liu R, Fan C, Sun Y, Huang X, Nie Z, Zhao X, Pu X. Effects of Thymoquinone on Small-Molecule Metabolites in a Rat Model of Cerebral Ischemia Reperfusion Injury Assessed using MALDI-MSI. Metabolites. 2020 Jan 7; 10(1): 27. doi: 10.3390/metabo10010027. PMID: 31936061; PMCID: PMC7023359.
• Referans12. Akyuva Y, Nazıroğlu M, Yıldızhan K. Selenium prevents interferon-gamma induced activation of TRPM2 channel and inhibits inflammation, mitochondrial oxidative stress, and apoptosis in microglia. Metab Brain Dis. 2021 Feb; 36(2): 285-298. doi: 10.1007/s11011-020-00624-0. Epub 2020 Oct 12. PMID: 33044639.
• Referans13. Suo L, Kang K, Wang X, Cao Y, Zhao H, Sun X, Tong L, Zhang F. Carvacrol alleviates ischemia reperfusion injury by regulating the PI3K-Akt pathway in rats. PLoS One. 2014 Aug 1; 9(8): e104043. doi: 10.1371/journal.pone.0104043. PMID: 25083879; PMCID: PMC4118998.
• Referans14. Jiang ZS, Pu ZC, Hao ZH. Carvacrol protects against spinal cord injury in rats via suppressing oxidative stress and the endothelial nitric oxide synthase pathway. Mol Med Rep. 2015 Oct; 12(4): 5349-54. doi: 10.3892/mmr.2015.4045. Epub 2015 Jul 6. PMID: 26151839.
• Referans15. Shoorei H, Khaki A, Khaki AA, Hemmati AA, Moghimian M, Shokoohi M. The ameliorative effect of carvacrol on oxidative stress and germ cell apoptosis in testicular tissue of adult diabetic rats. Biomed Pharmacother. 2019 Mar; 111: 568-578. doi: 10.1016/j.biopha.2018.12.054. Epub 2018 Dec 29. PMID: 30597310.
• Referans16. Yu H, Zhang ZL, Chen J, Pei A, Hua F, Qian X, He J, Liu CF, Xu X. Carvacrol, a food-additive, provides neuroprotection on focal cerebral ischemia/reperfusion injury in mice. PLoS One. 2012; 7(3): e33584. doi: 10.1371/journal.pone.0033584. Epub 2012 Mar 16. PMID: 22438954; PMCID: PMC3306416.
• Referans17. Peters M, Trembovler V, Alexandrovich A, Parnas M, Birnbaumer L, Minke B, Shohami E. Carvacrol together with TRPC1 elimination improve functional recovery after traumatic brain injury in mice. J Neurotrauma. 2012 Dec 10; 29(18): 2831-4. doi: 10.1089/neu.2012.2575. Epub 2012 Nov 16. PMID: 22994850; PMCID: PMC3521132.
• Referans18. Li WT, Zhang SY, Zhou YF, Zhang BF, Liang ZQ, Liu YH, Wei Y, Li CK, Meng XJ, Xia M, Dan Y, Song JN. Carvacrol attenuates traumatic neuronal injury through store-operated Ca(2+) entry-independent regulation of intracellular Ca(2+) homeostasis. Neurochem Int. 2015 Nov; 90: 107-13. doi: 10.1016/j.neuint.2015.07.020. Epub 2015 Jul 26. PMID: 26220904.
• Referans19. Guan X, Li X, Yang X, Yan J, Shi P, Ba L, Cao Y, Wang P. The neuroprotective effects of carvacrol on ischemia/reperfusion-induced hippocampal neuronal impairment by ferroptosis mitigation. Life Sci. 2019 Oct 15; 235: 116795. doi: 10.1016/j.lfs.2019.116795. Epub 2019 Aug 27. PMID: 31470002.
• Referans20. Hong DK, Choi BY, Kho AR, Lee SH, Jeong JH, Kang BS, Kang DH, Park KH, Suh SW. Carvacrol Attenuates Hippocampal Neuronal Death after Global Cerebral Ischemia via Inhibition of Transient Receptor Potential Melastatin 7. Cells. 2018 Nov 26; 7(12): 231. doi: 10.3390/cells7120231. PMID: 30486272; PMCID: PMC6315386.