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The relationship between the degree of prolapse and bone mineral density in postmenopausal women with pelvic organ prolapse

Yıl 2022, Cilt: 39 Sayı: 3, 660 - 663, 30.08.2022

Öz

Objective: This study aimed to investigate the relationship between the degree of prolapse and bone mineral density (BMD) in postmenopausal women with pelvic organ prolapse (POP).
Materials and Methods: This retrospective study including 40 postmenopausal women who were operated for POP was conducted in University of Health Sciences, Ankara City Hospital, Turkey. While patients who had grade <3 vaginal cuff prolapse were accepted as low grade prolapse, patients with grade ≥ 3 vaginal cuff prolapse were accepted as high grade prolapse. Patients' demographic characteristics, obstetric and gynecological history, laboratory findings and dual-energy X-ray absorptiometry results were recorded as study parameters.
Results: The mean age of the early stage and advanced stage patients was 55.2 ± 6.5 years vs 57.8 ± 5.7 years respectively (p = 0.222). Also, there were no significant differences between the groups in terms of body mass index, gravida, parity, follicle stimulating hormone levels. BMD of the femur neck and lumbar spine and T score of the femur neck were significantly higher in the low grade prolapse group than in the high grade prolapse group. In addition, estradiol levels of the high grade prolapse group was lower than the low grade prolapse group.
Conclusion: BMD and T score of the femur neck and BMD of the lumbar spine were found to be significantly lower in the high grade prolapse group, suggesting that, there may be an association between the severity of POP and the risk of osteoporosis in postmenopausal women.

Kaynakça

  • Jelovsek JE, Maher C, Barber MD. Pelvic organ prolapse. The Lancet. 2007;369(9566):1027-1038.
  • on Osteoporosis NCDP, Prevention D. Osteoporosis prevention, diagnosis, and therapy. JAMA. 2001;285(6):785-795.
  • Swift S, Pound T, Dias J. Case–control study of etiologic factors in the development of severe pelvic organ prolapse. International Urogynecology Journal. 2001;12(3):187-192.
  • Vergeldt TF, Weemhoff M, IntHout J, Kluivers KB. Risk factors for pelvic organ prolapse and its recurrence: a systematic review. International urogynecology journal. 2015;26(11):1559-1573.
  • Sözen T, Özışık L, Başaran NÇ. An overview and management of osteoporosis. European journal of rheumatology. 2017;4(1):46.
  • Pouresmaeili F, Kamalidehghan B, Kamarehei M, Goh YM. A comprehensive overview on osteoporosis and its risk factors. Therapeutics and clinical risk management. 2018;14:2029.
  • Lang J, Zhu L, Sun Z, Chen J. Estrogen levels and estrogen receptors in patients with stress urinary incontinence and pelvic organ prolapse. International Journal of Gynecology & Obstetrics. 2003;80(1):35-39.
  • Lee S, Cho H, Kim M, You Y, Kim S, Hwang Y, et al. Association between pelvic organ prolapse and bone mineral density in postmenopausal women. Journal of Obstetrics and Gynaecology. 2015;35(5):476-480.
  • Pal L. Pelvic organ prolapse and relationship with skeletal integrity. Women’s Health. 2009;5(3):325-333.
  • Pal L, Hailpern SM, Santoro NF, Freeman R, Barad D, Kipersztok S, et al. Increased Incident Hip Fractures in Postmenopausal Women with Moderate-to-Severe Pelvic Organ Prolapse. Menopause (New York, NY). 2011;18(9):967.
  • Ko Y-R, Lee S-R, Kim S-H, Chae H-D. Pelvic Organ Prolapse Is Associated with Osteoporosis in Korean Women: Analysis of the Health Insurance Review and Assessment Service National Patient Sample. Journal of Clinical Medicine. 2021;10(16):3751.
  • Baden WF, Walker T. Surgical repair of vaginal defects: Lippincott Williams & Wilkins; 1992.
  • Kanis JA, Melton III LJ, Christiansen C, Johnston CC, Khaltaev N. The diagnosis of osteoporosis. Journal of bone and mineral research. 1994;9(8):1137-1141.
  • Pal L, Hailpern SM, Santoro NF, Freeman R, Barad D, Kipersztok S, et al. Association of pelvic organ prolapse and fractures in postmenopausal women: analysis of baseline data from the Women's Health Initiative Estrogen Plus Progestin trial. Menopause. 2008;15(1):59-66.
  • Carley ME, Schaffer J. Urinary incontinence and pelvic organ prolapse in women with Marfan or Ehlers-Danlos syndrome. American journal of obstetrics and gynecology. 2000;182(5):1021-1023.
  • Yoldemir T, Erenus M. Should we consider assessment of bone mineral density earlier in postmenopausal women with pelvic organ prolapse? Climacteric. 2011;14(3):392-397.
  • Nachtigall MJ, Nazem TG, Nachtigall RH, Goldstein SR. Osteoporosis risk factors and early life-style modifications to decrease disease burden in women. Clinical obstetrics and gynecology. 2013;56(4):650-653.
  • Kline J, Tang A, Levin B. Smoking, alcohol and caffeine in relation to two hormonal indicators of ovarian age during the reproductive years. Maturitas. 2016;92:115-122.
Yıl 2022, Cilt: 39 Sayı: 3, 660 - 663, 30.08.2022

Öz

Kaynakça

  • Jelovsek JE, Maher C, Barber MD. Pelvic organ prolapse. The Lancet. 2007;369(9566):1027-1038.
  • on Osteoporosis NCDP, Prevention D. Osteoporosis prevention, diagnosis, and therapy. JAMA. 2001;285(6):785-795.
  • Swift S, Pound T, Dias J. Case–control study of etiologic factors in the development of severe pelvic organ prolapse. International Urogynecology Journal. 2001;12(3):187-192.
  • Vergeldt TF, Weemhoff M, IntHout J, Kluivers KB. Risk factors for pelvic organ prolapse and its recurrence: a systematic review. International urogynecology journal. 2015;26(11):1559-1573.
  • Sözen T, Özışık L, Başaran NÇ. An overview and management of osteoporosis. European journal of rheumatology. 2017;4(1):46.
  • Pouresmaeili F, Kamalidehghan B, Kamarehei M, Goh YM. A comprehensive overview on osteoporosis and its risk factors. Therapeutics and clinical risk management. 2018;14:2029.
  • Lang J, Zhu L, Sun Z, Chen J. Estrogen levels and estrogen receptors in patients with stress urinary incontinence and pelvic organ prolapse. International Journal of Gynecology & Obstetrics. 2003;80(1):35-39.
  • Lee S, Cho H, Kim M, You Y, Kim S, Hwang Y, et al. Association between pelvic organ prolapse and bone mineral density in postmenopausal women. Journal of Obstetrics and Gynaecology. 2015;35(5):476-480.
  • Pal L. Pelvic organ prolapse and relationship with skeletal integrity. Women’s Health. 2009;5(3):325-333.
  • Pal L, Hailpern SM, Santoro NF, Freeman R, Barad D, Kipersztok S, et al. Increased Incident Hip Fractures in Postmenopausal Women with Moderate-to-Severe Pelvic Organ Prolapse. Menopause (New York, NY). 2011;18(9):967.
  • Ko Y-R, Lee S-R, Kim S-H, Chae H-D. Pelvic Organ Prolapse Is Associated with Osteoporosis in Korean Women: Analysis of the Health Insurance Review and Assessment Service National Patient Sample. Journal of Clinical Medicine. 2021;10(16):3751.
  • Baden WF, Walker T. Surgical repair of vaginal defects: Lippincott Williams & Wilkins; 1992.
  • Kanis JA, Melton III LJ, Christiansen C, Johnston CC, Khaltaev N. The diagnosis of osteoporosis. Journal of bone and mineral research. 1994;9(8):1137-1141.
  • Pal L, Hailpern SM, Santoro NF, Freeman R, Barad D, Kipersztok S, et al. Association of pelvic organ prolapse and fractures in postmenopausal women: analysis of baseline data from the Women's Health Initiative Estrogen Plus Progestin trial. Menopause. 2008;15(1):59-66.
  • Carley ME, Schaffer J. Urinary incontinence and pelvic organ prolapse in women with Marfan or Ehlers-Danlos syndrome. American journal of obstetrics and gynecology. 2000;182(5):1021-1023.
  • Yoldemir T, Erenus M. Should we consider assessment of bone mineral density earlier in postmenopausal women with pelvic organ prolapse? Climacteric. 2011;14(3):392-397.
  • Nachtigall MJ, Nazem TG, Nachtigall RH, Goldstein SR. Osteoporosis risk factors and early life-style modifications to decrease disease burden in women. Clinical obstetrics and gynecology. 2013;56(4):650-653.
  • Kline J, Tang A, Levin B. Smoking, alcohol and caffeine in relation to two hormonal indicators of ovarian age during the reproductive years. Maturitas. 2016;92:115-122.
Toplam 18 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Clinical Research
Yazarlar

Duygu Tuğrul Ersak 0000-0001-8591-8395

Burak Ersak 0000-0003-3301-062X

Mahmut Kuntay Kokanalı 0000-0002-0760-446X

Erken Görünüm Tarihi 30 Ağustos 2022
Yayımlanma Tarihi 30 Ağustos 2022
Gönderilme Tarihi 13 Aralık 2021
Kabul Tarihi 23 Mart 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 39 Sayı: 3

Kaynak Göster

APA Tuğrul Ersak, D., Ersak, B., & Kokanalı, M. K. (2022). The relationship between the degree of prolapse and bone mineral density in postmenopausal women with pelvic organ prolapse. Journal of Experimental and Clinical Medicine, 39(3), 660-663.
AMA Tuğrul Ersak D, Ersak B, Kokanalı MK. The relationship between the degree of prolapse and bone mineral density in postmenopausal women with pelvic organ prolapse. J. Exp. Clin. Med. Ağustos 2022;39(3):660-663.
Chicago Tuğrul Ersak, Duygu, Burak Ersak, ve Mahmut Kuntay Kokanalı. “The Relationship Between the Degree of Prolapse and Bone Mineral Density in Postmenopausal Women With Pelvic Organ Prolapse”. Journal of Experimental and Clinical Medicine 39, sy. 3 (Ağustos 2022): 660-63.
EndNote Tuğrul Ersak D, Ersak B, Kokanalı MK (01 Ağustos 2022) The relationship between the degree of prolapse and bone mineral density in postmenopausal women with pelvic organ prolapse. Journal of Experimental and Clinical Medicine 39 3 660–663.
IEEE D. Tuğrul Ersak, B. Ersak, ve M. K. Kokanalı, “The relationship between the degree of prolapse and bone mineral density in postmenopausal women with pelvic organ prolapse”, J. Exp. Clin. Med., c. 39, sy. 3, ss. 660–663, 2022.
ISNAD Tuğrul Ersak, Duygu vd. “The Relationship Between the Degree of Prolapse and Bone Mineral Density in Postmenopausal Women With Pelvic Organ Prolapse”. Journal of Experimental and Clinical Medicine 39/3 (Ağustos 2022), 660-663.
JAMA Tuğrul Ersak D, Ersak B, Kokanalı MK. The relationship between the degree of prolapse and bone mineral density in postmenopausal women with pelvic organ prolapse. J. Exp. Clin. Med. 2022;39:660–663.
MLA Tuğrul Ersak, Duygu vd. “The Relationship Between the Degree of Prolapse and Bone Mineral Density in Postmenopausal Women With Pelvic Organ Prolapse”. Journal of Experimental and Clinical Medicine, c. 39, sy. 3, 2022, ss. 660-3.
Vancouver Tuğrul Ersak D, Ersak B, Kokanalı MK. The relationship between the degree of prolapse and bone mineral density in postmenopausal women with pelvic organ prolapse. J. Exp. Clin. Med. 2022;39(3):660-3.