Spexin (SPX ) s a recently discovered endogenous peptide consisting of 14 amino acids. It was found that SPX, kisspeptin (KISS), and galanin (GAL) peptides belong to the same gene family and is also endogenous ligand of GAL2 and GAL3 receptors. The amino acid sequence of the SPX peptide is relatively conserved in vertebrates and invertebrates. The mRNA and protein of SPX are highly expressed both in peripheral organs and the peripheral/central nervous system of mammals, birds, and fishes. Many biological roles of SPX were found in non-mammal/mammals, including food intake, energy metabolism, reproduction, nociception, gastrointestinal motility, stress, and endocrine functions. This review collectively mentions the peptide structure of SPX, its receptors and distribution in tissues, and the biological activities of SPX on various organs.
galanin-2 receptor galanin-3 receptor Neuropeptide NPQ spexin
Birincil Dil | İngilizce |
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Konular | Sağlık Kurumları Yönetimi |
Bölüm | Review Articles |
Yazarlar | |
Erken Görünüm Tarihi | 30 Ağustos 2022 |
Yayımlanma Tarihi | 30 Ağustos 2022 |
Gönderilme Tarihi | 26 Mayıs 2022 |
Kabul Tarihi | 16 Haziran 2022 |
Yayımlandığı Sayı | Yıl 2022 Cilt: 39 Sayı: 3 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.