Miscarriage in a patient with Glanzmann Thrombasthenia and low ovarian reserve: a case report

Yıl 2022, Cilt: 39 Sayı: 4, 1300 - 1302, 29.10.2022

Işılsu Ezgi Uluışık Mert Sonkaya Nur Dokuzeylül Güngör

Öz

Glanzmann thrombasthenia (GT) is an autosomal recessive hemorrhagic disorder mostly complicated by mucocutaneous bleeding. The severity of this bleeding disorder varies from mild bruising to frequent severe bleeding. Prepartum, peripartum and postpartum bleeding risks are increased in these patients. In addition to the hemorrhagic complications which endanger maternal and fetal wellbeing, the risk of miscarriage is increased due to maternal antibodies to the platelets which are also found on conceptus-derived trophoblast (placental) cells. This case report is about a patient with GT, complicated by infertility, low ovarian reserve, HPV positivity and bilateral dermoid cyst, who had a miscarriage in 7+1 week.

Anahtar Kelimeler

in vitro fertilization, assisted reproductive technics, glanzmann thrombasthenia, miscarriage

Kaynakça

• 1. Nurden AT. Glanzmann thrombasthenia. Orphanet J Rare Dis. 2006 ;1(1):10.
• 2. Poon MC, Di Minno G, d’Oiron R, Zotz R. New Insights Into the Treatment of Glanzmann Thrombasthenia. Transfusion Medicine Reviews. 2016 ;30(2):92–9.
• 3. Clemetson KJ. Platelets and Primary Haemostasis. Thrombosis Research. 2012 ;129(3):220–4.
• 4. Wijemanne A, Watt-Coote I, Austin S. Glanzmann thrombasthenia in pregnancy: Optimising maternal and fetal outcomes. Obstet Med. 2016 ;9(4):169–70.
• 5. Botero JP, Lee K, Branchford BR, Bray PF, Freson K, Lambert MP, et al. Glanzmann thrombasthenia: genetic basis and clinical correlates. Haematologica. 2020 ;105(4):888–94.
• 6. Nurden AT. Acquired Antibodies to α IIbβ3 in Glanzmann Thrombasthenia: From Transfusion and Pregnancy to Bone Marrow Transplants and Beyond. Transfusion Medicine Reviews. 2018 ;32(3):155–64.
• 7. Yougbaré I, Tai WS, Zdravic D, Oswald BE, Lang S, Zhu G, et al. Activated NK cells cause placental dysfunction and miscarriages in fetal alloimmune thrombocytopenia. Nat Commun. 2017 ;8(1):224.
• 8. Nurden A, Pillois X, Fiore M, Heilig R, Nurden P. Glanzmann Thrombasthenia-Like Syndromes Associated with Macrothrombocytopenias and Mutations in the Genes Encoding the αIIbβ3 Integrin. Semin Thromb Hemost. 2011 ;37(06):698–706.
• 9. Busnelli A, Somigliana E, Cirillo F, Levi-Setti PE. Is diminished ovarian reserve a risk factor for miscarriage? Results of a systematic review and meta-analysis. Human Reproduction Update. 2021 ;27(6):973–88.
• 10. Lyttle Schumacher BM, Jukic AMZ, Steiner AZ. Antimüllerian hormone as a risk factor for miscarriage in naturally conceived pregnancies. Fertility and Sterility. 2018 ;109(6):1065-1071.e1.