Convalescent Plasma Transfusion In Severe Covid-19 Patients Admitted To Intensive Care Unit: A Single Center Study

Year 2023, Volume: 40 Issue: 2, 258 - 263, 19.07.2023

Cokorda Agung Wahyu Purnamasidhi , Ida Bagus Yorky Brahmantya , Ni Made Dewi Dian Sukmawati , Anak Agung Ayu Yuli Gayatri , I Made Susila Utama , I Ketut Agus Somia , I Gusti Ngurah Mahaalit Aribawa , Ketut Tuti Parwati Merati

Abstract

Initial difficult times of novel coronavirus disease 2019 (COVID-19) had clinicians actively seeking appropriate treatment. Convalescent plasma (CP) has been studied for treatment of past coronavirus pandemics and was successful with promising efficacy and safety. This study aims to measure the efficacy of convalescent plasma transfusion in severe COVID-19 patients, determined by alleviation of symptoms, improvement in radiologic findings, and laboratory parameters. Cross-sectional study conducted involving 23 severe COVID-19 patients admitted to Udayana University Hospital intensive care unit in 2020. Patients received a minimum 200 mL CP transfusion, dexamethasone, and remdesivir. Data were retrieved from patient’s medical records. Patients mean age was 54.04 years. Mean time from onset of illness to transfusion and length of stay were 11.09 and 16.70 days respectively. No adverse effects were observed during treatment. Twelve patients (52.2%) showed alleviation of symptoms and recovered, with 15 days median time from transfusion to recovery. Post-transfusion chest x-ray examination showed varying degrees of absorption of lung lesions in 10 patients (43.5%) and was associated with the patient’s outcome (p = 0.001). Significant changes in c-reactive protein (p = 0.000) and procalcitonin level (p = 0.024) was found as compared to pretransfusion. Despite these findings, almost half the patients (47.8%) did not receive benefits from CP transfusion and dead. CP transfusion has shown remarkable improvement in radiologic, inflammatory, and prognostic parameters but was unable to improve patient clinical outcomes and mortality rate.

Keywords

convalescent plasma therapy, COVID-19, critical care, outcome

Supporting Institution

The authors declare this study has not received support from any Institution.

Thanks

The authors wish to thank Professor Dewa Putu Gde Purwa Samatra as the former chief director and Professor I Dewa Made Sukrama as the current chief director of Udayana University Hospital, Professor I Ketut Suyasa as the former Dean, and Doctor Komang Januartha Putra Pinatih as the current Dean of Udayana University Faculty of Medicine, for the permission to conduct this study.

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