Primary malignant bone tumors of hematopoietic origin: A single-center retrospective study

Year 2023, Volume: 40 Issue: 3, 619 - 621, 30.09.2023

İsmail Büyükceran , Şafak Aydın Şimşek , Oğuzhan Muslu , Tolgahan Cengiz , Hüseyin Sina Coşkun , Nevzat Dabak

Abstract

Tumors of hematopoietic origin are rare tumors that can be confused with benign and malignant tumors of the bone with their clinical and morphological features. Plasma cell myeloma, solitary plasmacytoma, Non-Hodgkin Lymphoma, acute lymphoblastic leukemia/lymphoma, and Langerhans cell histiocytosis are hematological neoplasms that mainly involve the bone. Plasma cell myeloma is the most common primary malignant bone neoplasm, and diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma arising in bone. In this case report, we will retrospectively investigate the diagnosis and treatment management and postoperative clinical outcomes of patients diagnosed with tumors of hematopoietic origin, evaluated by the Bone and Soft Tissue Tumor Council between 2005 and 2021, and emphasize the importance of the approach to these tumors.

Keywords

hematopoetic myelodysplasia, multiple myeloma, bone neoplasms, leukemia

References

• 1. Kim SH, Smith SE, Mulligan ME. Hematopoietic tumors and metastases involving bone. Radiologic Clinics. 2011;49(6):1163-83.
• 2. Cleven AHG, Hogendoorn PCW. Hematopoietic Tumors Primarily Presenting in Bone. Surgical Pathology Clinics. 2017;10(3):675-91. doi https://doi.org/10.1016/j.path.2017.04.011.
• 3. Zajączkowska R, Kocot-Kępska M, Leppert W, Wordliczek J. Bone Pain in Cancer Patients: Mechanisms and Current Treatment. International journal of molecular sciences. 2019;20(23). Epub 2019/12/06. doi: 10.3390/ijms20236047. PubMed PMID: 31801267; PubMed Central PMCID: PMCPMC6928918.
• 4. Röllig C, Knop S, Bornhäuser M. Multiple myeloma. Lancet (London, England). 2015;385(9983):2197-208. Epub 2014/12/30. doi: 10.1016/s0140-6736(14)60493-1. PubMed PMID: 25540889.
• 5. Mendenhall WM, Mendenhall CM, Mendenhall NP. Solitary plasmacytoma of bone and soft tissues. American Journal of otolaryngology. 2003;24(6):395-9. Epub 2003/11/11. doi: 10.1016/s0196-0709(03)00092-9. PubMed PMID: 14608572.
• 6. Hernandez E, Rowan R, Randall M. A Case of Extranodal Metastasis of Primary Bone Lymphoma in the Lower Extremity. Journal of the American Podiatric Medical Association. 2018;108(1):52-7. Epub 2018/03/17. doi: 10.7547/15-115. PubMed PMID: 29547041.
• 7. Lin P, Huang RF, Xie RT, Zhang YL, Zhuang WH, Zhang XY. [The Types and Laboratory Characteristics of Non-Hodgkin Lymphoma with Bone Marrow Invasion as the First Manifestation]. Zhongguo shi yan xue ye xue za zhi. 2021;29(4):1148-55. Epub 2021/08/08. doi: 10.19746/j.cnki.issn.1009-2137.2021.04.020. PubMed PMID: 34362495.
• 8. Reisi N, Raeissi P, Harati Khalilabad T, Moafi A. Unusual sites of bone involvement in Langerhans cell histiocytosis: a systematic review of the literature. Orphanet J Rare Dis. 2021;16(1):1. Epub 2021/01/04. doi: 10.1186/s13023-020-01625-z. PubMed PMID: 33388073; PubMed Central PMCID: PMCPMC7778820.
• 9. Coleman RE, Croucher PI, Padhani AR, Clézardin P, Chow E, Fallon M, et al. Bone metastases. Nature reviews Disease primers. 2020;6(1):83. Epub 2020/10/17. doi: 10.1038/s41572-020-00216-3. PubMed PMID: 33060614.
• 10. Reich CD. Advances in the treatment of bone metastases. Clinical journal of oncology nursing. 2003;7(6):641- 6. Epub 2004/01/07. doi: 10.1188/03.Cjon.641-646. PubMed PMID: 14705479.
• 11. Piccioli A, Maccauro G, Spinelli MS, Biagini R, Rossi B. Bone metastases of unknown origin: epidemiology and principles of management. Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology. 2015;16(2):81-6. Epub 2015/03/03. doi: 10.1007/s10195-015-0344-0. PubMed PMID: 25726410; PubMed Central PMCID: PMCPMC4441638.