Protective role of Ferulic acid on acrylamide-induced testis toxicity in rats

Year 2023, Volume: 40 Issue: 4, 740 - 747, 03.01.2024

Arzu Gezer , Seda Yakut , Nurcan Kılıç Bargutalp , Berrin Tarakcı Gencer

Abstract

It has become important over the last few years to reduce the detrimental effects of Acrylamide (ACR), which is the carcinogenic substance formed by the exposure of some foods to high temperatures. The present investigation evaluated the defensive effect of ferulic acid (FA) as opposed to toxicity in testis tissue triggered by ACR in male rats. ACR (100 ppm) was administered in drinking water alone or with FA for 30 days orally. This study revealed that treatment with FA could remarkably decrease MDA levels and significantly increase SOD levels in the testicular tissue of the ACR-treated rats. Intaking of FA as a supplement is also supported by increasing FSHR, LHR, and AR sex hormone receptors levels. FA also reduced the harmful effects leading to ACR by decreasing histopathological changes in the testicular tissue. This study demonstrated the probable protective mechanism of FA against testicular toxicity caused by ACR.

Keywords

Acrylamide, Ferulic acid, testis, rat

Supporting Institution

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Project Number

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Thanks

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