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Can the gastrointestinal system alter liver damage caused by COVID-19?

Yıl 2024, Cilt: 41 Sayı: 2, 397 - 406, 19.05.2024

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Our gastrointestinal system, often referred to as our "second brain," is grappling with the devastating effects of COVID-19, a disease that has plagued recent years. Researchers are investigating how bacteria in the intestinal microflora may contribute to or mitigate liver damage caused by COVID-19. Despite the limited number of studies, the fight against liver organ damage by the gastrointestinal system, which is our second brain is important. All original articles published in English until March 01, 2020, were retrieved via a library-assisted literature search from PubMed/MEDLINE, Excerpta Medica Database (EMBASE), and Web of Science. A total of nine articles (2.188 patients) were found eligible for inclusion. Effect size and 95% confidence interval were evaluated in this study. The randomized trials exhibit a noteworthy level of heterogeneity (p<0.05), and upon scrutinizing the funnel plot, there is no discernible indication of publication bias. According to the meta-analysis tree graph, the weights of the studies are significantly to the right of the 2 vertical lines. The confidence interval of each study has significant weights. According to the study findings, the interaction of the intestinal flora and the immune system showed us that there is an area that we need to investigate against the COVID-19 disease. For many years, research has tried to explain how the signaling pathways in the intestinal tract are related to the brain. The study revealed that our digestive system plays a crucial role as an auxiliary component of our brain. Future studies should uncover the main ways of this communication.

Kaynakça

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Yıl 2024, Cilt: 41 Sayı: 2, 397 - 406, 19.05.2024

Öz

Kaynakça

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  • Bathina S. & Das U.N. (2015). Brain-derived neurotrophic factor and its clinical implications. Archives of medical sciences, 10;11(6):1164-78. https://doi.org/ 10.5114/aoms.2015.56342
  • Binder D.K. & Scharfman H.E. (2004). Brain-derived neurotrophic factor. Growth Factors, 22(3):123-31. https://doi.org/ 10.1080/08977190410001723308
  • Rodriguez D.M., Benninghoff A.D., Aardema N.D.J., Phatak S. & Hintze K.J. (2019). Basal Diet Determined Long-Term Composition of the Gut Microbiome and Mouse Phenotype to a Greater Extent than Fecal Microbiome Transfer from Lean or Obese Human Donors. Nutrients, 17;11(7):1630. https://doi.org/ 10.3390/nu11071630
  • Luo Y., Zeng B., Zeng L., Du X., Li B. & Huo R. (2018). Gut microbiota regulates mouse behaviors through glucocorticoid receptor pathway genes in the hippocampus. Translational psychiatry, 7;8(1):187. https://doi.org/ 10.1038/s41398-018-0240-5
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  • Wasilewska J. & Klukowski M. (2015). Gastrointestinal symptoms and autism spectrum disorder: links and risks- a possible new overlap syndrome. Pediatric Health, Medicine and Therapeutics, 6:153-166. https://doi.org/ 10.2147/PHMT.S85717
  • Dunn A.B., Jordan S., Baker B.J. & Carlson N.S. (2017). The Maternal Infant Microbiome: Considerations for Labor and Birth. MCN The American Journal of Maternal Child Nursing, 42(6):318-325. https://doi.org/ 10.1097/NMC.0000000000000373
  • Suganya K. & Koo B.S. (2020). Gut-Brain Axis: Role of Gut Microbiota on Neurological Disorders and How Probiotics/Prebiotics Beneficially Modulate Microbial and Immune Pathways to Improve Brain Functions. International journal of molecular sciences, 21(20):7551. https://doi.org/ 10.3390/ijms21207551
  • Chowdhury M.A., Hossain N., Kashem M.A., Shahid M.A. & Alam A. (2020). Immune response in COVID-19: A review. Journal of infection prevention, 13(11):1619-1629. https://doi.org/ 10.1016/j.jiph.2020.07.001
  • Farsi Y., Tahvildari A., Arbabi M., Vazife F., Sechi L.A. & Shahidi Bonjar A.H. (2022). Diagnostic, Prognostic, and Therapeutic Roles of Gut Microbiota in COVID-19: A Comprehensive Systematic Review. Frontiers in cellular and infection microbiology, 4;12:804644. https://doi.org/ 10.3389/fcimb.2022.804644
  • Gagliardi A., Totino V., Cacciotti F., Iebba V., Neroni B. & Bonfiglio G. (2018). Rebuilding the Gut Microbiota Ecosystem. International journal of environmental health research, 7;15(8):1679. https://doi.org/
  • Sun Z., Song Z.G., Liu C., Tan S., Lin S., Zhu J. Et al. (2022). Gut microbiome alterations and gut barrier dysfunction are associated with host immune homeostasis in COVID-19 patients. BMC Medicine, 20;20(1):24. https://doi.org/ 10.1186/s12916-021-02212-0
  • Somsouk M., Estes J.D., Deleage C., Dunham R.M., Albright R. & Inadomi J.M. (2015). Gut epithelial barrier and systemic inflammation during chronic HIV infection. AIDS, 29(1):43-51. https://doi.org/
  • Gold J.E., Okyay R.A., Licht W.E. & Hurley D.J. (2021). Investigation of Long COVID Prevalence and Its Relationship to Epstein-Barr Virus Reactivation. Pathogens, 17;10(6):763. https://doi.org/ 10.3390/pathogens10060763
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  • D'Andrea G. (2015). Quercetin: A flavonol with multifaceted therapeutic applications? Fitoterapia, 106:256-71. https://doi.org/ 10.1016/j.fitote.2015.09.018
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  • Vázquez-Torres A. & Bäumler A.J. (2016). Nitrate, nitrite and nitric oxide reductases: from the last universal common ancestor to modern bacterial pathogens. Current Opinion in Microbiology, 29:1-8. https://doi.org/ 10.1016/j.mib.2015.09.002
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  • Madempudi R.S., Ahire JJ, Neelamraju J, Tripathi A. & Nanal S. (2019). Randomized clinical trial: the effect of probiotic Bacillus coagulans Unique IS2 vs. placebo on the symptoms management of irritable bowel syndrome in adults. Scientific reports, 21;9(1):12210. https://doi.org/ 10.1038/s41598-019-48554-x
  • Liu Q., Mak J.W.Y., Su Q., Yeoh Y.K., Lui G.C. & Ng S.S.S. (2022). Gut microbiota dynamics in a prospective cohort of patients with post-acute COVID-19 syndrome. Gut, 71(3):544-552. https://doi.org/ 10.1136/gutjnl-2021-325989
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  • Chowdhury M.A., Hossain N., Kashem M.A., Shahid M.A. & Alam A. (2020). Immune response in COVID-19: A review. Journal of infection prevention, 13(11):1619-1629. https://doi.org/ 10.1016/j.jiph.2020.07.001
  • Dill-McFarland K.A., Tang Z.Z., Kemis J.H., Kerby R.L., Chen G. & Palloni A. (2019). Close social relationships correlate with human gut microbiota composition. Scientific reports, 24;9(1):703. https://doi.org/ 10.1038/s41598-018-37298-9
  • Jin X., Lian J.S., Hu J.H., Gao J., Zheng L. & Zhang Y.M. (2020). Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms. Gut, 69(6):1002-1009. https://doi.org/ 10.1136/gutjnl-2020-320926
  • Suárez-Reyes A. & Villegas-Valverde C.A. (2021). Implications of Low-grade Inflammation in SARS-CoV-2 Immunopathology. MEDICC Review, 23(2):42. https://doi.org/ 10.37757/MR2021.V23.N2.4
  • Yeoh Y.K., Zuo T., Lui G.C., Zhang F. & Liu Q. (2021). Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19. Gut, 70(4):698-706. https://doi.org/10.1136/gutjnl-2020-323020
Toplam 89 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Solunum Hastalıkları
Bölüm Review Articles
Yazarlar

Kayhan Özkan 0000-0002-5956-093X

Şerif Demir

Yayımlanma Tarihi 19 Mayıs 2024
Gönderilme Tarihi 21 Aralık 2023
Kabul Tarihi 17 Nisan 2024
Yayımlandığı Sayı Yıl 2024 Cilt: 41 Sayı: 2

Kaynak Göster

APA Özkan, K., & Demir, Ş. (2024). Can the gastrointestinal system alter liver damage caused by COVID-19?. Journal of Experimental and Clinical Medicine, 41(2), 397-406.
AMA Özkan K, Demir Ş. Can the gastrointestinal system alter liver damage caused by COVID-19?. J. Exp. Clin. Med. Mayıs 2024;41(2):397-406.
Chicago Özkan, Kayhan, ve Şerif Demir. “Can the Gastrointestinal System Alter Liver Damage Caused by COVID-19?”. Journal of Experimental and Clinical Medicine 41, sy. 2 (Mayıs 2024): 397-406.
EndNote Özkan K, Demir Ş (01 Mayıs 2024) Can the gastrointestinal system alter liver damage caused by COVID-19?. Journal of Experimental and Clinical Medicine 41 2 397–406.
IEEE K. Özkan ve Ş. Demir, “Can the gastrointestinal system alter liver damage caused by COVID-19?”, J. Exp. Clin. Med., c. 41, sy. 2, ss. 397–406, 2024.
ISNAD Özkan, Kayhan - Demir, Şerif. “Can the Gastrointestinal System Alter Liver Damage Caused by COVID-19?”. Journal of Experimental and Clinical Medicine 41/2 (Mayıs 2024), 397-406.
JAMA Özkan K, Demir Ş. Can the gastrointestinal system alter liver damage caused by COVID-19?. J. Exp. Clin. Med. 2024;41:397–406.
MLA Özkan, Kayhan ve Şerif Demir. “Can the Gastrointestinal System Alter Liver Damage Caused by COVID-19?”. Journal of Experimental and Clinical Medicine, c. 41, sy. 2, 2024, ss. 397-06.
Vancouver Özkan K, Demir Ş. Can the gastrointestinal system alter liver damage caused by COVID-19?. J. Exp. Clin. Med. 2024;41(2):397-406.