Risk factors for lymph node involvement in early stage cervical cancer A retrospective cohort study

Year 2025, Volume: 42 Issue: 1, 1 - 4, 28.03.2025

Umut Erkok Vakkas Korkmaz , Esra Keles , Koray Aslan , Bülent Özdal , Adil Barut

Abstract

One of the most important prognostic factors in cervical cancer is lymph node involvement that affects disease-free survival and plays an important role in the treatment. This study aimed to determine the factors affecting lymph node involvement in early stage cervical cancer. A total of 169 cervical cancer patients with stage IA2-IIA2 were enrolled. Age, histologic subtype, deep stromal invasion (DSI), largest tumor diameter (LTD), lymphovascular space invasion (LVSI), vaginal surgical margin, ovarian metastasis status, parametrial involvement, lymph node count and presence of metastasis were retrospectively reviewed. All of these parameters are divided into two groups: LNM positive (group 1) and negative (group 2). The median age of the patients was 52 (26-77) years. In the univariate regression analysis; LVSI (p <0.001), DSI (p=0.018), parametrial involvement (p = 0.001), and vaginal surgical margin positivity (p = 0.020) were in statistically significant correlations with lymph node involvement. In multivariate regression analysis, LVSI [51/118 (43.2%) vs 7/51 (13.7%), OR = 3.9, p = 0.003] and parametrial involvement [(16/24 (66.6%) vs 42/145 (28.9%), OR = 3.9, p = 0.009] were the independent risk factors for lymph node metastasis. LVSI and parametrial involvement are two crucial risk factors for lymph node metastasis in patients diagnosed with early-stage cervical cancer.

Keywords

cervical cancer, ; lymph-vascular space invasion, lymph node metastasis

Ethical Statement

The database management in accordance with privacy legislation and the presented study in accordance with the ethical principle of the Declaration of Helsinki. Ethical approval for this study was obtained by the the Board of Medical Speciality Education at the University of Health Sciences, Zekai Tahir Burak Women's Research and Training Hospital (Approval number:8, 05.12.2017). The work has not been published previously and it is not under consideration for publication elsewhere.

Supporting Institution

None.

Thanks

None.

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