Yıl 2021, Cilt 14 , Sayı 1, Sayfalar 185 - 190 2021-01-04

Aberran sağ subklavyen arter: down sendromu ve konjenital kalp hastalığı için güçlü bir belirteç midir?
Aberrant right subclavian artery: is a strong marker for Down syndrome and congenital heart disease?

Emine DEMİR [1] , Emre EKMEKCİ [2] , Sefa KELEKCI [3]


Amaç: Fetal aberran sağ subklavyen arter (ARSA) ile Down sendromu arasındaki ilişki uzun zamandır bilinmektedir. Çalışmamızın amacı popülasyonumuzdaki ARSA insidansını ve Down sendromu ve konjenital kalp hastalıkları (KKH) ile ilişkisini belirlemektir. Gereç ve Yöntem: 2015-2018 yılları arasında üçüncü basamak merkezde prenatal tanı için 3150 gebeye fetal ekokardiyografi yapıldı. ARSA varlığı, fetal ekokardiyografi sırasında transvers 3 damar trakea planında renkli Doppler sonografide görüntülenmesi ile doğrulandı. Çalışmamızda ARSA'nın sıklığı ve Down sendromu ile korelasyonu araştırıldı. Bulgular: 3150 hasta arasında 42 fetüste (% 1.3) ARSA, 36 fetüste (% 1.14) izole ARSA saptandı. Down sendromlu dokuz fetüsten iki hastada (% 22.2) ARSA pozitifti. ARSA, KKH olan fetüslerden sadece birinde pozitifti (% 4.1). İzole ARSA'nın Down sendromu ve CHD için pozitif olasılık oranları sırasıyla 0.73 ve 3.81 idi. Sonuç: Olgu serimizde, prenatal ARSA'nın saptanması Down sendromu için tek başına güçlü bir marker gibi görünmemektedir ve izole ARSA, KKH ile zayıf bir ilişki göstermektedir.
Purpose: The association between fetal aberrant right subclavian artery (ARSA) and Down syndrome has been known for a long time. The aim of our study was to determine the incidence of ARSA in our population and its association with Down syndrome and congenital heart diseases (CHD). Materials and Methods: Between 2015-2018 years, fetal echocardiography was performed in 3150 pregnant population at a tertiary referral center for prenatal diagnosis. The presence of ARSA was verified by visualization of the transverse 3-vessel trachea view by color Doppler sonography during fetal echocardiography. The frequency of ARSA and its correlation with Down syndrome were investigated in our study. Results: Among the 3150 patients, an ARSA was detected in 42 fetuses (1.3%) and isolated ARSA was detected in 36 fetuses (1.14%). Of nine fetuses with Down syndrome, ARSA was positive in two (22.2%). ARSA was positive in only one of the fetuses with CHD (4.1%). The positive likelihood ratios of isolated ARSA for Down syndrome and CHD were 0.73 and 3.81, respectively. Conclusion: In our case series, prenatal detection of ARSA does not appear to be a strong marker alone of Down syndrome and the isolated ARSA shows a weak association with CHD.
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Birincil Dil en
Konular Kadın Hastalıkları ve Doğum
Yayınlanma Tarihi Ocak 2021
Bölüm Araştırma Makalesi
Yazarlar

Orcid: 0000-0003-3799-3432
Yazar: Emine DEMİR (Sorumlu Yazar)
Kurum: DENİZLİ DEVLET HASTANESİ
Ülke: Turkey


Orcid: 0000-0003-2494-3073
Yazar: Emre EKMEKCİ
Kurum: ŞANLIURFA EĞİTİM VE ARAŞTIRMA HASTANESİ
Ülke: Turkey


Orcid: 0000-0002-9952-3068
Yazar: Sefa KELEKCI
Kurum: İZMİR KATİP ÇELEBİ ÜNİVERSİTESİ, TIP FAKÜLTESİ, CERRAHİ TIP BİLİMLERİ BÖLÜMÜ, KADIN HASTALIKLARI VE DOĞUM ANABİLİM DALI, PERİNATOLOJİ BİLİM DALI
Ülke: Turkey


Tarihler

Yayımlanma Tarihi : 4 Ocak 2021

Bibtex @araştırma makalesi { patd753921, journal = {Pamukkale Tıp Dergisi}, issn = {}, eissn = {1308-0865}, address = {Pamukkale Üniversitesi Tıp Fakültesi Eğitim Blokları Kınıklı kampüsü 20070 Kınıklı, Denizli}, publisher = {Pamukkale Üniversitesi}, year = {2021}, volume = {14}, pages = {185 - 190}, doi = {10.31362/patd.753921}, title = {Aberrant right subclavian artery: is a strong marker for Down syndrome and congenital heart disease?}, key = {cite}, author = {Demi̇r, Emine and Ekmekci̇, Emre and Kelekcı, Sefa} }
APA Demi̇r, E , Ekmekci̇, E , Kelekcı, S . (2021). Aberrant right subclavian artery: is a strong marker for Down syndrome and congenital heart disease? . Pamukkale Tıp Dergisi , 14. Cilt 1. Sayı , 185-190 . DOI: 10.31362/patd.753921
MLA Demi̇r, E , Ekmekci̇, E , Kelekcı, S . "Aberrant right subclavian artery: is a strong marker for Down syndrome and congenital heart disease?" . Pamukkale Tıp Dergisi 14 (2021 ): 185-190 <https://dergipark.org.tr/tr/pub/patd/issue/56734/753921>
Chicago Demi̇r, E , Ekmekci̇, E , Kelekcı, S . "Aberrant right subclavian artery: is a strong marker for Down syndrome and congenital heart disease?". Pamukkale Tıp Dergisi 14 (2021 ): 185-190
RIS TY - JOUR T1 - Aberrant right subclavian artery: is a strong marker for Down syndrome and congenital heart disease? AU - Emine Demi̇r , Emre Ekmekci̇ , Sefa Kelekcı Y1 - 2021 PY - 2021 N1 - doi: 10.31362/patd.753921 DO - 10.31362/patd.753921 T2 - Pamukkale Tıp Dergisi JF - Journal JO - JOR SP - 185 EP - 190 VL - 14 IS - 1 SN - -1308-0865 M3 - doi: 10.31362/patd.753921 UR - https://doi.org/10.31362/patd.753921 Y2 - 2020 ER -
EndNote %0 Pamukkale Tıp Dergisi Aberrant right subclavian artery: is a strong marker for Down syndrome and congenital heart disease? %A Emine Demi̇r , Emre Ekmekci̇ , Sefa Kelekcı %T Aberrant right subclavian artery: is a strong marker for Down syndrome and congenital heart disease? %D 2021 %J Pamukkale Tıp Dergisi %P -1308-0865 %V 14 %N 1 %R doi: 10.31362/patd.753921 %U 10.31362/patd.753921
ISNAD Demi̇r, Emine , Ekmekci̇, Emre , Kelekcı, Sefa . "Aberrant right subclavian artery: is a strong marker for Down syndrome and congenital heart disease?". Pamukkale Tıp Dergisi 14 / 1 (Ocak 2021): 185-190 . https://doi.org/10.31362/patd.753921
AMA Demi̇r E , Ekmekci̇ E , Kelekcı S . Aberrant right subclavian artery: is a strong marker for Down syndrome and congenital heart disease?. Pamukkale Tıp Dergisi. 2021; 14(1): 185-190.
Vancouver Demi̇r E , Ekmekci̇ E , Kelekcı S . Aberrant right subclavian artery: is a strong marker for Down syndrome and congenital heart disease?. Pamukkale Tıp Dergisi. 2021; 14(1): 185-190.
IEEE E. Demi̇r , E. Ekmekci̇ ve S. Kelekcı , "Aberrant right subclavian artery: is a strong marker for Down syndrome and congenital heart disease?", Pamukkale Tıp Dergisi, c. 14, sayı. 1, ss. 185-190, Oca. 2021, doi:10.31362/patd.753921