Review

The Relationship Between Euthyroid, Hyperthyroid, Hypothyroid, and Type 2 Diabetes

Volume: 3 Number: 4 October 9, 2023

The Relationship Between Euthyroid, Hyperthyroid, Hypothyroid, and Type 2 Diabetes

Abstract

Diabetes mellitus (DM) and thyroid dysfunction, which have a significant incidence worldwide, are the most common endocrine system disorders that occur together in patients. Our aim is to explain these 2 diseases with high incidence and the relationship between these 2 diseases. Thyroid hormones (TH) are essential hormones that govern body metabolism. Thyroid hormone changes are thought to be effective on the pathogenesis of DM. Diabetes mellitus treatments can be beneficial, as TH changes may contribute to the pathogenesis of DM. However, more research needs to be done. This lack of information limits potential biomarkers and targets for diagnosis, prognosis, and the development of new DM treatments. The limitations of the use of natural THs have led to the development of synthetic hormones called thyromimetics. However, most of the thyromimetics tested so far have been ineffective or toxic.

Keywords

References

  1. 1. Oguntibeju OO. Type 2 diabetes mellitus, oxidative stress and inflammation: examining the links. Int J Physiol Pathophysiol Pharmacol. 2019;11(3):45-63.
  2. 2. Cole JB, Florez JC. Genetics of diabetes mellitus and diabetes complications. Nat Rev Nephrol. 2020;16(7):377-390. [CrossRef]
  3. 3. Forouhi NG, Wareham NJ. Epidemiology of diabetes. Medicine (Abingdon). 2014;42(12):698-702. [CrossRef]
  4. 4. Redondo MJ, Hagopian WA, Oram R, et al. The clinical consequences of heterogeneity within and between different diabetes types. Diabetologia. 2020;63(10):2040-2048. [CrossRef]
  5. 5. Ozougwu O. The pathogenesis and pathophysiology of type 1 and type 2 diabetes mellitus. J Physiol Pathophysiol. 2013;4(4):46-57.
  6. 6. Liu YC, Yeh CT, Lin KH. Molecular functions of thyroid hormone signaling in regulation of cancer progression and anti-apoptosis. Int J Mol Sci. 2019;20(20):4986.[CrossRef]
  7. 7. Gereben B, Zavacki AM, Ribich S, et al. Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling. Endocr Rev. 2008;29(7):898-938. [CrossRef]
  8. 8. Thvilum M, Brandt F, Brix TH, Hegedüs L. A review of the evidence for and against increased mortality in hypothyroidism. Nat Rev Endocrinol. 2012;8(7):417-424. [CrossRef]

Details

Primary Language

Turkish

Subjects

Pharmacology and Pharmaceutical Sciences (Other)

Journal Section

Review

Publication Date

October 9, 2023

Submission Date

July 3, 2023

Acceptance Date

September 19, 2023

Published in Issue

Year 2023 Volume: 3 Number: 4

APA
Kutlu, Z., & Kamacı, A. D. (2023). The Relationship Between Euthyroid, Hyperthyroid, Hypothyroid, and Type 2 Diabetes. Pharmata, 3(4), 105-111. https://doi.org/10.5152/Pharmata.2023.23009
AMA
1.Kutlu Z, Kamacı AD. The Relationship Between Euthyroid, Hyperthyroid, Hypothyroid, and Type 2 Diabetes. Pharmata. 2023;3(4):105-111. doi:10.5152/Pharmata.2023.23009
Chicago
Kutlu, Zerrin, and Afra Dilay Kamacı. 2023. “The Relationship Between Euthyroid, Hyperthyroid, Hypothyroid, and Type 2 Diabetes”. Pharmata 3 (4): 105-11. https://doi.org/10.5152/Pharmata.2023.23009.
EndNote
Kutlu Z, Kamacı AD (October 1, 2023) The Relationship Between Euthyroid, Hyperthyroid, Hypothyroid, and Type 2 Diabetes. Pharmata 3 4 105–111.
IEEE
[1]Z. Kutlu and A. D. Kamacı, “The Relationship Between Euthyroid, Hyperthyroid, Hypothyroid, and Type 2 Diabetes”, Pharmata, vol. 3, no. 4, pp. 105–111, Oct. 2023, doi: 10.5152/Pharmata.2023.23009.
ISNAD
Kutlu, Zerrin - Kamacı, Afra Dilay. “The Relationship Between Euthyroid, Hyperthyroid, Hypothyroid, and Type 2 Diabetes”. Pharmata 3/4 (October 1, 2023): 105-111. https://doi.org/10.5152/Pharmata.2023.23009.
JAMA
1.Kutlu Z, Kamacı AD. The Relationship Between Euthyroid, Hyperthyroid, Hypothyroid, and Type 2 Diabetes. Pharmata. 2023;3:105–111.
MLA
Kutlu, Zerrin, and Afra Dilay Kamacı. “The Relationship Between Euthyroid, Hyperthyroid, Hypothyroid, and Type 2 Diabetes”. Pharmata, vol. 3, no. 4, Oct. 2023, pp. 105-11, doi:10.5152/Pharmata.2023.23009.
Vancouver
1.Zerrin Kutlu, Afra Dilay Kamacı. The Relationship Between Euthyroid, Hyperthyroid, Hypothyroid, and Type 2 Diabetes. Pharmata. 2023 Oct. 1;3(4):105-11. doi:10.5152/Pharmata.2023.23009

Cited By

Content of this journal is licensed under a Creative Commons Attribution NonCommercial 4.0 International License

29929