Are 25-hydroxyvitamin D deficiency and Helicobacter pylori infection more common in obese people?

Abstract

Introduction:Helicobacter pylori (Hp)infection is widespread in the world.Hp can lead to chronic gastritis, chronic inflammation, and immune response.Immune cytokines, adipokines that occur with an immune response have been associated with insulin resistance, and obesity has been associated with 25-hydroxy vitamin D deficiency.Our study aimed to show the significant relationship between Hp positivity and 25-hydroxy vitamin D deficiency in obese individuals. Materials and Methods:Patients over the age of 20 who applied to the internal medicine department with dyspeptic complaints between January 1, 2019, and December 31, 2019, were divided into three groups as 18-24.9 (normal weight), 25-29.9 (overweight), 30-39.9 (obese) according to their body mass indexes (BMI).Urea breath test for Hp infection, 25-hydroxyvitamin D and other biochemical parameters, anthropometric measurements, education levels, systemic diseases, smoking history of patients who did not use proton pump inhibitor, and 25-hydroxyvitamin D for the last six months were retrospectively analyzed from the patient file archive. Results:The study was carried out with 632 cases, 51.6% (n = 326) of the patients were male, and 48.4% (n = 306) were female.The ages of the cases ranged from 21 to 65, and the mean age was 43.97 ± 12.87 years.Body mass index measurements of the cases included in the study ranged between 18.8 and 39.9 kg/m2, with a mean of 28.02 ± 4.98 kg/m2; %31.3% (n = 198) were normal weight, 35.5% (n = 224) were overweight and 33.2% (n = 210) were obese.A statistically significant difference was found between the Hp incidence rates according to the body mass index levels of the groups(p=0.001; p<0.01). In mutual evaluations, the rate of Hp incidence in obese cases was higher than normal and overweight cases (p = 0.001; p = 0.001; p <0.01, respectively).The incidence of Hp in overweight cases is also higher than in normal-weight cases.A statistical difference was observed in the 25 hydroxyvitamin D values of the cases according to the body mass index levels(p=0.001; p<0.01).As a result of mutual comparisons, 25-hydroxyvitamin D measurements of obese cases were lower than those of overweight and normal-weight subjects (p = 0.001; p = 0.001; p <0.01, respectively).The 25-hydroxyvitamin D measurements of overweight patients were lower than those of normal weight (p = 0.001; p <0.01). Conclusion:We investigated whether Hp infection and vitamin D deficiency are more common in obese people than in normal or overweight people.We found that Hp infection was more common in individuals with vitamin D deficiency and obesity.We think that vitamin D deficiency should be eliminated for eradication treatment in Hp positive individuals, and Hp should be investigated closely in obese people.We want to state that the study will contribute to studies on the relationship between Hp and vitamin D deficiency in obese people in the literature.

Keywords

• Obesity
• 25-hydroxyvitamin deficiency
• helicobacter pylori

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