A new analytical method for the determination of iron content in drugs

Abstract

Objective: This study is based on the determination of iron, which is found in iron-containing drugs, by a simple, precise, and economical method. Methods: In our study, Flame Atomic Absorption Spectroscopy (FAAS) was used for measurements due to its ease of use and low cost. The disadvantage of FAAS in terms of insufficient precision was turned into an advantage by adding a slotted quartz tube (SQT) to the device and using an enrichment method. Accordingly, a solid-phase microextraction (SPME) method interconnected with slotted quartz tube-flame atomic absorption spectrometry (SQT-FAAS) was developed. Results: While the LOD value for Fe³⁺ ions measured by FAAS was 108.0 mg/L, the LOD value was determined to be 1.12 mg/L with the method developed using CoMNP-SPME-SQT. This indicates a 96.43-fold improvement in the LOD. Conclusion: The developed Co-MNP-DSPE-SQT-FAAS method has been successfully and easily applied for the determination of iron in iron-containing drug samples. These results indicate that the method can also be applied to different samples.

Keywords

• Magnetic Nanoparticle-Solid Phase Microextraction (MNPSPME)
• Iron
• Drug
• Flame Atomic Absorption Spectroscopy (FAAS)

İlaçlardaki Demir İçeriğinin Belirlenmesi için Yeni Bir Analitik Yöntem

Abstract

Amaç: Bu çalışma, demir içeren ilaçlarda bulunan demirin basit, hassas ve ekonomik bir yöntemle belirlenmesine dayanmaktadır. Yöntemler: Çalışmamızda, kullanım kolaylığı ve düşük maliyeti nedeniyle ölçümler için Alevli Atomik Absorpsiyon Spektroskopisi (FAAS) kullanılmıştır. FAAS'in yetersiz hassasiyeti dezavantajı, cihaza yarıklı kuvars tüp (SQT) eklenerek ve bir zenginleştirme yöntemi kullanılarak avantaja dönüştürülmüştür. Buna göre, yarıklı kuvars tüp-alevli atomik absorpsiyon spektrometresi (SQT-FAAS) ile bağlantılı katı faz mikroekstraksiyon (SPME) yöntemi geliştirilmiştir. Bulgular: FAAS ile ölçülen Fe³⁺ iyonları için belirlenen LOD (tespit sınırı) değeri 108,0 mg/L iken, CoMNP-SPME-SQT yöntemi ile geliştirilen yöntemde LOD değeri 1,12 mg/L olarak belirlenmiştir. Bu, LOD değerinde 96,43 kat iyileşme sağlandığını göstermektedir. Sonuç: Geliştirilen Co-MNP-DSPE-SQT-FAAS yöntemi, demir içeren ilaç örneklerinde demirin belirlenmesi için başarılı ve kolay bir şekilde uygulanmıştır. Bu sonuçlar, yöntemin farklı örneklere de uygulanabileceğini göstermektedir.

Keywords

• Manyetik Nanoparçacık-Katı Faz Mikroekstraksiyonu (MNPSPME)
• Demir
• İlaç
• Alevli Atomik Absorpsiyon Spektroskopisi (FAAS)

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