Reaktif Hiperplazi ve Rekürrent Tonsillitlerde Lusigenin - Serbest Oksijen Radikallerinin Karşılaştırılması

Yıl 2019, Cilt: 1 Sayı: 1, 15 - 19, 01.11.2019

Ali Seyed Resuli

https://doi.org/10.38175/phnx.615142

Cited By: 1

Öz

Giriş ve Amaç: kronik tonsilite bağlı Tonsillektomi
(T), Kulak Burun Boğaz hekimlerinin en sık yaptıkları ameliyatlardandır. Halen
kronik tonsillit ve tonsil hipertrofisi patogenizindeki faklılıklar tam olarak
bilinmemektedir.  Tonsil hipertrofisi ve
kronik tonsillit hastalarında serbest okisjen radikallerinin seviyelerinin
karşılaştırılması ve serbest okisjen radikallerinin kronik tonsiillit
patogenezindeki rolünün araştırılması bu çalışmada amaçlanmıştır.

Gereç ve yöntem: Çalışmaya Paradise kriterlerine göre
Tonsillektomi (T) endikasyonu konulan ve opere edilen 40 hasta alındı.
Operasyon materyallerine histopatolojik inceleme ve serbest oksijen
radikalleriden süperoksit ölçümleri yapıldı.

Bulgular: Histopatolojik bulgulara göre; 28
(%70) hastadan oluşan aktif yada kronik tonsilitli diğeri ise 12 (%30) hastadan
oluşan reaktif folliküler hiperplazili olarak iki gruba ayrıldı. Kronik
tonsilitli grubun lusigenin-serbest oksijen radikal (Luc-SOR) değeri 82.29+-32.3 Auc,  reaktif 
folliküler hiperplazi’li  grubun
ise 50.76+-7.95 Auc bulundu. Luc-SOR değeri karşılaştırıldığında kronik
tonsillitli grupta anlamlı derecede (p=0.001) yüksek olduğu belirlendi.

Sonuç: Serbest
oksijen radikalleri tonsiller patolojilerde önemli rol oynamaktadır. Tonsil
hipertrofisi ve kronik tonsillit hastalarının tonsil dokusundan ölçülen Luc-SOR
değerlerinin farklı olması bu iki hastalığın patogenezinin de farklı olduğunu
göstermektedir.

Anahtar Kelimeler

Tonsillektomi, Kronik Tonsilit, Serbest Oksijen Radikalleri

A Comparison of Lucigenin - Free Oxygen Radicals in Reactive Hyperplasia and Recurrent Tonsillitis

Öz

Aim and Background: Today, tonsillectomy (T) used for chronic tonsillitis
is among the most common surgery type that ear, nose, and throat physicians
perform. The differences in the pathogenesis of chronic tonsillitis and tonsil
hypertrophy are still unknown. This study aimed to compare the levels of free
oxygen radicals in patients with tonsil hypertrophy and chronic tonsillitis and
to investigate the role of free oxygen radicals in the pathogenesis of chronic
tonsillitis.

Materials and Method: The study included 40 patients who had chronic
tonsillitis indications based on Paradise criteria, and T was performed.
Operation materials were histopathologically examined, and their free oxygen
radicals (FOR) levels were measured.

Results:
Based on the histopathological results, the participants were divided into two
groups: one including 28 (70%) patients who had active or chronic tonsillitis,
the other including 12 (30%) patients with reactive follicular
hyperplasia.  Lucigenin - free oxygen
radicals (Luc-FOR) levels of the group with chronic tonsillitis and that of the
group with reactive follicular hyperplasia were 82.29±32.3 Auc and 50.76±7.95
Auc, respectively.  Luc-FOR values were
found to be significantly higher in the group with chronic tonsillitis
(p=0.001).

Conclusion: Free oxygen radicals play an essential role in
tonsillar pathologies. Differences in the Luc-FOR levels measured from
tonsillar tissue in patients with tonsil hypertrophy and chronic tonsillitis
demonstrate that the pathogenesis of these two diseases is different.

Anahtar Kelimeler

tonsillectomy, chronic tonsillitis, free oxygen radicals

Kaynakça

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