Çörek Otu Yağının Bilimsel ve Sağlıklı Yaşam Üzerine Tıbbi ve Terapötik Etkileri

Yıl 2023, Cilt: 5 Sayı: 1, 6 - 9, 01.03.2023

Mohamad El Dhaybi Deniz Mesutoğlu Dilara Rana Biçer

https://doi.org/10.38175/phnx.1134490

Öz

Çörek otu (Nigella sativa), Ranunculaceae familyasına ait otsu bir bitkidir. Çörek otu tohumları tatlılar, içecekler ve ekmek, lavaş, poğaça, simit gibi unlu mamüllerde kullanılmaktadır. Çok sayıda hastalığı tedavi etmek ve önlemek için geleneksel ve modern tıpta yaygın olarak kullanılmaktadır. Bu bitkinin tohumları, sabit ve uçucu yağlar ile alkaloidler, proteinler, saponin ve diğer kimyasal bileşenleri içerir. Biyolojik özelliklerin çoğu, uçucu yağın önemli bir bileşeni olan ve sabit yağda bulunan timokinondan kaynaklanır. Birçok araştırmacı bu yağın farmakolojik özelliklerini incelemektedir. Yapılan çalışmalar, çörek otu yağının iltihaplanma, kanser, karaciğer bozuklukları ve diğer hastalıklara karşı etkili olduğunu göstermektedir. Bu bilimsel araştırmalar ve sonuçlarına göre, insanlarda pek çok hastalığın tedavisinde çörek otu bitkisinin potansiyel kullanımının desteklendiği görülmektedir.

Anahtar Kelimeler

Çörek otu, Geleneksel Tıpı, Timokinon, Farmakolojik Özellikler

Medical and Therapeutic Effects of Black Seed oil on The Science And Health Life

Öz

Black Cumin (Nigella sativa) is a herbaceous plant which belongs to the Ranunculaceae family. The seeds of black cumin have been used in some foods such as confectionery, drinks and bakery products. It’s widely used in traditional and modern medicine to treat and prevent a high number of diseases. The seeds of this plant contain fixed and essential oils as well alkaloids, proteins, saponin, and other chemical components. Most biological properties result from thymoquinone, a major component of the essential oil and present in fixed oil. Many researchers are interested in studying the pharmacological properties of this oil, and have shown its effect against inflammation, cancer, hepatic disorders and other diseases. A huge number of studies support the potential use of this plant in human therapy.

Anahtar Kelimeler

Nigella Sativa, Traditionnal Medicine, Thymoquinone, Pharmacological Properties

Kaynakça

• Ghedira K. La nigelle cultivée: Nigella sativa L. (Ranunculaceae) Cultivated black cumin: Nigella sativa L. (Ranunculaceae). Phytothérapie. 2006;(4):220-6.
• Saidi, B. La graine de Nigelle : remède sacré ou sacré remède? France:La Ruche, 2011; pp. 7-30
• Bittkau C, Comes H P. Evolutionary processes in a continental island system: molecular phylogeography of the Aegean Nigella arvensis alliance (Ranunculaceae) inferred from chloroplast DNA. Molecular Ecology. 2005;(14):4065- 83.
• Botnick I, Xue W, Bar E, Ibdah M, Schwartz A, Joel DM, et al. Distribution of Primary and Specialized Metabolites in Nigella sativa Seeds, a Spice with Vast Traditional and Historical Uses. Molecules. 2012;17(9):10159‐77.
• Alami S. La phytothérapie ancestrale actuelle et d’avenir. Thèse de Médecine, Casablanca; 1989.
• Nassimi M. La médecine moderne et la science du prophète (éd. 3e édition). Damas: Acharika;1984.
• Ibn-Sina. La loi de la médecine, le livre des médicaments et des plantes. Beyrouth: Maktab Attollab;1972.
• Kunnumakkara AB, Koca C, Dey, S Gehlot, Yodkeeree PS, Danda D, Sung B, Aggarwal BB. Traditional Uses of Spices: An Overview. In: Aggarwal BB, Kunnumakkara AB. eds. Molecular targets and therapeutic uses of spices: Modern uses for ancient medicine. USA:World Scientific Publishing Co.; 2009. pp. 1-24.
• Baser K, Honda G, Miki W. Herb drugs and herbalists in Turkey. Institute for the study of languages and cultures of Asia and Africa, Tokyo;1986,287-8.
• Srinivasan C. Cumin (Cuminum cyminum) and black cumin (Nigella sativa) seeds: Traditional uses, chemical constituents, and nutraceutical effects. Food Qual Safet. 2018;2(1):1-16.
• Ali B, Biunden,G. Pharmacological and Toxicological properties of Nigella sativa. Phytother Res. 2002;15:59-69.
• Ramadan M. Nutritional value, functional properties and nutraceutical applications of black cumin (Nigella sativa L.): an overview. Int J Food Sci Technol. 2007;42:1208-1218.
• Abhar H, Abdallah D, Saleh S. Gastroprotective activity of Nigella sativa oil and its constituent, thymoquinone, against gastric mucosal injury induced by ischaemia/reperfusion in rats. J Ethnophamacol. 2003;84:251-8.
• Mahgoub A. Thymoquinone protects against experimental colitis in rats. Toxicol Lett. 2003;143:133-43.
• Gharably N, Badary O, Nagi M, Shabanah O, Bekairi A. Protective effect of thymoquinone against carbon tetrachloride hepatotoxicity in mice. Res Comm Pharmacol Toxicol. 1997;2 (1/2):41-50.
• Salomi M, Nair S, Panikkar K. Inhibitory effects of Nigella sativa and saffron (Crocus sativus) on chemical carcinogenesis in mice. Nutr Cancer. 1991;16:67-72.
• Koka P, Mondal D, Schultz M, Abdel-Mageed A, Krıshna AC. Studies on molecular mechanisms of growth inhibitory effects of thymoquinone against prostate cancer cells: role of reactive oxygen species. Exp Biol Med. 2010;235:751-60.
• Hader A, Aqel M, Hasan Z. Hypoglycemic effect of the volatil oil of Nigella sativa seeds. Int J Pharmacol. 1993;31:96-100.
• Khan M. Chemical composition and medicinal properties of Nigella sativa Linn. Inflammopharmacology. 1999;7(1):15-35.
• Ragheb A, Attia A, Eldin W, Elbarbry FS, Shoker A. The protective effect of thymoquinone, an anti-oxydant and anti-inflammatory agent, against renal injury: A review. Saudi J Kidney Dis Transpl. 2009;20:742-52.
• Naggar T, Gomez-Serranıllos M, Carretero M, Vıllar A. Neuropharmacological activity of Nigella sativa L. extracts. J Ethnopharmacol. 2003;88:63-8.
• Kanter M, Coskun O, Kalaycı M, Buyukbas S, Cagavı F. Neuroprotective effects of Nigella sativa on experimental spinal cord injury in rats. Hum Exp Toxicol. 2006;25:127-33.