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Collagen type I alpha 1 (COL1A1) rs1800012 polymorphism in cyclists

Yıl 2020, Cilt 11, Sayı 2, 1 - 4, 29.05.2020

Öz

Purpose: We suggested that polymorphic differences affect the performance of cyclists. In this study we designed the experiment to identify collagen type I alpha 1 (COL1A1) rs1800012 polymorphism in cyclists. 

Methods: We isolated genomic DNA from buccal epithelial cells of 38 cyclists. We followed COL1A1 rs1800012 single nucleotide polymorphism genotyping technology protocol. We reported allele frequencies for rs1800012 gene variants of cyclists in our kohort. 

Results: Our results indicated the differences of the distribution of COL1A1 rs1800012 SNP between cyclists. The numbers and percentages of CC, AC and AA genotypes for rs1800012 polymorphism that we obtained were 24 (63%), 13 (34%) and 1 (3%), respectively. The distributions of C and A alleles were counted as 61 (80%) and 15 (20%).

Conclusions: There was difference in the genotype and also allele distribution between cyclists. Carriers of a C allele as compared to carriers of the allele A are more prone to cyclism. Larger homogenous cohorts may help clarify the association between COL1A1 rs1800012 polymorphism and physical performance.

Kaynakça

  • Chamberlain, C. S., Crowley, E., Hirohito, Kobayashi. (2011). Quantification of Collagen Organization and Extracellular Matrix Factors within the Healing Ligament. Microsc Microanal., 17(5), 779–787.
  • Chen, B., Xin-Yu, Z., Dong-Cai, H., Jha, R.K. and Liao-Bin, C. (2016). COL1A1 rs1800012 Polymorphism Associated with Anterior Cruciate Ligament Injuries: A Meta-Analysis. Remedy Open Access - Clinical Rheumatology, 30 Dec, Volume 1, Article 1035.
  • Collins, M., Posthumus, M., Schwellnus, M. (2010). The COL1A1 gene and acute soft tissue ruptures. Br. J. Sports Med., 44, 1063-1064.
  • Erduran, M., Altinisik, J., Meric, G., Ates, O., Ulusal, A.E. and Akseki, D. (2014). Is Sp1 binding site polymorphism within COL1A1 gene associated with tennis elbow? Gene, 537, 308-311.
  • Ficek, K., Cieszczyk, P., Kaczmarczyk, M., et al. (2013). Gene variants within the COL1A1 gene are associated with reduced anterior cruciate ligament injury in professional soccer players. J Sci Med Sport, 16, 396–400.
  • Marini, J.C. and Blissett, A.R. (2013). New genes in bone development: what’s new in osteogenesis imperfecta. The Journal of clinical endocrinology and metabolism, 98, 3095-3103.
  • Nordin, M., Lorenz, T., Campello, M. (2001). Basic Biomechanics of the Musculoskeletal System. Lippincott Williams and Wilkins; Biomechanics of tendons and ligament; electronic book chapter 4, pp.102-125.
  • Khoschnau, S., Melhus, H., Jacobson, A. (2008). Type I collagen alpha1 Sp1 polymorphism and the risk of cruciate ligament ruptures or shoulder dislocations. Am J Sports Med, 36(12), 2432–2436.
  • Posthumus, M., September, A.V., Keegan, M., et al. (2009). Genetic risk factors for anterior cruciate ligament ruptures: COL1A1 gene variant. Br J Sports Med, 43(5), 352–356.
  • Stepien-Slodkowska, M., Ficek, K., Eider, J., et al. (2013). The 1245 G/T polymorphisms in the collagen type I alpha 1 (col1a1) gene in polish skiers with anterior cruciate ligament injury. Biol Sport, 30(1), 57–60.
  • Ulucan, K., Yalcin, S., Akbas, B., Uyumaz, F., Konuk, M. (2014). Analysis of Solute Carrier Family 6 Member 4 Gene promoter polymorphism in young Turkish basketball players. The journal of Neurobehavioral Sciences, 1(2), 37-40.
  • Ulucan, K. (2016). Literature Review of Turkish Sportsmen in Terms of ACTN3 R577X Polymorphism. Clinical and Experimental Health Sciences, 6(1), 44-47.
  • Wang, C., Li, H., Chen, K., Wu, B., Liu, H. (2017). Association of polymorphisms rs1800012 in COL1A1 with sports-related tendon and ligament injuries: a meta-analysis. Oncotarget, 8, 27627–27634.

Yıl 2020, Cilt 11, Sayı 2, 1 - 4, 29.05.2020

Öz

Kaynakça

  • Chamberlain, C. S., Crowley, E., Hirohito, Kobayashi. (2011). Quantification of Collagen Organization and Extracellular Matrix Factors within the Healing Ligament. Microsc Microanal., 17(5), 779–787.
  • Chen, B., Xin-Yu, Z., Dong-Cai, H., Jha, R.K. and Liao-Bin, C. (2016). COL1A1 rs1800012 Polymorphism Associated with Anterior Cruciate Ligament Injuries: A Meta-Analysis. Remedy Open Access - Clinical Rheumatology, 30 Dec, Volume 1, Article 1035.
  • Collins, M., Posthumus, M., Schwellnus, M. (2010). The COL1A1 gene and acute soft tissue ruptures. Br. J. Sports Med., 44, 1063-1064.
  • Erduran, M., Altinisik, J., Meric, G., Ates, O., Ulusal, A.E. and Akseki, D. (2014). Is Sp1 binding site polymorphism within COL1A1 gene associated with tennis elbow? Gene, 537, 308-311.
  • Ficek, K., Cieszczyk, P., Kaczmarczyk, M., et al. (2013). Gene variants within the COL1A1 gene are associated with reduced anterior cruciate ligament injury in professional soccer players. J Sci Med Sport, 16, 396–400.
  • Marini, J.C. and Blissett, A.R. (2013). New genes in bone development: what’s new in osteogenesis imperfecta. The Journal of clinical endocrinology and metabolism, 98, 3095-3103.
  • Nordin, M., Lorenz, T., Campello, M. (2001). Basic Biomechanics of the Musculoskeletal System. Lippincott Williams and Wilkins; Biomechanics of tendons and ligament; electronic book chapter 4, pp.102-125.
  • Khoschnau, S., Melhus, H., Jacobson, A. (2008). Type I collagen alpha1 Sp1 polymorphism and the risk of cruciate ligament ruptures or shoulder dislocations. Am J Sports Med, 36(12), 2432–2436.
  • Posthumus, M., September, A.V., Keegan, M., et al. (2009). Genetic risk factors for anterior cruciate ligament ruptures: COL1A1 gene variant. Br J Sports Med, 43(5), 352–356.
  • Stepien-Slodkowska, M., Ficek, K., Eider, J., et al. (2013). The 1245 G/T polymorphisms in the collagen type I alpha 1 (col1a1) gene in polish skiers with anterior cruciate ligament injury. Biol Sport, 30(1), 57–60.
  • Ulucan, K., Yalcin, S., Akbas, B., Uyumaz, F., Konuk, M. (2014). Analysis of Solute Carrier Family 6 Member 4 Gene promoter polymorphism in young Turkish basketball players. The journal of Neurobehavioral Sciences, 1(2), 37-40.
  • Ulucan, K. (2016). Literature Review of Turkish Sportsmen in Terms of ACTN3 R577X Polymorphism. Clinical and Experimental Health Sciences, 6(1), 44-47.
  • Wang, C., Li, H., Chen, K., Wu, B., Liu, H. (2017). Association of polymorphisms rs1800012 in COL1A1 with sports-related tendon and ligament injuries: a meta-analysis. Oncotarget, 8, 27627–27634.

Ayrıntılar

Birincil Dil İngilizce
Konular Spor Bilimleri
Bölüm SPORT AND HEALTH
Yazarlar

Beste TACAL ASLAN> (Sorumlu Yazar)
FACULTY OF DENTISTRY
0000-0001-5271-7917
Türkiye


Başak FUNDA EKEN Bu kişi benim
FACULTY OF DENTISTRY
Türkiye


Tugba KAMAN>
USKUDAR UNIVERSITY
Türkiye


Canan SERCAN Bu kişi benim
USKUDAR UNIVERSITY
0000-0002-2218-2234
Türkiye


Korkut ULUCAN>
FACULTY OF DENTISTRY
0000-0002-1304-9386
Türkiye

Yayımlanma Tarihi 29 Mayıs 2020
Kabul Tarihi 11 Mayıs 2020
Yayınlandığı Sayı Yıl 2020, Cilt 11, Sayı 2

Kaynak Göster

Bibtex @araştırma makalesi { psbd625847, journal = {Pamukkale Journal of Sport Sciences}, eissn = {1309-0356}, address = {}, publisher = {Pamukkale Üniversitesi}, year = {2020}, volume = {11}, number = {2}, pages = {1 - 4}, title = {Collagen type I alpha 1 (COL1A1) rs1800012 polymorphism in cyclists}, key = {cite}, author = {Tacal Aslan, Beste and Funda Eken, Başak and Kaman, Tugba and Sercan, Canan and Ulucan, Korkut} }
APA Tacal Aslan, B. , Funda Eken, B. , Kaman, T. , Sercan, C. & Ulucan, K. (2020). Collagen type I alpha 1 (COL1A1) rs1800012 polymorphism in cyclists . Pamukkale Journal of Sport Sciences , 11 (2) , 1-4 . Retrieved from https://dergipark.org.tr/tr/pub/psbd/issue/54774/625847
MLA Tacal Aslan, B. , Funda Eken, B. , Kaman, T. , Sercan, C. , Ulucan, K. "Collagen type I alpha 1 (COL1A1) rs1800012 polymorphism in cyclists" . Pamukkale Journal of Sport Sciences 11 (2020 ): 1-4 <https://dergipark.org.tr/tr/pub/psbd/issue/54774/625847>
Chicago Tacal Aslan, B. , Funda Eken, B. , Kaman, T. , Sercan, C. , Ulucan, K. "Collagen type I alpha 1 (COL1A1) rs1800012 polymorphism in cyclists". Pamukkale Journal of Sport Sciences 11 (2020 ): 1-4
RIS TY - JOUR T1 - Collagen type I alpha 1 (COL1A1) rs1800012 polymorphism in cyclists AU - BesteTacal Aslan, BaşakFunda Eken, TugbaKaman, CananSercan, KorkutUlucan Y1 - 2020 PY - 2020 N1 - DO - T2 - Pamukkale Journal of Sport Sciences JF - Journal JO - JOR SP - 1 EP - 4 VL - 11 IS - 2 SN - -1309-0356 M3 - UR - Y2 - 2020 ER -
EndNote %0 Pamukkale Spor Bilimleri Dergisi Collagen type I alpha 1 (COL1A1) rs1800012 polymorphism in cyclists %A Beste Tacal Aslan , Başak Funda Eken , Tugba Kaman , Canan Sercan , Korkut Ulucan %T Collagen type I alpha 1 (COL1A1) rs1800012 polymorphism in cyclists %D 2020 %J Pamukkale Journal of Sport Sciences %P -1309-0356 %V 11 %N 2 %R %U
ISNAD Tacal Aslan, Beste , Funda Eken, Başak , Kaman, Tugba , Sercan, Canan , Ulucan, Korkut . "Collagen type I alpha 1 (COL1A1) rs1800012 polymorphism in cyclists". Pamukkale Journal of Sport Sciences 11 / 2 (Mayıs 2020): 1-4 .
AMA Tacal Aslan B. , Funda Eken B. , Kaman T. , Sercan C. , Ulucan K. Collagen type I alpha 1 (COL1A1) rs1800012 polymorphism in cyclists. Pamukkale Journal of Sport Sciences. 2020; 11(2): 1-4.
Vancouver Tacal Aslan B. , Funda Eken B. , Kaman T. , Sercan C. , Ulucan K. Collagen type I alpha 1 (COL1A1) rs1800012 polymorphism in cyclists. Pamukkale Journal of Sport Sciences. 2020; 11(2): 1-4.
IEEE B. Tacal Aslan , B. Funda Eken , T. Kaman , C. Sercan ve K. Ulucan , "Collagen type I alpha 1 (COL1A1) rs1800012 polymorphism in cyclists", Pamukkale Journal of Sport Sciences, c. 11, sayı. 2, ss. 1-4, May. 2020