Effect of Lacidipine on Cytotoxic, Inflammatory, and Oxidative Parameters in SW480 Colon Cancer Cell Line

Özge Balpınar; Muhammed Sait Ertuğrul

doi:10.62425/rtpharma.1755193

Effect of Lacidipine on Cytotoxic, Inflammatory, and Oxidative Parameters in SW480 Colon Cancer Cell Line

Abstract

Objective: This study aimed to evaluate the antiproliferative effects of lacidipine, a dihydropyridine-derived L-type calcium channel blocker, on the human colon cancer cell line (SW480) and the associated changes in inflammatory and oxidative stress markers. Materials and Methods: SW480 cells were exposed to lacidipine doses ranging from 100 to 250 µg/mL. Cytotoxicity was assessed using the MTT assay. Oxidative stress levels were measured using TAC and TOS parameters, while the inflammatory response was assessed using ELISA for IL-1β, TNF-α, and TGF-β levels. Results: Lacidipine exhibited significant cytotoxic effects at a dose of 100 µg/mL, but increased cell viability was observed at higher doses. No statistically significant changes were observed in TAC and TOS levels. However, a significant decrease in IL-1β, TNF-α, and TGF-β levels was detected due to lacidipine; the most effective dose was determined to be 150 µg/mL. Conclusion: Lacidipine may have an antiproliferative effect by reducing inflammatory cytokine levels in SW480 colon cancer cells. These findings support the potential anticancer effect of lacidipine related to its anti-inflammatory properties, and further preclinical studies are needed to elucidate its mechanisms.

Keywords

References

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Details

Primary Language

English

Subjects

Basic Pharmacology

Journal Section

Research Article

Authors

Özge Balpınar
0000-0003-4235-9241
Türkiye

Muhammed Sait Ertuğrul ^*
0000-0002-7885-5645
Türkiye

Publication Date

August 31, 2025

Submission Date

August 1, 2025

Acceptance Date

August 16, 2025

Published in Issue

Year 2025 Volume: 3 Number: 2

DOI

https://doi.org/10.62425/rtpharma.1755193

IZ

https://izlik.org/JA98JJ88JM

Cite

RIS / Bibtex

APA

Balpınar, Ö., & Ertuğrul, M. S. (2025). Effect of Lacidipine on Cytotoxic, Inflammatory, and Oxidative Parameters in SW480 Colon Cancer Cell Line. Recent Trends in Pharmacology, 3(2), 70-74. https://doi.org/10.62425/rtpharma.1755193

AMA

1.Balpınar Ö, Ertuğrul MS. Effect of Lacidipine on Cytotoxic, Inflammatory, and Oxidative Parameters in SW480 Colon Cancer Cell Line. Recent Trends in Pharmacology. 2025;3(2):70-74. doi:10.62425/rtpharma.1755193

Chicago

Balpınar, Özge, and Muhammed Sait Ertuğrul. 2025. “Effect of Lacidipine on Cytotoxic, Inflammatory, and Oxidative Parameters in SW480 Colon Cancer Cell Line”. Recent Trends in Pharmacology 3 (2): 70-74. https://doi.org/10.62425/rtpharma.1755193.

EndNote

Balpınar Ö, Ertuğrul MS (August 1, 2025) Effect of Lacidipine on Cytotoxic, Inflammatory, and Oxidative Parameters in SW480 Colon Cancer Cell Line. Recent Trends in Pharmacology 3 2 70–74.

IEEE

[1]Ö. Balpınar and M. S. Ertuğrul, “Effect of Lacidipine on Cytotoxic, Inflammatory, and Oxidative Parameters in SW480 Colon Cancer Cell Line”, Recent Trends in Pharmacology, vol. 3, no. 2, pp. 70–74, Aug. 2025, doi: 10.62425/rtpharma.1755193.

ISNAD

Balpınar, Özge - Ertuğrul, Muhammed Sait. “Effect of Lacidipine on Cytotoxic, Inflammatory, and Oxidative Parameters in SW480 Colon Cancer Cell Line”. Recent Trends in Pharmacology 3/2 (August 1, 2025): 70-74. https://doi.org/10.62425/rtpharma.1755193.

JAMA

1.Balpınar Ö, Ertuğrul MS. Effect of Lacidipine on Cytotoxic, Inflammatory, and Oxidative Parameters in SW480 Colon Cancer Cell Line. Recent Trends in Pharmacology. 2025;3:70–74.

MLA

Balpınar, Özge, and Muhammed Sait Ertuğrul. “Effect of Lacidipine on Cytotoxic, Inflammatory, and Oxidative Parameters in SW480 Colon Cancer Cell Line”. Recent Trends in Pharmacology, vol. 3, no. 2, Aug. 2025, pp. 70-74, doi:10.62425/rtpharma.1755193.

Vancouver

1.Özge Balpınar, Muhammed Sait Ertuğrul. Effect of Lacidipine on Cytotoxic, Inflammatory, and Oxidative Parameters in SW480 Colon Cancer Cell Line. Recent Trends in Pharmacology. 2025 Aug. 1;3(2):70-4. doi:10.62425/rtpharma.1755193