NÖTROFİL/LENFOSİT ORANI PREDİYABETİK HASTALARDA İNSÜLİN DİRENCİ TAHMİNİNDE HOMA-IR İNDEKSİNE ALTERNATİF BİR BELİRTEÇ OLABİLİR Mİ?: BİR RETROSPEKTİF ÇALIŞMA

Abstract

Amaç: Çalışmamızda prediyabet ve diyabet olmayan hastalarda HOMA-IR indeksi ile Trigliserid/Glukoz (TyG) indeksi, LDL-K/HDL-K oranını, Trigliserid/ HDL-K oranını ve Nötrofil/ Lenfosit Oranını (NLO) bir biri ile karşılaştırmayı amaçladık. Gereç ve Yöntem: Çalışmamıza Niğde Ömer Halisdemir Üniversitesi Eğitim ve Araştırma Hastanesine 2019-2021 yılları arasında başvuran 18-75 yaş arasında 673’ü kadın 890’ü erkeklerden oluşan toplam 1433 hasta dahil edilmiştir. HOMA-IR indeksi, TyG indeksi, LDL-K/HDL-K oranı, Trigliserid/ HDL-K oranı, NLO hesaplamaları analizi yapılan testler vasıtasıyla yapılmıştır. Bulgular: Bulgularımıza göre diyabetik olmayan grupta Trigliserid/HDL-K oranının ve pre-diyabetik grupta NLO’nun rutinde kullanılan yöntem olan HOMA-IR indeksine göre hem de IR tahmininde kullanılan diğer indekslere göre duyarlılığı ve özgüllüğünün daha yüksek olduğu tespit edildi. Ayrıca diyabetik olmayan grupta Trigliserid/HDL-K oranı ile HOMA-IR indeksi arasında pozitif anlamlı bir korelasyon sonucuna ulaşılırken (r=0,219; p<0,001), pre-diyabetik grupta NLO ile HOMA-IR indeksi arasında anlamlı bir korelasyon sonucu bulunamadı (r=0,034; p=0,290). Sonuç: Sonuç olarak, NLO pre-diyabetik hastalarda IR tahmininde HOMAIR yerine alternatif bir parametre olabilir. Ancak bunun referans yöntem ile verifikasyonu yapılan prospektif çalışmalar ile doğrulanması gerektiği düşüncesindeyiz.

Keywords

• Trigliserid/HDL-K oranı
• TyG indeksi
• HOMA-IR oranı
• LDL-K/HDL-K oranı
• NLO insülin resistansı
• metabolik sendrom

COULD THE NEUTROPHIL/LYMPHOCYTE RATIO BE AN ALTERNATIVE MARKER FOR THE PREDICTION OF INSULIN RESISTANCE IN PREDIABETIC PATIENTS?: A RETROSPECTIVE STUDY

Abstract

Objective: In our study, we aimed to compare Triglyceride/Glucose (TyG) index, LDL-C/HDL-C ratio, Triglyceride/HDL-C ratio, and Neutrophil/ Lymphocyte Ratio (NLR) with the HOMA-IR index in non-diabetes and prediabetes. Material and methods: A total of 1433 patients were included 673 women, and 890 men, aged between 18-75 years, applied to Niğde Ömer Halisdemir University Training and Research Hospital between 2019-2021 in our study. HOMA-IR index, TyG index, LDL-C/HDL-C ratio, Triglyceride/ HDL-C ratio, and NLO values were calculated by means of the analyzed tests. Results: According to our findings, the sensitivity and specificity of the Triglyceride/HDL-C ratio in the non-diabetic group and the NLR in the prediabetic group were higher than the routinely used method, the HOMA-IR index, as well as other indexes used in IR estimation. In addition, while a positive significant correlation was found between the Triglyceride/HDL-C ratio and the HOMA-IR index in the non-diabetic group (r=0.219; p<0.001), there was no significant correlation between NLR and HOMA-IR index in the pre-diabetic group (r=0.219; p<0.001), r=0.034; p=0.290). Conclusion: NLR may be an alternative parameter to predict IR in prediabetic patients. However, we think that there is a need for prospective studies that are verified by the reference method.

Keywords

• Triglyceride/HDL-C ratio
• TyG index
• HOMA-IR ratio
• LDL-C/HDL-C ratio
• NLO insulin resistance
• metabolic syndrome

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