C-ERB B2 EXPRESSION IN COLORECTAL CARCINOMA; ITS RELATIONSHIP WITH TUMOR GRADE AND OTHER PROGNOSTIC FACTORS

Yıl 2024, , 81 - 86, 04.06.2024

Neslihan Şengül Şimşek , Mehmet Yaldız

https://doi.org/10.26650/JARHS2024-1366466

Öz

Objective: The multidisciplinary management of colorectal carcinoma (CRC) is based on tumor stage, grade, and presence of vascular invasion. In this approach, information derived from the molecular characteristics of the tumor may be missed. There is a need to determine new prognostic parameters.

Human epidermal growth factor 2 (c-erb B2) protein overexpression is implicated in the development of various tumor types, while the data on CRC is ambiguous. This study aimed at determining the frequency of c-erb B2 overexpression in CRC, checking it against prognostic parameters, as it has a special role in breast and gastric cancers.

Material and Methods: A total of 71 colectomy specimens diagnosed as CRC at the Mustafa Kemal University Medical Faculty, Department of Pathology between January 2007, and December 2012, were included in this study. The c-erb B2 overexpression of tumor cells was detected by using immunohistochemistry (IHC).

Results: Among the 71 CRC cases, 34 (47.9%) of them were c-erb B2 score 0, 22 (31%) of them were score 1, 10 (14.1%) of them were score 2, 5 (7%) of them were score 3.

Conclusion: The overexpression of c-erb B2 protein was detected in 21.1% of CRC cases whereas no significant relationship with prognostic parameters was determined

Anahtar Kelimeler

ERBB-2 protein, colorectal neoplasms, prognosis

Proje Numarası

11421

KOLOREKTAL KARSİNOMLARDA C-ERB B2 EKSPRESYONUNUN TÜMÖR DERECESİ VE DİĞER PROGNOSTİK FAKTÖRLERLE İLİŞKİSİ

Öz

Amaç: Kolorektal karsinomlarda multidisipliner yaklaşımda tümör evresi ve derecesi ile vasküler invazyon varlığı esas alınmaktadır. Bu yaklaşımda tümörün moleküler karakteristik bilgileri atlanabilmektedir. Bu tümörler için yeni prognostik parametrelerin belirlenmesine ihtiyaç duyulmaktadır. Birçok tümör tipinin gelişiminde c-erb B2 proteini aşırı ekspresyonu gösterilmiştir, ancak kolorektal karsinomlarda bu konudaki sonuçlar net değildir. Bu çalışmada meme ve mide kanserinde özel bir rolü olan insan kaynaklı epidermal büyüme faktörü 2 (c-erb B2) proteini aşırı ekspresyonunun kolorektal karsinomlardaki frekansını belirlemek ve prognostik parametrelerle ilişkisini araştırmak hedeflenmiştir.

Gereç ve Yöntemler: Ocak 2007 ile Aralık 2012 tarihleri arasında Mustafa Kemal Üniversitesi Tıp Fakültesi Patoloji Bölümü’nde kolorektal karsinom tanısı alan 71 kolektomi örneği bu çalışmaya dahil edilmiştir. Tümör hücrelerinin c-erb B2 protein ekspresyonu, immünohistokimyasal yöntemle araştırılmıştır.

Bulgular: Yetmiş bir kolorektal karsinom olgusundan 34 (%47,9) tanesi c-erb B2 skor 0, 22 (%31) tanesi skor 1, 10 (%14,1) tanesi skor 2, 5 (%7) tanesi skor 3olarak değerlendirilmiştir.

Sonuç: Kolorektal karsinom olgularının %21,1’inde c-erb B2 proteini aşırı ekspresyonu tespit edilmiştir; ancak prognostik parametrelerle anlamlı bir ilişkisi izlenmemiştir.

Anahtar Kelimeler

ERBB-2 proteini, kolorektal neoplazmlar, prognoz

Etik Beyan

Hatay Mustafa Kemal Üniversitesi Etik Kurul onayı alınmıştır (4.10.2012 no:24-2012/59)

Destekleyen Kurum

Hatay Mustafa Kemal Üniversitesi Bilimsel Araştırma Projeleri Koordinatörlüğü

Proje Numarası

11421

Kaynakça

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