METABOLİK SENDROMDA ADAMTS’LERİN BİYOKİMYASAL PARAMETRELER İLE İLİŞKİSİ

Abstract

Amaç: Çalışmamızda ateroskleroz gelişimine bağlı olarak damarlardaki ekstraselüler matriksin bozulmasının neticesinde düzeylerinde değişiklik olabileceği düşünülen a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) proteinlerinin metabolik sendromlu ve diyabetli bireylerde biyokimyasal belirteç olarak kullanılma potansiyellerini ortaya koymaktır. Gereç ve Yöntemler: Çalışmamız, 25-65 yaş aralığında deney grubunda diyabet tanısı konulmuş 10 kadın birey, metabolik sendrom tanısı konulmuş 10 kadın birey ve sağlıklı 11 kadın bireyin katılımıyla gerçekleştirilmiştir. Çalışmadaki bireylerin biyokimyasal analizleri ve antropometrik ölçümleri yapılıp kan örnekleri alındı. Alınan kan örneklerinden serumları ayrıldı. ADAMTS-1 ve ADAMTS-9 serum düzeyleri ELISA yöntemiyle analiz edildi. Bulgular: ADAMTS-1 protein miktarı incelendiğinde deney ve kontrol grupları karşılaştırıldığında ADAMTS-1 düzeyi istatistiksel olarak (p<0,01) anlamlı derece düşük bulunmuştur. ADAMTS-9 protein miktarı incelendiğinde ise gruplar arasında yine benzer şekilde istatistiksel olarak anlamlı (p<0,01) azalmalar tespit edilmiştir. Sonuç: ADAMTS-1 ve ADAMTS-9 proteinlerinin metabolik sendromda erken teşhis ve tedavi sürecinde ve hastalığın patogenezinde kullanılma potansiyellerinin mevcut olduğunu gösteren bir ön çalışma niteliğindedir. Fakat bu potansiyelin detaylı olarak araştırılması gerekmektedir.

Keywords

• ADAMTS-1
• ADAMTS-9
• diabetes mellitus
• metabolik sendrom
• ateroskleroz

RELATIONSHIP OF ADAMTS WITH BIOCHEMICAL PARAMETERS IN METABOLIC SYNDROME

Abstract

Objective: The aim of our study was to investigate the potential of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) proteins, which are thought to change in levels as a result of the deterioration of the extracellular matrix in the vessels due to the development of atherosclerosis, to be used as biochemical markers in individuals with metabolic syndrome and diabetes. Material and Methods: Our study was carried out with the participation of 10 female individuals diagnosed with diabetes in the experimental group, 10 female individuals diagnosed with metabolic syndrome and 11 healthy female individuals the aged 25-65 years. Biochemical analyses and anthropometric measurements were performed and blood samples were taken. Serum was separated from the blood samples. ADAMTS-1 and ADAMTS-9 serum levels were analysed using ELISA method. Results: When the amount of ADAMTS-1 protein was analysed, ADAMTS-1 level was found to be statistically (p<0.01) significantly lower when the experimental and control groups were compared. When the amount of ADAMTS-9 protein was analysed, similarly statistically significant (p<0.01) decreases were found between the groups. Conclusion: This is a preliminary study showing that ADAMTS-1 and ADAMTS-9 proteins can be used in the early diagnosis and treatment of metabolic syndrome and in the pathogenesis of the disease. However, this potential needs to be investigated in detail.

Keywords

• ADAMTS-1
• ADAMTS-9
• diabetes mellitus
• metabolic syndrome
• atherosclerosis

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