Current Therapeutic Approaches to Medication-Related Osteonecrosis of the Jaw

Abstract

Medication-related osteonecrosis of the jaw is a relatively new health problem, which has been affecting an increasing number of cancer and osteoporosis patients each day. Treatment alternatives for this pathology range from conservative therapies to varied surgical interventions. Other treatment alternatives, such as lasers, platelet concentrates, hyperbaric oxygen, ozone therapy, teriparatide, pentoxifylline and alpha-tocopherol, may also be utilized as adjunctive therapies. The generally accepted treatment approach is the palliation of symptoms and controlling associated infection. Because there is a lack of consensus on the ideal treatment approach, many individual factors are considered in the decision-making proccess and the choice of treatment is based on the clinician’s expertise rather than the evidence-based dentistry. In this article, current approaches to the treatment of medication-raleted osteonecrosis of the jaw and their outcomes are discussed in view of available literature

Keywords

• Medication-related osteonecrosis of the jaw,bisphosphonates,conservative treatment,surgical treatment,adjunctive therapies

İlaca Bağlı Çene Kemiği Osteonekrozlarında Güncel Tedavi Yaklaşımları

Abstract

İlaca bağlı çene kemiği osteonekrozları nispeten güncel sağlık sorunları olup her geçen gün daha fazla kanser ve osteoporoz hastasını etkilemektedir. Bu alanda mevcut tedavi seçenekleri, konservatif tedavi ve farklı cerrahi uygulamaları kapsamakla birlikte, lazer, trombositten zengin ürünlerin kullanımı, hiperbarik oksijen, ozon tedavisi, parathormon, pentoksifilin ve alfa-tocopherol kullanımı gibi alternatif tedavi yöntemleri destek amaçlı uygulanmaktadır. Tedavide semptomların hafifletilmesi ve enfeksiyon bulgularının giderilmesi yönünde yaklaşım benimsenmektedir. Tedavi yöntemi üzerinde ortak görüş bulunmamakta, karar verme sürecinde hastaya özgü faktörler değerlendirilmekte ve hekimin klinik tecrübesine göre kanıta dayalı olmayan tedavi yaklaşımları tercih edilmektedir. Bu makalede ilaç kullanımlarına bağlı çene osteonekrozlarının tedavilerine yönelik güncel yaklaşımlar ve sonuçları literatür bilgileri eşliğinde tartışılacaktır.

Keywords

• İlaca bağlı çene kemiği osteonekrozu, bifosfonatlar, konservatif tedavi, cerrahi tedavi, destek tedavi

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