Dental Management in Medication-Related Osteonecrosis of the Jaws and Current Treatment Approachs: Review

Abstract

Today, antiresorptive and antiangiogenic drugs are used in the treatment of breast, prostate or lung cancer, hypercalcemia, multiple myeloma or osteolytic metastatic lesions. In addition to these diseases, they can also be used in the treatment of osteoporosis. Depending on the use of these drugs, osteonecrosis may occur in the maxilla and mandible. In this review, we aimed to provide information about the etiology, risk factors, clinical course, radiological features, current treatment protocols and dental approach of the osteonecrosis that develops due to drug use in the jaws

Keywords

• Medication-Related Osteonecrosis of the Jaws
• antiresorptive and antiangiogenic drugs
• dental treatment approaches

İlaca Bağlı Olarak Çene Kemiklerinde Görülen Osteonekrozda Dental Yönetim ve Güncel Tedavi Yaklaşımları: Derleme

Abstract

Günümüzde meme, prostat veya akciğer kanseri, hiperkalsemi, multipl myelom veya osteolitik yapıdaki metastatik lezyonların tedavisinde antirezorptif ve antianjiyojenik ilaçlar kullanılmaktadır. Bu hastalıklara ek olarak osteoporoz tedavisinde de kullanılabilmektedirler. Bu ilaçların kullanımına bağlı olarak, maksilla ve mandibulada osteonekroz oluşabilmektedir. Bu derlemede; çenelerde ilaç kullanımına bağlı olarak gelişen osteonekrozların etiyolojisi, risk faktörleri, klinik seyri, radyolojik özellikleri, güncel tedavi protokolleri ve ayrıca diş hekimi yaklaşımı hakkında bilgi vermeyi amaçladık.

Keywords

• İlaca bağlı gelişen çene kemiği osteonekrozu
• antirezorptif ve antianjiyojenik ilaçlar
• dental tedavi yaklaşımları

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