A Review On Current Perspective Of Gastroretentive Drug Delivery Systems Prioritising Floating Dosage Forms

Abstract

Current pharmaceutical approaches continue to favour oral dosage delivery systems above all other routes. This is due to ease of administration and increase in patient complaisance. A common objective of a drug delivery systems is to achieve a drug that could be taken in a single dosage form. Yet, drug delivery mechanisms generally lack certain characteristics such as an adequate oral bioavailability and a prolonged half-life. Floating drug delivery systems (FDDS) are systems that are a part of gastroretentive drug delivery systems (GRDDS) with low density that has floating ability over the gastric contents of the stomach. Floating dosage forms are taken orally and developed to increase the transit time of the active substance through the gastrointestinal tract and to achieve a systemic effect. The taken drug will remain at floating state in the stomach for an extended period without affecting the gastric emptying rate. FDDS provides an efficient method for improving the drug’s bioavailability, reducing drug waste and providing controlled drug delivery systems. This review will generally focus on FDDS as a GRDDS and classify alternative systems, such as non-floating systems, and briefly mention excipients used in order to obtain an effective gastroretentive system.

Keywords

• Floating Drug Delivery Systems (FDDS)
• Gastroretentive Drug Delivery Systems (GRDDS)
• Gastric Content
• Non-Floating Drug Delivery Systems
• Effervescent Systems
• Non-effervescent Systems

Güncel Bakış Açısı ile Yüzen Dozaj Formlarına Öncelik Vererek Gastroretentif İlaç Salım Sistemlerinin Derlemesi

Abstract

Mevcut farmasötik yaklaşımlarda, diğer tüm yollarından farklı olarak halen oral dozaj formları tercih edilmeye devam etmektedir. Bunun nedeni uygulama kolaylığı ve hasta uyuncunun yüksek olmasıdır. İlaç salım sistemlerinin ortak amacı, ilacın tek bir dozaj formu olarak alınabilmesini sağlamaktır. Yine de, ilaç salım mekanizmaları genellikle uygun bir biyoyararlanım ve uzatılmış yarı ömür gibi özelliklerden yoksundur. Yüzebilen ilaç salım sistemleri (FDDS), mide içeriği üzerinde kalabilme özelliğine sahip, düşük yoğunluklu olan sistemlerdir ve gastroretentif ilaç salım sistemlerinin (GRDDS) bir parçası olarak değerlendirilirler. Yüzebilen dozaj formları ağızdan alınır ve etken maddenin gastrointestinal sistemden geçiş süresini uzatarak lokal/sistemik etki elde etmek için geliştirilirler. Söz konusu ilaç mide boşalma hızını etkilemeden uzun süre midede yüzer halde kalır. FDDS ilaç biyoyararlanımını iyileştirir, ilaç israfını azaltır ve kontrollü ilaç salım sistemi etkisini sağlamak için etkili bir yöntem olarak değerlendirilir. Bu derleme, genellikle bir gastoretentif ilaç sistemlerinden birisi olan yüzebilen dozaj formlarına odaklanmıştır ve özetle gastrik sistemde kalabilen alternatif sistemlerden ve bu sistemleri geliştirmek için kullanılan eksipiyanlardan bahsedecektir.

Keywords

• Yüzebilen İlaç Salım Sistemleri (FDDS)
• Gastroretentif İlaç Salım Sistemleri (GRDDS)
• Gastrik İçerik
• Yüzmeyen İlaç Salım Sistemleri
• Efervesan Sistemler
• Efervesan Olmayan Sistemler

Supporting Institution

İstanbul Üniversitesi

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