COVID-19 and Hemophagocytic Lymphohistiocytosis

Yıl 2020, Cilt: 3 Sayı: S1, 49 - 52, 15.05.2020

Ömer Devecioğlu

Öz

COVID-19 disease ,which has been seen first, in City Wuhan of Hubei Province of China ,with it’s etiology,contamination route and treatment options continues to being the main topic of the World. Because of it’s severe form ,necessitating intensive care facilities, COVID-19 disease is the main subject of different investigations. During the course of COVID-19 infection, symptoms of macrophage activation syndrome/secondary Hemophagocytic Lymphohistiotosis (MAS/sHLH) may develop, characterized by cytokin storm due to excessive inflammatory response. In this article the relation of COVID-19 diasease with Hemophagocytic Lymphohistiocytosis is discussed.

Anahtar Kelimeler

COVID-19, HLH, Cytokine storm

COVID-19 ve Hemofagositik Lenfohistiyositoz

Öz

Ocak 2020 başından beri önce Çin’in Hubei Eyaleti Wuhan Kentinde ortaya çıkan ve COVID-19 diye adlandırılan hastalık, nedeni, bulaşma şekli ve tedavi seçenekleri ile dünya kamuoyunu yoğun bir şekilde meşgul etmektedir.Yüzde 20 oranında ciddi seyreden hastalıkta, mortalite %2-3 civarındadır. Ancak bu hastalık son döneminde yoğun bakım şartları gerektiren ağır formu nedeniyle yoğun araştırma konusudur. COVID-19 enfeksiyonun seyri sırasında aşırı enflamatuvar yanıta bağlı sitokin fırtınası ile karakterize makrofaj aktivasyonu sendromu/sekonder Hemofagositik Lenfohistiyotoz (MAS/sHLH) bulguları gelişebilir. Bu makalede COVID-19 hastalığının HLH ile olan ilişkisi derlenmiştir

Anahtar Kelimeler

COVID-19, HLH, Sitokin fırtınası

Kaynakça

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