Objective: This study investigated the cumulative antimicrobial data of bacteria isolated from blood cultures and aimed to contributing to clinicians' empirical treatment selection. Material and Methods: The study included blood cultures studied between January 2018 and May 2019. Only bacteria species that have 30 or more isolates were evaluated. Only the first isolate for each patient was included in the study. The cumulative antibiotic susceptibility limit for empirical treatment was >90%. Results: The most appropriate antibiotics for empirical treatment in methicillin-resistant Staphylococcus aureus isolates were vancomycin, teicoplanin and linezolid. Co-trimoxazole and tetracycline options in addition to vancomycin, teicoplanin and linezolid were suitable for therapy in methicillin-sensitive S. aureus isolates. Ampicillin and high level-gentamicin alongside vancomycin, teicoplanin and linezolid were found to be appropriate for empirical treatment in Enterococcus faecalis isolates, while linezolid was the only option in Enterococcus faecium isolates. Although cephalosporins, aminoglycosides and piperacillin tazobactam as well as carbapenems were suitable for empiric therapy in the ESBL-negative group, only carbapenems were found suitable for empirical treatment in Escherichia coli isolates producing extended-spectrum betalactamase. There was no empirical treatment option for ESBL positive Klebsiella pneumoniae. Carbapenem resistance of these bacteria was found to reach 50%. Third and 4th generation cephalosporins, carbapenems, aminoglycosides and ciprofloxacin were appropriate for empirical treatment in ESBL negative K. pneumoniae isolates. Conclusion: Due to the high resistance rates in our study, regular surveillance monitoring should be performed. Studies are needed to test the efficacy of antibiotic combinations for multi-resistant organisms, including carbapenem-resistant bacteria.
|Teşekkür||Mikrobiyoloji alanında yetişmemde büyük emeği geçen sayın Prof. Dr. Nezahat GÜRLER’e, verilerin bir kısmının derlenmesinde destek veren Yüksek Lisans öğrencisi Rama Al Hamwi’ye ve tüm laboratuvar çalışanlarımıza teşekkür ederiz.|
: 5 Mayıs 2020
|APA||Öksüz, L , Aktaş, Z . (2020). Bir Üniversite Hastanesinde Kan Kültürlerinden İzole Edilen Bakterilerin Kümülatif Antibiyogram Sonuçları . Sağlık Bilimlerinde İleri Araştırmalar Dergisi , 3 (2) , 35-44 . Retrieved from https://dergipark.org.tr/tr/pub/sabiad/issue/55974/732729|