Mitochondrial DNA, Maternal Inheritance and Human

Yıl 2021, Cilt: 4 Sayı: 2, 65 - 74, 21.06.2021

Can Veysel Şoroğlu Ezgi Gizem Berkay Burçak Vural

Öz

Mitochondrial DNA (mtDNA) studies have been formed within the network of medicine, genetics, anthropology, and archeology. It has been an indispensable source of knowledge in relation to population relationships, migration routes, evolutionary developmental steps, and enlightening historical unknowns over the ages as well as being essential in researching maternally inherited mitochondrial diseases. mtDNA - haplogroup studies provide us advanced data with molecular genetic techniques and the development of next-generation sequencing technologies, which cannot be obtained with the classical approach of anthropological studies. In this review, mtDNA studies obtained from ancient and modern human materials were reviewed.

Anahtar Kelimeler

mtDNA, Haplogroup, Archaeogenetics

Mitokondriyal DNA, Anaerkil Kalıtım ve İnsan

Öz

Mitokondriyal DNA (mtDNA) çalışmaları tıp, genetik, antropoloji ve arkeoloji birlikteliği ile şekillenmektedir. Çağlar boyunca değişen akrabalık ilişkileri, göç yollarının tespiti, çeşitli nedenlerle yer değiştiren topluluklar, evrimsel gelişmeler, tarihi bilinmezlerin aydınlatılması ve maternal kalıtımlı mitokondriyal hastalıklar hakkında vazgeçilmez bir bilgi kaynağı olmuştur. Arkeolojik kazılardan elde edilen insan kalıntıları ile yapılan mtDNA – haplogrup çalışmaları, moleküler genetik tekniklerin ve yeni nesil dizileme teknolojilerinin gelişimi ile klasik antropolojik yaklaşımla elde edilmesi mümkün olmayan verilere ulaşmamızı sağlamaktadır. Bu derlemede antik ve modern insan materyallerinden elde edilen mtDNA çalışmaları incelenmiştir.

Anahtar Kelimeler

mtDNA, Haplogrup, Arkeogenetik

Kaynakça

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