İMMÜNOGLOBULİN A VASKÜLİTLİ TÜRK ÇOCUKLARINDA DÜŞÜK C3/ C4 DÜZEYLERİ VE DİĞER LABORATUVAR ÖZELLİKLERİYLE İLGİLİ TEK MERKEZ DENEYİMİ

Year 2025, Volume: 8 Issue: 1, 47 - 52, 04.03.2025

Şeyda Doğantan , Sema Nur Taşkın

https://doi.org/10.26650/JARHS2025-1582236

Abstract

Amaç: Eskiden Henoch-Schönlein purpurası olarak adlandırılan immünog lobulin A vasküliti (IgAV), çocukluk çağında en sık görülen sistemik vaskülit türüdür. Kompleman 3 ve 4 (C3 ve C4) kompleman sisteminin bileşenleri dir ve bazı bağışıklık hastalıklarıyla ilişkili oldukları bulunmuştur. Bu neden le bu çalışmada IgAV’li çocuklarda düşük C3/C4 düzeylerinin yanı sıra diğer laboratuvar bulgularını değerlendirmeyi amaçladık.

Gereç ve Yöntemler: Bu çalışmada 60 IgAV hastası ve 64 sağlıklı kontrol olmak üzere toplam 124 çocuk değerlendirildi. C3 ve C4 düzeyleri, üretici ayrıntılarıyla birlikte türbidimetrik immünoanaliz yöntemi kullanılarak ölçüldü. Ekstrakte edilebilir nükleer antijen antikor (ENA) panelleri, enzime bağlı immünosorbent analizleri (ELISA) kullanılarak değerlendirildi. Sonuçlar istatistiksel olarak değerlendirildi.

Bulgular: Hasta grubunda lökosit sayısı, nötrofil sayısı ve nötrofil/lenfosit oranı kontrol grubuna göre daha yüksek bulundu (sırasıyla p=0,015, p=0,013 ve p=0,039). Ayrıca hastalarda kontrollere göre CRP, ESR ve rastgele idrar protein/kreatinin oranı (RUPCR) artmış bulundu (sırasıyla p<0,001, p=0,002 ve p<0,001). Düşük C3/C4 seviyeleri ve lupus antikoagülan aktivitesi açısından gruplar arasında anlamlı fark bulunamadı (p˃0,05).

Sonuç: IgA aracılı sistemik küçük damar vasküliti olan IgAV, öncelikle böbrekleri, eklemleri, gastrointestinal sistemi ve cildi etkilemektedir. Sonuç olarak, potansiyel hasta durumlarını izlerken laboratuvar sonuçlarının değerlendirilmesi çok önemlidir.

Keywords

İmmünoglobulin A vasküliti, C3, C4, immünolojik test

A SINGLE CENTRE EXPERIENCE OF LOW C3/C4 LEVELS AND OTHER LABORATORY ASPECTS IN TURKISH CHILDREN WITH IMMUNOGLOBULIN A VASCULITIS

Abstract

Objective: Immunoglobulin A vasculitis (IgAV) is the most prevalent systemic vasculitis in childhood. This intricate immune-mediated vasculitis affects the small blood vessels in several organ systems. Complements 3 and 4 (C3 and C4) are constituents of the complement system; serum C3/ C4 measurements play a

Material and Methods: A total of 124 children—60 IgAV patients and 64 healthy controls—were assessed in this study. The C3 and C4 levels were quantified using a turbidimetric immunoassays method with manufacturer details. The extractable nuclear antigen antibody (ENA) panels were evaluated using the ELISA method. The results were evaluated statistically.

Results: The white blood cell count, neutrophil count, and neutrophil/ lymphocyte ratio were higher in the patient group compared to the control group (p=0.015, p=0.013 and p=0.039, respectively). CRP, ESR, and random urine protein/creatinine ratio (RUPCR) increased in patients than controls (p<0.001, p=0.002 and p<0.001 respectively). There was no difference in the lupus anticoagulant activity and low C3/C4 levels between the groups (p˃0.05).

Conclusion: IgAV, an IgA-mediated systemic small vessel vasculitis, affects many organs. As a result, it is crucial to evaluate the laboratory results in the follow-up of the patient and the possible complications.

Keywords

Immunoglobulin A vasculitis, C3, C4, immunoassay

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