OTOİMMÜN TİROİDİTİ OLAN HASTALARDA PREMATÜR OVARYAN YETMEZLİK SIKLIĞI

Yıl 2022, Cilt: 9 Sayı: 4, 317 - 321, 01.12.2022

Ceren YILDIZ EREN Hulusi Göktuğ GÜRER Özlem ÖZGÜR GÜRSOY Ozge GODEK

https://doi.org/10.52880/sagakaderg.1103995

Öz

Giriş ve Amaç: Premature ovaryan yetmezlik, bazı durumlarda otoimmünitenin etken olduğu, yumurtalıkların kırk yaşın altında fonksiyonlarını kaybetmesidir. Anti-Müllerian hormon, yumurtalık foliküllerinin granüloza hücreleri tarafından salgılanmaktadır. Yumurtalık rezervi AMH ölçümleri ile doğru bir şekilde değerlendirilebilir. Bu çalışmada otoimmün tiroidit tanısı alan kadınlarda Anti-Müllerian hormon düzeyine göre over rezervinin değerlendirilmesi amaçlanmıştır.
Materyal ve Metot: Bu retrospektif bir çalışmadır, Ocak 2011-Mayıs 2021 arasındaki 10 yıllık dönemi kapsamaktadır. Çalışmanın örneklemini 35 yaş altı otoimmün tiroidit nedeniyle takip ve tedavi edilen kadınlar oluşturmaktadır. Katılımcıların yumurtalık rezervleri yaşa özel AMH seviyeleri kullanılarak analiz edilmiştir. Araştırmanın yürütüldüğü sağlık merkezindeki radyoimmunoassay laboratuvarında tiroid hormon düzeyleri ölçülmüştür.
Bulgular: Bazı katılımcılarda infertilite (%66.6) yoktu. Katılımcıların 147'si (%38,7) ötiroid idi. 197 katılımcının (%51,8) yumurtalık rezervi düşük, 229 katılımcının (%60,3) yüksek anti-TPO ve 217 katılımcının (%57,2) yüksek anti-TG düzeyi vardı. Yumurtalık rezervi düşük olan katılımcılar tiroid hormon analiz sonuçları açısından gruplar arasında istatistiksel olarak anlamlı farklılık göstermektedir (p<0.05).
Sonuç: Hipotiroidili katılımcıların diğer gruplara göre daha düşük ortalama AMH ve yumurtalık rezervine sahip oldukları belirlendi.

Anahtar Kelimeler

Prematür over yetmezliği, Anti-Müllerian hormon, Otoimmün Tiroidit, Anti-TPO, Anti-TG.

Destekleyen Kurum

yok

PREVALENCE OF PREMATURE OVARIAN FAILURE IN PATIENTS WITH AUTOIMMUNE THYROIDITIS

Öz

Introduction and Aim: Premature ovarian failure is the loss of function of the ovaries under the age of forty that autoimmunity is a factor in some cases. Anti-Müllerian hormone is secreted by the granulosa cells of the ovarian follicles. Ovarian reserve can be accurately assessed with AMH measurements. This study aimed to evaluate the ovarian reserve by Anti-Müllerian hormone level in women who were diagnosed with autoimmune thyroiditis.
Methods: This is a retrospective study, covers the 10-year period between January 2011 and May 2021. Women under the age of 35 who were followed up and treated for autoimmune thyroiditis constitute the sample of the study. Participants' ovarian reserves were analyzed using age specific AMH levels. Thyroid hormone levels were measured in the radioimmunoassay laboratory in the health center where the study was conducted.
Results: Some participants did not have infertility (66.6%). 147 (38.7%) of the participants were euthyroid. 197 participants (51.8%) had a low ovarian reserve, 229 (60.3%) of the participants had high anti-TPO and 217 (57.2%) had high anti-TG levels. Participants with low ovarian reserve show a statistically significant difference between the groups in terms of thyroid hormone analysis results (p<0.05).
Conclusions: It was determined that the participants with hypothyroidism had a lower mean AMH and ovarian reserve compared to the other groups.

Anahtar Kelimeler

Premature ovarian failure, Anti-Müllerian hormone, Autoimmune Thyroiditis, Anti-TPO, Anti-TG.

Kaynakça

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