The Relationship of Vitamin D Deficiency and Obesity with Coronavirus Disease Infection

Abstract

Coronavirus disease is an important public health problem that threatens public health in many countries around the world and can result in death. Since the beginning of the pandemic, the risk factors, symptoms and supportive treatment methods of the disease have been investigated. In studies, the relationship between vitamin D deficiency and obesity and its effects on Coronavirus disease are frequently stated.
The superiority of vitamin D in strengthening the physical barrier against viruses and stopping hyper-inflammatory responses has been proven. It is an effective immunomodulatory hormone especially in upper respiratory tract infections. It has been supported by many studies that the severity of the disease and hospitalization in the intensive care unit are negatively affected in patients with Coronavirus disease accompanied by vitamin D deficiency. On the otherhand, obesity also affects morbidity and mortality in Coronavirus disease by causing various mechanical and medical problems that negatively affect general health. Obesity and vitamin D deficiency are conditions that affect each other, and the combination of both conditions plays an important role in the course of the disease.
In this review, the effects of obesity and vitamin D deficiency on the course of Coronavirus disease will be discussed. The subject will guide future Coronavirus disease treatment strategies.

Keywords

• Coronavirus disease
• vitamin D deficiency
• obesity

D Vitamini Eksikliğinin ve Obezitenin Koronavirüs Hastalığı Enfeksiyonu ile İlişkisi

Abstract

Koronavirüs hastalığı, dünyada pek çok ülkede halk sağlığını tehdit eden ve ölümle sonuçlanabilen önemli bir halk sağlığı sorunudur. Pandeminin başından itibaren hastalığın risk faktörleri, belirtileri ve destek tedavi yöntemleri araştırılmaktadır. Araştırmalarda D vitamini eksikliğinin ve obezitenin birbiri ile ilişkisi ve Koronavirüs hastalığında etkileri sıklıkla belirtilmektedir.
D vitaminin, virüslere karşı fiziksel bariyeri güçlendirme ve hiperinflamatuar yanıtları durdurmadaki üstünlüğü kanıtlanmıştır. Özellikle üst solunum yolu enfeksiyonlarında etkin bir immünomodülatör hormondur. D vitamini eksikliğinin eşlik ettiği Koronavirüs hastalığı hastalarında, hastalığın şiddetini ve yoğun bakımda yatma durumunu olumsuz etkilendiği pek çok çalışma ile desteklenmiştir. Öte yandan obezite genel sağlığı olumsuz etkileyen, çeşitli mekanik ve tıbbi sorunlara yol açarak Koronavirüs hastalığında morbidite ve mortaliteyi etkilemektedir. Obezite ve D vitamini eksikliği birbirini etkileyen bir durumdur ve her iki durumun bir arada görülmesi, enflamasyon cevabı ve hastalığın seyrinde önemli bir yere sahiptir.
Bu derlemede, obezite ve D vitamini eksikliğinin Koronavirüs hastalığının seyrindeki etkilerinden bahsedilecektir. Konu gelecekte Koronavirüs hastalığı tedavi stratejilerine rehberlik edecektir.

Keywords

• D vitamini eksikliği
• Koronavirüs hastalığı
• obezite

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