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Melatonin regulation of some important metabolic enzymes during intestinal ischemia/reperfusion injury in rats

Yıl 2008, Cilt: 1 Sayı: 2, 70 - 77, 13.08.2013

Öz

Intestinal ischemia/reperfusion (I/R) injury is known to result from both tissue hypoxia and the consequences of reperfusion of ischemic tissues. In addition, ATP stores are depleted during ischemia because of the relatively inefficient production of ATP by glycolysis. In this study, the effect of melatonin on some important metabolic enzymes hexokinase (HK), glucose-6-phosphate dehydrogenase (G6PD), lactate dehydrogenase (LDH) and malate dehydrogenase (MDH) responsible for generation of energy was investigated. Melatonin was determined to cause a distinct regulation of these enzymes. While the activity of the enzyme HK of the first step of glycolysis was significantly higher in pre-melatonin treated I/R group than group I/R animals, the activities of LDH and G6PD were decreased markedly with melatonin application. Although, the MDH levels of pre-melatonin treated I/R group were higher than the sham control group, this might not be a result of melatonin application, since both I/R and I/(Mel/R) groups also showed even higher MDH activity than the control group.

Yıl 2008, Cilt: 1 Sayı: 2, 70 - 77, 13.08.2013

Öz

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Ayrıntılar

Birincil Dil İngilizce
Bölüm Araştırma Makalesi
Yazarlar

H. Ramazan Yılmaz Bu kişi benim

Burhan Ates Bu kişi benim

Eşref Yüksel Bu kişi benim

İsmet Yılmaz Bu kişi benim

Mustafa Iraz Bu kişi benim

Yayımlanma Tarihi 13 Ağustos 2013
Yayımlandığı Sayı Yıl 2008 Cilt: 1 Sayı: 2

Kaynak Göster

APA Yılmaz, H. R., Ates, B., Yüksel, E., Yılmaz, İ., vd. (2013). Melatonin regulation of some important metabolic enzymes during intestinal ischemia/reperfusion injury in rats. Cell Membranes and Free Radical Research, 1(2), 70-77.
AMA Yılmaz HR, Ates B, Yüksel E, Yılmaz İ, Iraz M. Melatonin regulation of some important metabolic enzymes during intestinal ischemia/reperfusion injury in rats. Cell Membranes and Free Radical Research. Ağustos 2013;1(2):70-77.
Chicago Yılmaz, H. Ramazan, Burhan Ates, Eşref Yüksel, İsmet Yılmaz, ve Mustafa Iraz. “Melatonin Regulation of Some Important Metabolic Enzymes During Intestinal ischemia/Reperfusion Injury in Rats”. Cell Membranes and Free Radical Research 1, sy. 2 (Ağustos 2013): 70-77.
EndNote Yılmaz HR, Ates B, Yüksel E, Yılmaz İ, Iraz M (01 Ağustos 2013) Melatonin regulation of some important metabolic enzymes during intestinal ischemia/reperfusion injury in rats. Cell Membranes and Free Radical Research 1 2 70–77.
IEEE H. R. Yılmaz, B. Ates, E. Yüksel, İ. Yılmaz, ve M. Iraz, “Melatonin regulation of some important metabolic enzymes during intestinal ischemia/reperfusion injury in rats”, Cell Membranes and Free Radical Research, c. 1, sy. 2, ss. 70–77, 2013.
ISNAD Yılmaz, H. Ramazan vd. “Melatonin Regulation of Some Important Metabolic Enzymes During Intestinal ischemia/Reperfusion Injury in Rats”. Cell Membranes and Free Radical Research 1/2 (Ağustos 2013), 70-77.
JAMA Yılmaz HR, Ates B, Yüksel E, Yılmaz İ, Iraz M. Melatonin regulation of some important metabolic enzymes during intestinal ischemia/reperfusion injury in rats. Cell Membranes and Free Radical Research. 2013;1:70–77.
MLA Yılmaz, H. Ramazan vd. “Melatonin Regulation of Some Important Metabolic Enzymes During Intestinal ischemia/Reperfusion Injury in Rats”. Cell Membranes and Free Radical Research, c. 1, sy. 2, 2013, ss. 70-77.
Vancouver Yılmaz HR, Ates B, Yüksel E, Yılmaz İ, Iraz M. Melatonin regulation of some important metabolic enzymes during intestinal ischemia/reperfusion injury in rats. Cell Membranes and Free Radical Research. 2013;1(2):70-7.