Adenosine deaminase and Guanase deaminase activities in serum of patients with rheumatoid Arthritis

Year 2012, Volume: 4 Issue: 3, 215 - 219, 14.08.2013

Suleyman Onal

Abstract

We investigated purin and primidin salvage pathways in
rheumatoid arthritis (RA). For the aim, Adenosine deaminase
(AD) and Guanosine deaminase (GD) activities in serum of
patients with di!erent manifestations of the disease (n=32) were
investigated and compared with the control group of healthy
individuals (n=52). RA cases were classified with respect to their
clinics and treatment.
The ADA activities were significantly higher (p<0.01) in
patients with RA than in control although GD activity levels were
found to be lower (p<0.01). When compared their AD and GD
levels amongst the classified RA groups, there was no di!erence
in AD levels amongst cases.
In conclusion, increased serum AD activities in patients with
RA may be dependent on and reflect the increase in phagocytic
activity of macrophages and maturation of T-lymphocytes. The
results indicated that plasma AD and GA activity can be used for
the diagnosis of RA disease to support clinical findings and as
an index for disease.

Keywords

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