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            <front>

                <journal-meta>
                                    <journal-id></journal-id>
            <journal-title-group>
                                                                                    <journal-title>Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi</journal-title>
            </journal-title-group>
                                        <issn pub-type="epub">2146-247X</issn>
                                                                                            <publisher>
                    <publisher-name>Süleyman Demirel Üniversitesi</publisher-name>
                </publisher>
                    </journal-meta>
                <article-meta>
                                        <article-id pub-id-type="doi">10.22312/sdusbed.1633360</article-id>
                                                                <article-categories>
                                            <subj-group  xml:lang="en">
                                                            <subject>Nefroloji</subject>
                                                    </subj-group>
                                            <subj-group  xml:lang="tr">
                                                            <subject>Nefroloji</subject>
                                                    </subj-group>
                                    </article-categories>
                                                                                                                                                        <title-group>
                                                                                                                        <trans-title-group xml:lang="tr">
                                    <trans-title>The Relationship Between Echocardiographic Findings, Cognitive Functions And Depression In Dialysis Patients</trans-title>
                                </trans-title-group>
                                                                                                                                                                                                <article-title>The Relationship Between Echocardiographic Findings, Cognitive Functions And Depression In Dialysis Patients</article-title>
                                                                                                    </title-group>
            
                                                    <contrib-group content-type="authors">
                                                                        <contrib contrib-type="author">
                                                                    <contrib-id contrib-id-type="orcid">
                                        https://orcid.org/0000-0001-6539-4061</contrib-id>
                                                                <name>
                                    <surname>Avcı</surname>
                                    <given-names>Muammer</given-names>
                                </name>
                                                                    <aff>Department of Nephrology, Ministry Of Health Isparta City Hospital</aff>
                                                            </contrib>
                                                    <contrib contrib-type="author">
                                                                    <contrib-id contrib-id-type="orcid">
                                        https://orcid.org/0009-0009-0310-7149</contrib-id>
                                                                <name>
                                    <surname>Güven Avci</surname>
                                    <given-names>Ela</given-names>
                                </name>
                                                                    <aff>Department of Geriatrics, Suleyman Demirel University, Medical School,</aff>
                                                            </contrib>
                                                    <contrib contrib-type="author">
                                                                    <contrib-id contrib-id-type="orcid">
                                        https://orcid.org/0000-0002-6480-4935</contrib-id>
                                                                <name>
                                    <surname>Aksoy</surname>
                                    <given-names>Fatih</given-names>
                                </name>
                                                                    <aff>Department of Cardiology, Suleyman Demirel University, Medical School</aff>
                                                            </contrib>
                                                    <contrib contrib-type="author">
                                                                    <contrib-id contrib-id-type="orcid">
                                        https://orcid.org/0000-0002-1369-3657</contrib-id>
                                                                <name>
                                    <surname>Afşar</surname>
                                    <given-names>Barış</given-names>
                                </name>
                                                                    <aff>Department of nephrology, Saint Louis Universty, School of medicine, SSM Health Saint Louis university Hospital</aff>
                                                            </contrib>
                                                                                </contrib-group>
                        
                                        <pub-date pub-type="pub" iso-8601-date="20260420">
                    <day>04</day>
                    <month>20</month>
                    <year>2026</year>
                </pub-date>
                                        <volume>17</volume>
                                        <issue>1</issue>
                                        <fpage>27</fpage>
                                        <lpage>38</lpage>
                        
                        <history>
                                    <date date-type="received" iso-8601-date="20250207">
                        <day>02</day>
                        <month>07</month>
                        <year>2025</year>
                    </date>
                                                    <date date-type="accepted" iso-8601-date="20251008">
                        <day>10</day>
                        <month>08</month>
                        <year>2025</year>
                    </date>
                            </history>
                                        <permissions>
                    <copyright-statement>Copyright © 2010, Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi</copyright-statement>
                    <copyright-year>2010</copyright-year>
                    <copyright-holder>Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi</copyright-holder>
                </permissions>
            
                                                                                                <trans-abstract xml:lang="tr">
                            <p>İntroduction: Quality of life is associated with increased morbidity and mortality. İt is mainly determined  with depression and cognitive functions. Cognitive decline is exacerbated by both microvascular and macrovascular disease due to cerebrovascular damage even in early stages of CRF. Given the close relationship between cardiovascular disease(CVD) and chronic renal failure(CRF), this study aimed to investigate the relationship between depression and cognitive dysfunction and cardiac functions. Methods: The sample included 55 patients receiving dialysis, 37 undergoing hemodialysis and 18 undergoing peritoneal dialysis. The Beck Depression Inventory(BDI),Mini-Mental State Examination(MMSE) and echocardiography were administered to participants. Results: No significant correlation was found between the MMSE score and BDI with echocardiographic parameters in the total sample. Subgroup of 37 hemodialysis patients, a weak positive correlation was observed between the BDI score. Conclusion: This study demonstrated association between depression and cardiovascular events and no correlation between cognitive function and echocardiographic parameters.</p></trans-abstract>
                                                                                                                                    <abstract><p>İntroduction: Quality of life is associated with increased morbidity and mortality. İt is mainly determined  with depression and cognitive functions. Cognitive decline is exacerbated by both microvascular and macrovascular disease due to cerebrovascular damage even in early stages of CRF. Given the close relationship between cardiovascular disease(CVD) and chronic renal failure(CRF), this study aimed to investigate the relationship between depression and cognitive dysfunction and cardiac functions. Methods: The sample included 55 patients receiving dialysis, 37 undergoing hemodialysis and 18 undergoing peritoneal dialysis. The Beck Depression Inventory(BDI),Mini-Mental State Examination(MMSE) and echocardiography were administered to participants. Results: No significant correlation was found between the MMSE score and BDI with echocardiographic parameters in the total sample. Subgroup of 37 hemodialysis patients, a weak positive correlation was observed between the BDI score. Conclusion: This study demonstrated association between depression and cardiovascular events and no correlation between cognitive function and echocardiographic parameters.</p></abstract>
                                                            
            
                                                                                        <kwd-group>
                                                    <kwd>dialysis and depression</kwd>
                                                    <kwd>  dialysis and cognitive functions</kwd>
                                                    <kwd>  dialysis and echocardiographic findings</kwd>
                                                    <kwd>  Echocardiographic findings and cognitive functions</kwd>
                                            </kwd-group>
                            
                                                <kwd-group xml:lang="tr">
                                                    <kwd>: dialysis and depression</kwd>
                                                    <kwd>  dialysis and cognitive functions</kwd>
                                                    <kwd>  dialysis and echocardiographic findings</kwd>
                                                    <kwd>  Echocardiographic findings and cognitive functions</kwd>
                                            </kwd-group>
                                                                                                                                        </article-meta>
    </front>
    <back>
                            <ref-list>
                                    <ref id="ref1">
                        <label>1</label>
                        <mixed-citation publication-type="journal">1. Kamel, R.A.E., M. Fouad, and T.M. Goda, Anxiety and depression among hemodialysis patients in Egypt. Zagazig    University Medical Journal, 2022. 28(3): p. 594-604.</mixed-citation>
                    </ref>
                                    <ref id="ref2">
                        <label>2</label>
                        <mixed-citation publication-type="journal">2. Santos, D.G.M.d., et al., Association between frailty and depression among hemodialysis patients: a cross-sectional study. Sao Paulo Medical Journal, 2022. 140(3): p. 406-411.</mixed-citation>
                    </ref>
                                    <ref id="ref3">
                        <label>3</label>
                        <mixed-citation publication-type="journal">3. Wu, Y.-H., Y.-J. Hsu, and W.-C. Tzeng, Correlation between physical activity and psychological distress in patients             receiving hemodialysis with comorbidities: A cross-sectional study. International Journal of Environmental Research and Public Health, 2022. 19(7): p. 3972.</mixed-citation>
                    </ref>
                                    <ref id="ref4">
                        <label>4</label>
                        <mixed-citation publication-type="journal">4. Matsushita, K., et al., Epidemiology and risk of cardiovascular disease in populations with chronic kidney disease.      Nature Reviews Nephrology, 2022. 18(11): p. 696-707.</mixed-citation>
                    </ref>
                                    <ref id="ref5">
                        <label>5</label>
                        <mixed-citation publication-type="journal">5. Tian, X., et al., Cognitive dysfunction and its risk factors in patients undergoing maintenance hemodialysis. Neuropsychiatric Disease and Treatment, 2022: p. 2759-2769.</mixed-citation>
                    </ref>
                                    <ref id="ref6">
                        <label>6</label>
                        <mixed-citation publication-type="journal">6. Ak, R., et al., Kronik Böbrek Hastalığında Bilişsel Fonksiyon Bozukluğu Diyaliz Modalitesinin Etkisi. The Turkish Nephrology, Dialysis and Transplantation Journal, 2015. 24(3): p. 283-293.</mixed-citation>
                    </ref>
                                    <ref id="ref7">
                        <label>7</label>
                        <mixed-citation publication-type="journal">7. Kupske, J.W., M.M. Krug, and R.d.R. Krug, Cognitive Function of Patients with Chronic Renal Insufficiency in Hemodialysis: A Systematic Review. Psicologia: Teoria e Pesquisa, 2023. 39: p. e39202.</mixed-citation>
                    </ref>
                                    <ref id="ref8">
                        <label>8</label>
                        <mixed-citation publication-type="journal">8. Ricardo, A.C., et al., Validation of the Beck Depression Inventory in US Hispanic Patients with Chronic Kidney Disease. Clinical Journal of the American Society of Nephrology, 2024: p. 10.2215.</mixed-citation>
                    </ref>
                                    <ref id="ref9">
                        <label>9</label>
                        <mixed-citation publication-type="journal">9. Hisli, N., Beck depresyon envanterinin universite ogrencileri icin gecerliligi, guvenilirligi.(A reliability and validity study of Beck Depression Inventory in a university student sample). J. Psychol., 1989. 7: p. 3-13.</mixed-citation>
                    </ref>
                                    <ref id="ref10">
                        <label>10</label>
                        <mixed-citation publication-type="journal">10. Henry, W.L., et al., Report of the American Society of Echocardiography Committee on nomenclature and standards in two-dimensional echocardiography. Circulation, 1980. 62(2): p. 212-217.</mixed-citation>
                    </ref>
                                    <ref id="ref11">
                        <label>11</label>
                        <mixed-citation publication-type="journal">11. Sahn, D.J., et al., Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. Circulation, 1978. 58(6): p. 1072-1083.</mixed-citation>
                    </ref>
                                    <ref id="ref12">
                        <label>12</label>
                        <mixed-citation publication-type="journal">12. Krittanawong C, Maitra NS, Qadeer YK, Wang Z, Fogg S, Storch EA, et al. Association of depression and cardiovascular disease. The American journal of medicine. 2023;136(9):881-95.</mixed-citation>
                    </ref>
                                    <ref id="ref13">
                        <label>13</label>
                        <mixed-citation publication-type="journal">13 .Alshelleh S, Alhawari H, Alhouri A, Abu-Hussein B, Oweis A. Level of depression and anxiety on quality of life among patients undergoing hemodialysis. International journal of general medicine. 2023:1783-95.</mixed-citation>
                    </ref>
                                    <ref id="ref14">
                        <label>14</label>
                        <mixed-citation publication-type="journal">14. Yonata A, Islamy N, Taruna A, Pura L. Factors affecting quality of life in hemodialysis patients. International Journal of General Medicine. 2022;15:7173.</mixed-citation>
                    </ref>
                                    <ref id="ref15">
                        <label>15</label>
                        <mixed-citation publication-type="journal">15. Beurel E, Toups M, Nemeroff CB. The bidirectional relationship of depression and inflammation: double trouble. Neuron. 2020;107(2):234-56.</mixed-citation>
                    </ref>
                                    <ref id="ref16">
                        <label>16</label>
                        <mixed-citation publication-type="journal">16. Lefrère A, Burtey S, Bobot S, Belzeaux R, Bobot M. Depression in chronic kidney disease: Particularities, specific mechanisms and therapeutic considerations, a narrative review. Behavioural brain research. 2025:115467.</mixed-citation>
                    </ref>
                                    <ref id="ref17">
                        <label>17</label>
                        <mixed-citation publication-type="journal">17. Vogelzangs N, Seldenrijk A, Beekman AT, van Hout HP, de Jonge P, Penninx BW. Cardiovascular disease in persons with depressive and anxiety disorders. Journal of affective disorders. 2010;125(1-3):241-8.</mixed-citation>
                    </ref>
                                    <ref id="ref18">
                        <label>18</label>
                        <mixed-citation publication-type="journal">18. Zeng J, Qiu Y, Yang C, Fan X, Zhou X, Zhang C, et al. Cardiovascular diseases and depression: A meta-analysis and Mendelian randomization analysis. Molecular psychiatry. 2025:1-13.</mixed-citation>
                    </ref>
                                    <ref id="ref19">
                        <label>19</label>
                        <mixed-citation publication-type="journal">19. Meng R, Yu C, Liu N, He M, Lv J, Guo Y, et al. Association of depression with all-cause and cardiovascular disease mortality among adults in China. JAMA network open. 2020;3(2):e1921043-e.</mixed-citation>
                    </ref>
                                    <ref id="ref20">
                        <label>20</label>
                        <mixed-citation publication-type="journal">20. Xu L, Zhai X, Shi D, Zhang Y. Depression and coronary heart disease: mechanisms, interventions, and treatments. Frontiers in Psychiatry. 2024;15:1328048.</mixed-citation>
                    </ref>
                                    <ref id="ref21">
                        <label>21</label>
                        <mixed-citation publication-type="journal">21. Vaccarino V, Bremner JD. Stress and cardiovascular disease: an update. Nature Reviews Cardiology. 2024;21(9):603-16.</mixed-citation>
                    </ref>
                                    <ref id="ref22">
                        <label>22</label>
                        <mixed-citation publication-type="journal">22. Zheng X, Wu W, Shen S. Prospective bidirectional associations between depression and chronic kidney diseases. Scientific Reports. 2022;12(1):10903.</mixed-citation>
                    </ref>
                                    <ref id="ref23">
                        <label>23</label>
                        <mixed-citation publication-type="journal">23. Yang Y, Li X, Chen S, Xiao M, Liu Z, Li J, et al. Mechanism and therapeutic strategies of depression after myocardial infarction. Psychopharmacology. 2021;238(6):1401-15.</mixed-citation>
                    </ref>
                                    <ref id="ref24">
                        <label>24</label>
                        <mixed-citation publication-type="journal">24. Kursat S, Colak HB, Toraman A, Ekmekci C, Tekce H, Alici T. The relationship between depression–malnutrition and echocardiographic-blood pressure parameters in chronic hemodialysis patients. International urology and nephrology. 2008;40:793-9.</mixed-citation>
                    </ref>
                                    <ref id="ref25">
                        <label>25</label>
                        <mixed-citation publication-type="journal">25. Cheriex E, Leunissen K, Janssen J, Mooy J, Van Hooff J. Echography of the inferior vena cava is a simple and reliable tool for estimation of ‘dry weight’in haemodialysis patients. Nephrology Dialysis Transplantation. 1989;4(6):563-8.</mixed-citation>
                    </ref>
                                    <ref id="ref26">
                        <label>26</label>
                        <mixed-citation publication-type="journal">26. Koc M, Toprak A, Tezcan H, Bihorac A, Akoglu E, Ozener IC. Uncontrolled hypertension due to volume overload contributes to higher left ventricular mass index in CAPD patients. Nephrology Dialysis Transplantation. 2002;17(9):1661-6.</mixed-citation>
                    </ref>
                                    <ref id="ref27">
                        <label>27</label>
                        <mixed-citation publication-type="journal">27. Çelikdelen, S.Ö., THE EFFECT OF VOLUME STATUS ON QUALITY OF LIFE, ANXIETY, DEPRESSION AND SLEEP QUALITY IN HEMODIALYSIS PATIENTS. Medical Journal of Süleyman Demirel University, 2024. 31(1): p. 71-79.</mixed-citation>
                    </ref>
                                    <ref id="ref28">
                        <label>28</label>
                        <mixed-citation publication-type="journal">28. Kim, Y.K., et al., Relationship between the course of depression symptoms and the left ventricular mass index and left ventricular filling pressure in chronic haemodialysis patients. Nephrology, 2011. 16(2): p. 180-186.</mixed-citation>
                    </ref>
                                    <ref id="ref29">
                        <label>29</label>
                        <mixed-citation publication-type="journal">29. Kurella, M., et al., Cognitive impairment in chronic kidney disease. Journal of the American Geriatrics Society, 2004. 52(11): p. 1863-1869.</mixed-citation>
                    </ref>
                                    <ref id="ref30">
                        <label>30</label>
                        <mixed-citation publication-type="journal">30. McIntyre, C.W. and A. Jain, Dialysis and cognitive impairment. Nature Reviews Nephrology, 2025: p. 1-12.</mixed-citation>
                    </ref>
                                    <ref id="ref31">
                        <label>31</label>
                        <mixed-citation publication-type="journal">31. Jonsson P, Stegmayr C, Stegmayr B, Forsberg U. Venous chambers in clinical use for hemodialysis have limited capacity to eliminate microbubbles from entering the return bloodline: An in vitro study. Artificial Organs. 2023;47(6):961-70.</mixed-citation>
                    </ref>
                                    <ref id="ref32">
                        <label>32</label>
                        <mixed-citation publication-type="journal">32. Westphalen H, Saadati S, Eduok U, Abdelrasoul A, Shoker A, Choi P, et al. Case studies of clinical hemodialysis membranes: Influences of membrane morphology and biocompatibility on uremic blood-membrane interactions and inflammatory biomarkers. Scientific reports. 2020;10(1):14808.</mixed-citation>
                    </ref>
                                    <ref id="ref33">
                        <label>33</label>
                        <mixed-citation publication-type="journal">33. Nakatani TeaSciihpAJN, 86–90 (2003)., Naganuma T, Uchida J, Masuda C, Wada S, Sugimura T, et al. Silent cerebral infarction in hemodialysis patients. American journal of nephrology. 2003;23(2):86-90.</mixed-citation>
                    </ref>
                                    <ref id="ref34">
                        <label>34</label>
                        <mixed-citation publication-type="journal">34. Anazodo UC, Wong DY, Théberge J, Dacey M, Gomes J, Penny JD, et al. Hemodialysis-related acute brain injury demonstrated by application of intradialytic magnetic resonance imaging and spectroscopy. Journal of the American Society of Nephrology. 2023;34(6):1090-104.</mixed-citation>
                    </ref>
                                    <ref id="ref35">
                        <label>35</label>
                        <mixed-citation publication-type="journal">35. Moist LM, McIntyre CW. Cerebral ischemia and cognitive dysfunction in patients on dialysis. Clinical Journal of the American Society of Nephrology. 2019;14(6):914-6.</mixed-citation>
                    </ref>
                                    <ref id="ref36">
                        <label>36</label>
                        <mixed-citation publication-type="journal">36. Wolfgram DF. Intradialytic cerebral hypoperfusion as mechanism for cognitive impairment in patients on hemodialysis. Journal of the American Society of Nephrology. 2019;30(11):2052-8.</mixed-citation>
                    </ref>
                                    <ref id="ref37">
                        <label>37</label>
                        <mixed-citation publication-type="journal">37. Slessarev M, Mahmoud O, Albakr R, Dorie J, Tamasi T, McIntyre CW. Hemodialysis patients have impaired cerebrovascular reactivity to CO2 compared to chronic kidney disease patients and healthy controls: A pilot study. Kidney International Reports. 2021;6(7):1868-77.</mixed-citation>
                    </ref>
                                    <ref id="ref38">
                        <label>38</label>
                        <mixed-citation publication-type="journal">38 Vanderlinden J, Wong DY, Chiu M, McIntyre CW, Jain A. Peritoneal Dialysis Patients Exhibit Quantifiable Neurocognitive Impairment but Not Acute Ischemic Brain Injury: A Magnetic Resonance Spectroscopy and Diffusion Tensor Imaging Study: SA-PO666. Journal of the American Society of Nephrology. 2023;34(11S):913.</mixed-citation>
                    </ref>
                                    <ref id="ref39">
                        <label>39</label>
                        <mixed-citation publication-type="journal">39. Andrews TD, Day GS, Irani SR, Kanekiyo T, Hickson LJ. Uremic Toxins, Chronic Kidney Disease, and Cognitive Dysfunction. Journal of the American Society of Nephrology. 2025:10.1681.</mixed-citation>
                    </ref>
                                    <ref id="ref40">
                        <label>40</label>
                        <mixed-citation publication-type="journal">40. Ghoshal S, O’Connell N, Tegeler C, Freedman BI. Cerebral hemodynamics in peritoneal dialysis versus intermittent hemodialysis: A transcranial Doppler pilot study. Peritoneal Dialysis International. 2021;41(4):417-.</mixed-citation>
                    </ref>
                                    <ref id="ref41">
                        <label>41</label>
                        <mixed-citation publication-type="journal">41. Mantle D. Oxidative stress in peritoneal dialysis: the role of antioxidant supplementation. Journal of Kidney Care. 2024;9(6):281-4.</mixed-citation>
                    </ref>
                                    <ref id="ref42">
                        <label>42</label>
                        <mixed-citation publication-type="journal">42. Massussi M, Bellicini MG, Adamo M, Pilotto A, Metra M, Padovani A, et al. Connecting the dots: A narrative review of the relationship between heart failure and cognitive impairment. ESC heart failure. 2025;12(2):1119-31.</mixed-citation>
                    </ref>
                                    <ref id="ref43">
                        <label>43</label>
                        <mixed-citation publication-type="journal">43. Ye S, Huynh Q, Potter EL. Cognitive dysfunction in heart failure: pathophysiology and implications for patient management. Current Heart Failure Reports. 2022;19(5):303-15.</mixed-citation>
                    </ref>
                                    <ref id="ref44">
                        <label>44</label>
                        <mixed-citation publication-type="journal">44. Loffredo L, Ettorre E, Zicari AM, Inghilleri M, Nocella C, Perri L, et al. Oxidative stress and gut‐derived lipopolysaccharides in neurodegenerative disease: role of NOX2. Oxidative medicine and cellular longevity. 2020;2020(1):8630275.</mixed-citation>
                    </ref>
                                    <ref id="ref45">
                        <label>45</label>
                        <mixed-citation publication-type="journal">45. Romero JR, Beiser A, Himali JJ, Shoamanesh A, DeCarli C, Seshadri S. Cerebral microbleeds and risk of incident dementia: the Framingham Heart Study. Neurobiology of aging. 2017;54:94-9.</mixed-citation>
                    </ref>
                                    <ref id="ref46">
                        <label>46</label>
                        <mixed-citation publication-type="journal">46. Eggermont LH, Aly MF, Vuijk PJ, de Boer K, Kamp O, van Rossum AC, et al. Cardiac function and cognition in older community‐dwelling cardiac patients. Psychogeriatrics. 2017;17(6):356-63.</mixed-citation>
                    </ref>
                                    <ref id="ref47">
                        <label>47</label>
                        <mixed-citation publication-type="journal">47.  Fomin, V., et al., Cognitive impairment in predialysis stages of chronic kidney disease. Zhurnal nevrologii i psikhiatrii imeni SS Korsakova, 2015. 115(12): p. 25-30.</mixed-citation>
                    </ref>
                            </ref-list>
                    </back>
    </article>
