Ekokardiyografik Epikardiyal Yağ Dokusu Kalınlığı ile Hematolojik Parametreler Arasındaki İlişki

Yıl 2019, Cilt: 10 Sayı: 4, 417 - 422, 13.12.2019

İsmail Ateş

Öz

Amaç:
Son zamanlarda özellikle iskemik kalp hastalıkları
olmak üzere pekçok hastalıkta risk ve prognoz tayininde yeni belirteçler
araştırma konusu olmaktadır.  Epikardiyal
yağ dokusu ve hematolojik parametreler (trombosit
sayısı, ortalama trombosit hacmi(MPV), retikulosit dağılım genişliği (RDW),
nötrofil lenfosit oranı (NLR), trombosit lenfosit oranı (PLR)) bu
belirteçlerdendir. Çalışmamızda ekokardiyografi ile ölçülen epikardiyal yağ
dokusu kalınlığı ile hematolojik parametreler arasındaki ilişki
araştırılmıştır.

Metod:
Çalışmaya 136 erkek 87 kadın olmak
üzere 223 kişi dahil edildi. İskemik kalp hastalığı tanısı olanlar çalışmadan
dışlandı. Çalışmaya dahil edilen tüm kişilerin başvuru anında hematolojik
parametreleri ölçüldü ve standart teknik ile transtorasik ekokardiyografi
yapılarak epikardiyal yağ dokusu kalınlıkları hesaplandı. Çalışmaya katılanlar epikardial
yağ dokusu kalınlıklarına göre iki gruba ayrıldı, <0,7cm olan 107 hasta grup
1 ve ≥ 0,7 olan 116 hasta grup 2 olarak belirlendi. Epikardiyal yağ kalınlığı
ile hematolojik parametreler arasındaki ilişki istatiksel yöntemler ile
değerlendirildi.

Bulgular:
Epikardiyal yağ dokusu kalınlığı fazla olan grup
daha yaşlı (ortalama yaş 57,02±10,91 vs. 62,79±9,85; p=0,001) ve daha kiloluydu(vücut kitle indeksi
28,40±4,18 vs. 30,68±5,59; p=0,001).
Grup 2’de diabetes mellitus ve hipertansiyon sıklığı fazlaydı. Hematolojik
parametrelerden yalnızca NLR değeri grup 2’de grup 1’e göre anlamlı
düzeyde yüksek saptandı (1,88±0,72 vs. 2,15±0,85; p=0,028). Epikardiyal yağ dokusu
kalınlığı ile NLR değeri arasında istatiksel anlamlılığa yakın korelasyon
saptandı(R:0,143 p=0,055).

Sonuç:
Ekokardiyografik epikardiyal yağ dokusu kalınlığı
ile hematolojik parametrelerden yalnızca NLR arasında ilişki saptanmıştır. Çalışma
sonucu bu iki belirtecin daha önceki çalışmalarda ortaya konmuş risk ve prognoz
tayinindeki rolünü desteklemektedir.

Anahtar Kelimeler

Epikardiyal yağ dokusu, trombosit sayısı, ortalama trombosit hacmi, retikulosit dağılım genişliği, nötrofil lenfosit oranı, trombosit lenfosit oranı

Destekleyen Kurum

yok

Proje Numarası

yok

Teşekkür

yok

The Relationship Between Echocardiographic Epicardial Fat Tissue Thickness and Haematological Parameters

Öz

Background:
Recently numerous markers for risk assessment are being investigated for many
diseases especially in ischemic heart diseases. Epicardial adipose tissue (EAT)
and hematological parameters (platelet count, mean platelet volume (MPV),
reticulocyte distribution width (RDW), neutrophil-lymphocyte ratio (NLR),
platelet- lymphocyte ratio (PLR) ) are some of these markers. In our study, the
relations between EAT measured by echocardiography and hematologic parameters
were evaluated.

Methods:
A total of 223 consecutive subjects (136 males and 87 females) were enrolled in
the study. The subjects who were diagnosed with ischemic heart disease were
excluded from the study. Hematological parameters and EAT thickness which was
measured with the standard echocardiographic technique of all the subjects who were
included in the study were measured at the time of admission to the hospital.
The participants were divided into two groups according to their EAT
thickness;107 subjects with <0,7 cm were identified as group1, 116 subjects
≥0,7 cm were identified as group 2. The relationship between EAT and
hematological parameters were evaluated.

Results:
The group 2 was older ( mean age 57.02 ± 10.91 vs. 62.79 ± 9.85 ; p = 0.001 )
and more obese ( body mass index 28.40 ± 4.18 vs. 30 , 68 ± 5.59 ; p = 0.001)
then group 1. Group 2 had a greater prevalence of hypertension and diabetes
mellitus. Only NLR values ​​from hematological parameters were found
significantly higher in group 2 compared to group 1 (1,88±0,72 vs. 2,15±0,85;
p=0,028). A correlation close to statistical significance between EAT thickness
and NLR was determined. (R:0,143 p=0,055).

Conclusion:
NLR was the only hematological parameter which relation was determined with
EAT thickness. The study result has strengthened the role in determining the
risk and prognosis of these two markers. 

Anahtar Kelimeler

Epicardial adipose tissue, platelet count, mean platelet volume, reticulocyte distribution width, neutrophil lymphocyte ratio, platelet- lymphocyte ratio

Proje Numarası

yok

Kaynakça

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