sdü tıp fak derg Medical Journal of Süleyman Demirel University 2602-2109 Süleyman Demirel Üniversitesi 10.17343/sdutfd.1056129 Surgery Cerrahi THE EFFECT OF CELIAC DISEASE ON PREGNANCY OUTCOME ÇÖLYAK HASTALIĞININ GEBELİK SONUÇLARI ÜZERİNDEKİ ETKİSİ https://orcid.org/0000-0002-0570-9014 Keleş Ayşe SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA ETLİK ZÜBEYDE HANIM KADIN HASTALIKLARI SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ https://orcid.org/0000-0003-3426-033X Dagdeviren Gulsah SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA ETLİK ZÜBEYDE HANIM KADIN HASTALIKLARI SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ https://orcid.org/0000-0002-7746-1943 Yucel Celik Ozge SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA ETLİK ZÜBEYDE HANIM KADIN HASTALIKLARI SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ https://orcid.org/0000-0002-2664-4424 Özgen Gül SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA ETLİK ZÜBEYDE HANIM KADIN HASTALIKLARI SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ https://orcid.org/0000-0003-1376-5734 İskender Cantekin SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA ETLİK ZÜBEYDE HANIM KADIN HASTALIKLARI SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ https://orcid.org/0000-0001-7033-3474 Çelen Şevki SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA ETLİK ZÜBEYDE HANIM KADIN HASTALIKLARI SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ 09 30 2022 29 3 292 298 01 11 2022 04 27 2022 Copyright © 1994, Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi 1994 Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi

ObjectiveTo investigate the association between celiacdisease (CD), defined as gluten-induced autoimmuneenteropathy in genetically susceptible individuals, andadverse pregnancy and neonatal outcomes and toinvestigate the effects of a gluten-free diet on theseoutcomes.Material and MethodThis retrospective study was conducted betweenpregnant women with CD, who delivered in ourhospital between 2017-2022, and healthy pregnantwomen who delivered during the same period.Patient demographic characteristics, pregnancycomplications, gestational age at delivery, birth weight,and neonatal intensive care needs were analyzed.ResultsDuring the study period, 30 pregnant women withCD were identified. The control group was formedby 90 healthy pregnant women. Maternal age washigher in pregnant women with CD (p=0.020). Therewas no difference between groups in gravidity, parity,abortion, and fertility treatment. Multiple pregnanciesand placenta previa occurred more frequently inthe CD group (p=0.034 and p=0.003, respectively).Preterm births were significantly more common inthe CD group (p=0.000). There were no differencesbetween groups in other pregnancy complications.The gluten-free diet improved pregnancy and neonataloutcomes in the CD group. However, the increase inpreterm birth rate remained compared to the controlgroup (p=0.006).ConclusionCD is associated with preterm birth in pregnancy andadverse neonatal outcomes. Although a gluten-freediet reduces adverse outcomes, the presence of CDcontinues to pose a risk for preterm birth.

AmaçGenetik olarak yatkın kişilerde glutene bağlı otoimmunenteropati olarak tanımlanan Çölyak Hastalığının (ÇH)olumsuz gebelik ve yenidoğan sonuçları ile ilişkisiniaraştırmak ve glütensiz beslenmenin bu sonuçlar üzerindekietkisini incelemektir.Gereç ve YöntemRetrospektif olarak tasarlanan bu çalışma, 2017-2022yılları arasında hastanemizde doğum yapan ÇH olangebeler ile aynı dönemde doğum yapan sağlıklı gebelerarasında gerçekleştirildi. Hastaların demografik verileri,gebelik komplikasyonları, doğum haftası, doğumkilosu ve yenidoğan yoğun bakım ihtiyacı analiz edildi.BulgularÇalışma süresince 30 ÇH olan gebe tespit edildi. Kontrolgrubu 90 sağlıklı gebeden oluşturuldu. ÇH olan gebelerdematernal yaş daha yüksekti (p= 0,020). Gravide,parite, abortus ve fertilite tedavisi açısından gruplararsında farklılık saptanmadı. ÇH grubunda çoğul gebelikve plasenta previa olguları fazla görüldü (p=0,034ve p=0,003). Erken doğum ÇH grubunda anlamlı derecedefazla bulundu (p=0,000). Diğer gebelik komplikasyonlarıaçısından fark saptanmadı. Glutensiz beslenme,ÇH varlığında gebelik ve yenidoğan sonuçlarınıiyileştirmekle birlikte erken doğum kontrol grubundanhala fazla tespit edildi (p=0,006).SonuçÇH, gebelikte erken doğum ve olumsuz yenidoğansonuçları ile ilişkilidir. Glutensiz beslenme olumsuz sonuçlardaazalma yapmakla birlikte ÇH’nın varlığı erkendoğum açısından risk teşkil etmektedir.

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