sdü tıp fak derg

Medical Journal of Süleyman Demirel University

2602-2109

Süleyman Demirel Üniversitesi

10.17343/sdutfd.1162009

Clinical Sciences

Klinik Tıp Bilimleri

A POPULAR COMPLEMENTARY MEDICINE TREATMENT: PROLOTHERAPY

POPÜLER BİR TAMAMLAYICI TIP TEDAVİSİ: PROLOTERAPİ

https://orcid.org/0000-0002-8610-8869

Örsçelik

Aydan

UNIVERSITY OF HEALTH SCIENCES, GÜLHANE SCHOOL OF MEDICINE

https://orcid.org/0000-0002-1959-8159

Solmaz

İlker

Sağlık Bilimleri Üniversitesi Gülhane Sağlık Meslek Yüksekokulu

03 14 2023

30 1 135 142 08 15 2022 09 03 2022

1994

Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi

Prolotherapy, which is a complementary medicinetreatment method used for almost centuries in thetreatment of chronic musculoskeletal diseases, hasbecome popular both in Turkey and in the world in thelast ten years. Prolotherapy practitioners is saying that"prolotherapy method provides improvement in painand functions, increases the quality of life by treatingthe disease". With its widespread usage recently,more studies are being conducted and it is becomingmore evidence-based therapy method. In this review,information supported by the current literature aboutprolotherapy treatment has been conveyed.

Kronik kas iskelet sistemi hastalıklarının tedavisindeneredeyse yüz yıllardır kullanılan bir tamamlayıcı tıptedavi yöntemi olan proloterapi son on yılda hem Türkiyehem de dünyada popüler hale gelmiştir. Proloterapiyönteminin uygulayıcıları tarafından “hastalığıtedavi ederek ağrıda ve fonksiyonlarda iyileşme sağladığı,yaşam kalitesini artırdığı” bilinmektedir. Sondönemde kullanımının yaygınlaşmasıyla birlikte dahaçok çalışma yapılmakta ve kanıta dayandırılmaktadır.Bu derleme ile proloterapi tedavisi hakkında güncelliteratür ile desteklenmiş bilgiler aktarılmıştır.

Ağrı Proloterapi Kas-iskelet sistemi

Musculoskeletal System Pain Prolotherapy

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2. Hackett G, Hemwall G, Montgomery G. Ligament and Tendon Relaxation Treated by Prolotherapy. 5th ed. Oak Park;2008.

3. Solmaz I, Orscelik A. Features and Clinical Effectiveness of the Regenerative Injection Treatments: Prolotherapy and Platelet- Rich Plasma for Musculoskeletal Pain Management. In: Cascella M. From Conventional to Innovative Approaches for Pain Treatment (1st Ed) IntechOpen, 2019;73–86. Doi:10.5772/ intechopen.77716

4. Solmaz I. Kas iskelet sistemi ağrılarında proloterapi uygulamaları. In: Ozlü A. Kas iskelet sistemi hastalıklarında geleneksel ve tamamlayıcı tıp uygulamaları (1st Ed) Ankara, Akademisyen kitabevi, 2020; 153–70.

5. Orscelik A, Akpancar S, Seven MM, Erdem Y, Koca K. The Efficacy of Platelet Rich Plasma and Prolotherapy in Chondromalacia Patella Treatment. Turkish J Sport Med 2020;55(1):28–37.

6. Yıldız Y, Apaydın AH, Seven MM, Orscelik A. The Effects of Prolotherapy (Hypertonic Dextrose) in Recreational Athletes with Patellofemoral Pain Syndrome. J Exp Integr Med 2016;6(2):53.

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9. Rabago D, Lee KS, Ryan M, Chourasia AO, Sesto ME, Zgierska A, et al. Hypertonic dextrose and morrhuate sodium injections (prolotherapy) for lateral epicondylosis (tennis elbow): Results of a single-blind, pilot-level, randomized controlled trial. Am J Phys Med Rehabil 2013;92(7):587–96.

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19. Solmaz I, Akpancar S, Orscelik A, Yener-Karasimav O, Gül D. Dextrose injections for failed back surgery syndrome: a consecutive case series. Eur Spine J 2019:21;28(7):1610–7.

20. Maniquis-Smigel L, Dean Reeves K, Jeffrey Rosen H, Lyftogt J, Graham-Coleman C, Cheng A-L, et al. Short Term Analgesic Effects of 5% Dextrose Epidural Injections for Chronic Low Back Pain: A Randomized Controlled Trial. Anesthesiol Pain Med 2016;7(1):e42550.

21. Köroğlu O, Orscelik A, Karasimav Ö, Demir Y, Solmaz I. Is 5% dextrose prolotherapy effective for radicular low back pain? Gulhane Med J 2019;61(3):123.

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27. Dagenais S, Haldeman S, Wooley JR. Intraligamentous injection of sclerosing solutions (prolotherapy) for spinal pain: a critical review of the literature. Spine J 2005;5(3):310–28.

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29. Miller, Matthew R, Matthews, Robert S RKD. Treatment of painful advanced internal lumbar disc derangement with intradiscal injection of hypertonic dextrose. Pain Physician 2006;9(2):115–21.

30. Solmaz İ, Orscelik A. Approximately Three Years of Prolotherapy Experience of a Traditional and Complementary Medicine Center: An Epidemiologic Study. Int J Tradit Complement Med Res 2022;3(2):64–70.

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34. Centeno CJ, Elliott J, Elkins WL, Freeman M. Fluoroscopically guided cervical prolotherapy for instability with blinded pre and post radiographic reading. Pain Physician 2005;8(1):67–72.

35. Hooper RA, Frizzell JB, Faris P. Case series on chronic whiplash related neck pain treated with intraarticular zygapophysial joint regeneration injection therapy. Pain Physician 2007;10(2):313–8.

36. DeChellis DM, Cortazzo MH. Regenerative medicine in the field of pain medicine: Prolotherapy, platelet-rich plasma therapy, and stem cell therapy—Theory and evidence. Tech Reg Anesth Pain Manag 2011;15(2):74–80.

37. Hung C-Y, Hsiao M-Y, Chang K-V, Han D-S, Wang T-G. Comparative effectiveness of dextrose prolotherapy versus control injections and exercise in the management of osteoarthritis pain: a systematic review and meta-analysis. J Pain Res 2016;9:847–57.

38. Rabago D, Patterson JJ, Mundt M, Kijowski R, Grettie J, Segal NA, et al. Dextrose Prolotherapy for Knee Osteoarthritis: A Randomized Controlled Trial. Ann Fam Med 20131;11(3):229–37.

39. Reeves KD, Hassanein KM. Long-term effects of dextrose prolotherapy for anterior cruciate ligament laxity. Altern Ther Health Med 2003;9(3):58–62.

40. Rabago D, Zgierska A, Fortney L, Kijowski R, Mundt M, Ryan M, et al. Hypertonic Dextrose Injections (Prolotherapy) for Knee Osteoarthritis: Results of a Single-Arm Uncontrolled Study with 1-Year Follow-Up. J Altern Complement Med 2012;18(4):408–14.

41. Rezasoltani Z, Taheri M, Kazempour Mofrad M, Mohajerani S. Periarticular dextrose prolotherapy instead of intra-articular injection for pain and functional improvement in knee osteoarthritis. J Pain Res 2017;10:1179–87.

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43. Scarpone M, Rabago DP, Zgierska A, Arbogast G, Snell E. The Efficacy of Prolotherapy for Lateral Epicondylosis: A Pilot Study. Clin J Sport Med 2008;18(3):248–54.

44. Akcay S, Gurel Kandemir N, Kaya T, Dogan N, Eren M. Dextrose Prolotherapy Versus Normal Saline Injection for the Treatment of Lateral Epicondylopathy: A Randomized Controlled Trial. J Altern Complement Med 2020;26(12):1159–68.

45. Yelland M, Rabago D, Ryan M, Ng S-K, Vithanachchi D, Manickaraj N, et al. Prolotherapy injections and physiotherapy used singly and in combination for lateral epicondylalgia: a single- blinded randomised clinical trial. BMC Musculoskelet Disord 2019;20(1):509.

46. Bertrand H, Reeves KD, Bennett CJ, Bicknell S, Cheng A-L. Dextrose Prolotherapy Versus Control Injections in Painful Rotator Cuff Tendinopathy. Arch Phys Med Rehabil 2016;97(1):17–25.

47. Sari A, Eroglu A. Comparison of ultrasound-guided platelet-rich plasma, prolotherapy, and corticosteroid injections in rotator cuff lesions. J Back Musculoskelet Rehabil 2020;33(3):387–96.

48. Lin C-L, Huang C-C, Huang S-W. Effects of hypertonic dextrose injection in chronic supraspinatus tendinopathy of the shoulder: a randomized placebo-controlled trial. Eur J Phys Rehabil Med 2019; 55(4):480-7.

49. Chang Y-J, Chang F-H, Hou P-H, Tseng K-H, Lin Y-N. Effects of Hyperosmolar Dextrose Injection in Patients With Rotator Cuff Disease and Bursitis: A Randomized Controlled Trial. Arch Phys Med Rehabil 2021;102(2):245–50.

50. Akpancar S, Orscelik A, Murat SM, Kenan K. The effectiveness of prolotherapy on failed rotator cuff repair surgery. Turkish J Phys Med Rehabil 2019;65(4):394–401.

51. Rabago D, Nourani B. Prolotherapy for Osteoarthritis and Tendinopathy: a Descriptive Review. Curr Rheumatol Rep 2017;19(6):34.

52. Apaydin AH, Orscelik A, Yildiz Y. The Effects of Prolotherapy in Recreational Athletes with Plantar Fasciitis. Turkish J Sport Med 2018;53(1):37–46.

53. Solmaz İ, Orscelik A, Akpancar S, Seven MM. The Effectivity Of Prolotherapy Treatment In Shin Splint: A Randomized Controlled Study. Int J Tradit Complement Med Res 2022;3(1):1–7.