sdü tıp fak derg

Medical Journal of Süleyman Demirel University

2602-2109

Süleyman Demirel Üniversitesi

10.17343/sdutfd.1164324

Clinical Sciences

Klinik Tıp Bilimleri

THE POSSIBLE ROLE OF MIR-1910-3P, MIR-4649-3P, MIR-4296, AND MIR-210 IN THE PATHOGENESIS OF ATOPIC DERMATITIS: MAY MIR-4296 PLAY CRUCIAL ROLES IN THE DEVELOPMENT OF ATOPIC DERMATITIS?

ATOPİK DERMATİT PATOGENEZİNDE MİR-1910-3P, MİR-4649-3P, MİR-4296 VE MİR-210'UN OLASI ROLÜ: MİR-4296 ATOPİK DERMATİT GELİŞİMİNDE ÖNEMLİ ROL OYNAYABİLİR Mİ?

https://orcid.org/0000-0002-6576-2431

Ayvaz

Havva Hilal

SÜLEYMAN DEMİREL ÜNİVERSİTESİ

https://orcid.org/0000-0002-7075-8875

Hekimler Öztürk

Kuyaş

SÜLEYMAN DEMİREL ÜNİVERSİTESİ, TIP FAKÜLTESİ

https://orcid.org/0000-0002-6581-8626

Atay

Emrah

Public health expertise, Eskişehir Provincial Health Directorate, Eskişehir/Turkey

https://orcid.org/0000-0002-0640-2292

Erturan

İjlal

SÜLEYMAN DEMİREL ÜNİVERSİTESİ, TIP FAKÜLTESİ

https://orcid.org/0000-0003-3877-3976

Korkmaz

Selma

SÜLEYMAN DEMİREL ÜNİVERSİTESİ, TIP FAKÜLTESİ

https://orcid.org/0000-0003-3373-9074

Yıldırım

Mehmet

SÜLEYMAN DEMİREL ÜNİVERSİTESİ, TIP FAKÜLTESİ

09 30 2022

29 3 494 503 08 19 2022 09 02 2022

1994

Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi

ObjectiveAtopic dermatitis (AD) is a chronic inflammatory skindisease with unexplained points in its pathogenesis.Altered expressions of microRNAs (miRNA, miR) inplasma can serve as markers that distinguish diseasedindividuals from healthy controls AD. In the presentstudy, plasma expression levels of miR-1910-3p, miR-4649-3p, miR-4296 and miR-210 were investigated inAD.Material and MethodForty patients with AD and forty healthy control subjectswere included in the present study. Quantitative realtimePCR was used to measure miRNAs.ResultsThe mean plasma miR-4296 level was higher in thepatient group (p < 0.001). There was a significantnegative correlation between SCORAD scores andmiR-210 levels (r:-0.340, p=0.032). miR-210 levelsdecreased with increasing disease severity. In logisticregression analyses, an increase in plasma miR-4296levels was found to be statistically significant (OR=5.464, p

AmaçAtopik dermatit (AD), patogenezinde açıklanamayannoktaları olan kronik inflamatuar bir deri hastalığıdır.Plazmadaki mikroRNA'ların (miRNA, miR) değişmişekspresyonları, hastalıklı bireyleri sağlıklı kontrollerdenayıran belirteçler olarak hizmet edebilir. Bu çalışmada,AD’li hastalarda miR-1910-3p, miR-4649-3p,miR-4296 ve miR-210'un plazma ekspresyon düzeyleriaraştırıldı.Gereç ve YöntemBu prospektif çalışmaya 40 AD'li hasta ve 40 sağlıklıkontrol alındı. MiRNA'ları ölçmek için real-time PCRkullanıldı.BulgularOrtalama plazma miR-4296 düzeyi hasta grupta dahayüksek bulundu (p < 0.001). SCORAD skorları ilemiR-210 seviyeleri arasında anlamlı bir negatif korelasyonsaptandı (r:-0.340, p=0.032). miR-210 seviyelerihastalık şiddeti arttıkça azalmaktaydı. Lojistik regresyonanalizinde plazma miR-4296 seviyelerinde birartış istatistiksel olarak anlamlı bulundu (OR =5.464,p

Atopic dermatitis miR-4296 miR-1910-3p miR-210 SCORAD

Atopik dermatit miR-4296 miR-1910-3p miR-210 SCORAD

1. Avena-Woods C. Overview of atopic dermatitis. The American journal of managed care 2017;23(8):115-123.

2. David Boothe W, Tarbox JA, Tarbox MB. Atopic Dermatitis: Pathophysiology. Advances in experimental medicine and biology 2017;1027:21-37. doi: 10.1007/978-3-319-64804-0_3.

3. Carroll CL, Balkrishnan R, Feldman SR, Fleischer AB Jr, Manuel JC. The burden of atopic dermatitis: impact on the patient, family, and society. Pediatric Dermatology. 2005;22(3):192-199. doi: 10.1111/j.1525-1470.2005.22303.x.

4. Peng W, Novak N. Pathogenesis of atopic dermatitis. Clinical and experimental allergy: journal of the British Society for Allergy and Clinical Immunology 2015;45(3):566-574. doi: 10.1111/cea.12495.

5. Makeyev EV, Maniatis T. Multilevel regulation of gene expression by microRNAs. Science 2008;319(5871):1789-1790. doi: 10.1126/science.1152326

6. Schneider MR. MicroRNAs as novel players in skin development, homeostasis and disease. The British journal of dermatology 2012;166(1):22-28. doi: 10.1111/j.1365-2133.2011.10568.x.

7. Yu X, Wang M, Li L, Zhang L, Chan MTV, et al. MicroRNAs in atopic dermatitis: A systematic review. Journal of cellular and molecular medicine, 2020; 24(11):5966-5972. doi: 10.1111/jcmm.15208

8. Lawrie CH, Gal S, Dunlop HM, Pushkaran B, Liggins AP, et al. Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma. British journal of haematology 2008; 141(5):672-675. doi: 10.1111/j.1365-2141.2008.07077.x.

9. Zampetaki A, Kiechl S, Drozdov I, Willeit P, Mayr U, et al. Plasma microRNA profiling reveals loss of endothelial miR-126 and other microRNAs in type 2 diabetes. Circulation research 2010;107(6):810-817. doi: 10.1161/CIRCRESAHA.110.226357.

10. Rashmi R, Rao KS, Basavaraj KH. A comprehensive review of biomarkers in psoriasis. Clinical and experimental dermatology 2009; 34(6):658-663. doi: 10.1111/j.1365-2230.2009.03410.x.

11. Sullivan M, Silverberg NB. Current and emerging concepts in atopic dermatitis pathogenesis. Clinics in dermatology 2017; 35(4):349-353. doi: 10.1016/j.clindermatol.2017.03.006.

12. Klonowska J, Gleń J, Nowicki RJ, Trzeciak M. New Cytokines in the Pathogenesis of Atopic Dermatitis-New Therapeutic Targets. International journal of molecular sciences 2018;19(10):3086. doi: 10.3390/ijms19103086.

13. Rożalski M, Rudnicka L, Samochocki Z. MiRNA in atopic dermatitis. Postepy dermatologii i alergologii 2016;33(3):157-162. doi: 10.5114/ada.2016.60606.

14. Chen X, Ba Y, Ma L, Cai X, Yin Y, et al. Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases Cell research 2008, 18: 997–1006. doi: 10.1038/cr.2008.282.

15. Long CM, Lukomska E, Marshall NB, Nayak A, Anderson SE. Potential Inhibitory Influence of miRNA 210 on Regulatory T Cells during Epicutaneous Chemical Sensitization. Genes (Basel). 2016;8(1):9. doi:10.3390/genes8010009

16. Bartel S, La Grutta S, Cilluffo G, et al. Human airway epithelial extracellular vesicle miRNA signature is altered upon asthma development. Allergy. 2020;75(2):346-356. doi:10.1111/all.14008

17. O'Sullivan MJ, Jang JH, Panariti A, et al. Airway Epithelial Cells Drive Airway Smooth Muscle Cell Phenotype Switching to the Proliferative and Pro-inflammatory Phenotype. Front Physiol. 2021;12:687654. doi:10.3389/fphys.2021.687654.

18. Hanifin, JM, Rajka, G. Diagnostic features of atopic dermatitis. Acta Dermato-Venereologica 1980; 92:44-47. doi: 10.2340/00015555924447

19. Severity scoring of atopic dermatitis: the SCORAD index. Consensus Report of the European Task Force on Atopic Dermatitis. Dermatology. 1993;186(1):23-31. doi: 10.1159/000247298.

20. Cortez MA, Bueso-Ramos C, Ferdin J, Lopez-Berestein G, Sood AK, et al. MicroRNAs in body fluids: the mix of hormones and biomarkers. Nature reviews. Clinical oncology 2011; 8: 467-477. doi: 10.1038/nrclinonc.2011.76.

21. Bin L, Leung DY. Genetic and epigenetic studies of atopic dermatitis. Allergy and Clinical Immunology 2016;12:52. doi: 10.1186/s13223-016-0158-5.

22. Bhardwaj N. MicroRNAs in atopic dermatitis: A review. Journal of translational genetics and genomics 2017;1: 15-22. doi: 10.20517/jtgg.2017.01

23. Sonkoly E, Wei T, Janson PC, Sääf A, Lundeberg L, et al. MicroRNAs: Novel regulators involved in the pathogenesis of psoriasis? PLoS One 2007;2: e610. doi: 10.1371/journal.pone.0000610.

24. Nousbeck J, McAleer MA, Hurault G, Kenny E, Harte K, et al. MicroRNA analysis of childhood atopic dermatitis reveals a role for miR‐451a*. British journal of dermatology 2021; 184: 514-523. doi: 10.1111/bjd.19254.

25. Lv Y, Qi R, Xu J, Di Z, Zheng H, et al. Profiling of serum and urinary microRNAs in children with atopic dermatitis. PLoS One. 2014; 22;9(12):e115448. doi: 10.1371/journal.pone.0115448.

26. Koga Y, Jinnin M, Ichihara A, Fujisawa A, Moriya C, et al. Analysis of expression pattern of serum microRNA levels in patients with psoriasis. Journal of dermatological science 2014;74(2):170-171. doi: 10.1016/j.jdermsci.2014.01.005.

27. Yan F, Meng W, Ye S, Zhang X, Mo X, et al. MicroRNA-146a as a potential regulator involved in the pathogenesis of atopic dermatitis. Molecular medicine reports 2019;20(5):4645-4653. doi: 10.3892/mmr.2019.10695.

28. Dissanayake E, Inoue Y, Ochiai S, Eguchi A, Nakano T, et al. Hsa-mir-144-3p expression is increased in umbilical cord serum of infants with atopic dermatitis. The Journal of allergy and clinical immunology 2019;143(1):447.e11-450.e11. doi: 10.1016/j.jaci.2018.09.024.

29. Gu C, Li Y, Wu J, Xu J. IFN-γ-induced microRNA-29b up-regulation contributes to keratinocyte apoptosis in atopic dermatitis through inhibiting Bcl2L2. International journal of clinical and experimental pathology 2017;10(9):10117-10126.

30. Herberth G, Bauer M, Gasch M, Hinz D, Röder S, et al. Maternal and cord blood miR-223 expression associates with prenatal tobacco smoke exposure and low regulatory T-cell numbers. The Journal of allergy and clinical immunology 2014;133(2):543-550. doi: 10.1016/j.jaci.2013.06.036.

31. Karabacak M, Erturan İ, Hekimler Öztürk K, Ayvaz HH, Korkmaz S, et al. 'Is microrna 1910-3p (miR-1910-3p) a really distinctive marker for psoriasis?'. Turkish journal of medical sciences 2020; 28. doi: 10.3906/sag-2009-156.

32. Wu R, Zeng J, Yuan J, Deng X, Huang Y, et al. MicroRNA-210 overexpression promotes psoriasis-like inflammation by inducing Th1 and Th17 cell differentiation. The Journal of clinical investigation 2018;128(6):2551-2568. doi: 10.1172/JCI97426.

33. Feng H, Wu R, Zhang S, Kong Y, Liu Z, et al. Topical administration of nanocarrier miRNA-210 antisense ameliorates imiquimod-induced psoriasis-like dermatitis in mice. The Journal of dermatology 2020;47(2):147-154. doi: 10.1111/1346-8138.15149.

34. Papadavid E, Braoudaki M, Bourdakou M, Lykoudi A, Nikolaou V, et al. Aberrant microRNA expression in tumor mycosis fungoides. Tumour biology 2016; 37(11):14667-14675. doi: 10.1007/s13277-016-5325-2.

35. Wang B, Mao JH, Wang BY, Wang LX, Wen HY, et al. Exosomal miR-1910-3p promotes proliferation, metastasis, and autophagy of breast cancer cells by targeting MTMR3 and activating the NF-κB signaling pathway. Cancer letters 2020;489:87-99. doi: 10.1016/j.canlet.2020.05.038.

36. Shen Y, Gao X, Tan W, Xu T. STAT1-mediated upregulation of lncRNA LINC00174 functions a ceRNA for miR-1910-3p to facilitate colorectal carcinoma progression through regulation of TAZ. Gene 2018;666:64-71. doi: 10.1016/j.gene.2018.05.001.

37. Bustos MA, Gross R, Rahimzadeh N, Cole H, Tran LT, et al. A Pilot Study Comparing the Efficacy of Lactate Dehydrogenase Levels Versus Circulating Cell-Free microRNAs in Monitoring Responses to Checkpoint Inhibitor Immunotherapy in Metastatic Melanoma Patients. Cancers 2020;12(11):3361. doi: 10.3390/cancers12113361.

38. Mullany LE, Herrick JS, Wolff RK, Stevens JR, Slattery ML. Association of cigarette smoking and microRNA expression in rectal cancer: Insight into tumor phenotype. Cancer Epidemiol. 2016;45:98-107. doi:10.1016/j.canep.2016.10.011