sdü tıp fak derg

Medical Journal of Süleyman Demirel University

2602-2109

Süleyman Demirel Üniversitesi

10.17343/sdutfd.1172871

Surgery

Cerrahi

EVALUATION OF IMMUNOHISTOCHEMICAL NEOVASCULAR PSMA AND CD34 EXPRESSIONS IN THYROID TUMORS

TİROİD TÜMÖRLERİNDE İMMÜNOHİSTOKİMYASAL OLARAK NEOVASKÜLER PSMA VE CD34 EKSPRESYONLARININ DEĞERLENDİRİLMESİ

https://orcid.org/0000-0003-3292-2213

Kıran

Mehmet

SÜLEYMAN DEMİREL ÜNİVERSİTESİ, TIP FAKÜLTESİ, TIP PR.

https://orcid.org/0000-0002-5619-4989

Çiriş

İbrahim Metin

SULEYMAN DEMIREL UNIVERSITY

03 14 2023

30 1 79 88 09 09 2022 02 27 2023

1994

Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi

ObjectiveThe aim of this study was to investigate the placeof Prostate Specific Membrane Antigen (PSMA)expression in differential diagnosis and its effect onprognosis in thyroid tumors.Material and MethodImmunohistochemical PSMA and CD34 were appliedto paraffin blocks of 95 patients diagnosed withdifferent histological types of thyroid cancer. Thepercentage of vascular expression in the tumoral andextratumoral stroma and the density score in the tumorepithelium were evaluated and grouped according toPSMA expression level. Final PSMA expression wasdetermined by multiplying intensity and percentagepoints.An increase in expression was observed with PSMAin areas with neovascularization in thyroid tumors. Novascular staining was detected with PSMA in nonneoplasticthyroid tissue. No increase in expressionwas seen in Non-invasive folicular thyroid neoplasmwith papillary like nuclear features (NIFTP) casescompared to aggressive tumorsConclusionIt was determined that increased PSMA expressionwas associated with poor prognosis, and it was foundthat it can be used to differentiate NIFTP cases fromother tumors.

AmaçBu çalışmanın amacı tiroid tümörlerinde Prostat SpesifikMembran Antijen (PSMA) ekspresyonunun ayrıcıtanıdaki yeri ve prognoz üzerine etkisinin araştırılmasıdır.Gereç ve YöntemFarklı histolojik tipteki 95 tiroid kanseri tanısı alan hastalarınparafin bloklarına immünohistokimyasal PSMAve CD34 uygulandı. Tümöral ve ekstratümoral stromadakivasküler ekspresyon yüzdesi ve tümör epitelindekiyoğunluk skoru değerlendirildi ve PSMA ekspresyondüzeyine göre gruplara ayrıldı. Nihai PSMAifadesi, yoğunluk ve yüzde puanları çarpılarak belirlendi.BulgularTiroid tümörlerinde yeni damar oluşumu olan alanlardaPSMA ile ekspresyon artışı izlendi. Non-neoplastiktiroid dokusunda PSMA ile vasküler boyanma saptanmadı.Papiller Benzeri Nükleer Özellikler GösterenNoninvaziv Foliküler Neoplazi (NİFTP) vakalarındaagresif tümörlere göre karşılaştırıldığında ekspresyonartışı görülmediSonuçPSMA ekspresyon artışının kötü prognozla ilişkili olduğusaptandı ve NİFTP vakalarının diğer tümörler ileayrımında kullanılabileceği yönünde bulgular saptandı

Neovaskülarizasyon PSMA ekspresyonu Tiroid Karsinomu

Neovascular PSMA Expression Thyroid Cancer

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