sdü tıp fak derg

Medical Journal of Süleyman Demirel University

2602-2109

Süleyman Demirel Üniversitesi

10.17343/sdutfd.1179733

Clinical Sciences

Klinik Tıp Bilimleri

EVALUATION OF INFLAMMATION-RELATED HEMOGRAM PARAMETERS AS A USEFUL MARKER IN PAPILLARY THYROID CARCINOMA

PAPİLLER TİROİD KARSİNOMUNDA YARARLI BİR BELİRTEÇ OLARAK İNFLAMASYONLA İLİŞKİLİ HEMOGRAM PARAMETRELERİNİN DEĞERLENDİRİLMESİ

https://orcid.org/0000-0002-8428-1115

Sözen

Mehmet

KOCAELİ ÜNİVERSİTESİ, TIP FAKÜLTESİ

https://orcid.org/0000-0001-7114-2565

Cantürk

Zeynep

KOCAELI UNIVERSITY, SCHOOL OF MEDICINE

https://orcid.org/0000-0002-0646-8697

Selek

Alev

KOCAELI UNIVERSITY, SCHOOL OF MEDICINE

https://orcid.org/0000-0002-8041-8161

Çetinaslan

Berrin

KOCAELI UNIVERSITY, SCHOOL OF MEDICINE

https://orcid.org/0000-0002-0287-3716

Sevinç

Burcu

KOCAELI UNIVERSITY, SCHOOL OF MEDICINE

https://orcid.org/0000-0002-5340-6106

Gezer

Emre

KOCAELI UNIVERSITY, SCHOOL OF MEDICINE

https://orcid.org/0000-0002-6349-2976

Köksalan

Damla

KOCAELI UNIVERSITY, SCHOOL OF MEDICINE

12 27 2022

29 4 611 618 09 24 2022 10 27 2022

Copyright © 1994, Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi

1994

Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi

ObjectiveInflammation-related hemogram parameters haverecently started to be defined as a useful marker incancer patients. In this study, we aimed to comparisonof hemogram parameters in papillary thyroid cancer(PTC) patients, well differentiated thyroid tumorof uncertain malignant potential (WDT-UMP) andfollicular adenoma (FA).Material and MethodThe 287 patients’ data were analyzed in study. Studysubjects were divided into 5 different groups. 1stgroup: control, 2nd group: FA, 3rd group: WDT-UMP,4th group: non-metastatic PTC, 5th group: metastaticPTC. We evaluated the preoperative blood tests.ResultsThe average age was 50 (37-59). The mean TSHvalue was 1.2 (0.5-2.2) μIU/mL. The mean size of thelesion detected in the total thyroidectomy material was1.7 (1.0-3.0) cm. White blood cells (WBC), neutrophilsand lymphocytes were lower in 3rd group than 4thgroup (p

Amaçİnflamasyona bağlı hemogram parametreleri son zamanlardakanser hastalarında faydalı bir belirteç olaraktanımlanmaya başlamıştır. Bu çalışmada, papillertiroid kanserli (PTC), malignite potansiyeli belirsiz iyidiferansiye tiroid tümörü ve foliküler adenomlu (FA)hastalarda hemogram parametrelerinin karşılaştırılmasıamaçlandı.Gereç ve YöntemÇalışmada 287 hastanın verileri analiz edildi. Çalışmapopülasyonu 5 farklı gruba ayrıldı. 1. Grup: kontrol, 2.grup: FA, 3. grup: WDT-UMP, 4. grup: metastatik olmayanPTC, 5. grup: metastatik PTC. Ameliyat öncesiyapılan kan testlerini değerlendirdik.BulgularOrtalama yaş 50 (37-59) idi. Ortalama TSH değeri 1.2(0.5-2.2) μIU/mL idi. Total tiroidektomi materyalindesaptanan lezyonun ortalama boyutu 1.7 (1.0-3.0) cmidi. Grup 3'te beyaz kan hücreleri (WBC), nötrofillerve lenfositler grup 4'e göre daha düşüktü (p

papillary thyroid cancer WDT-UMP follicular adenoma MPV RDW

papiller tiroid kanseri WDT-UMP foliküler adenom MPV RDW

yok

YOK

1

1. Hsu DS, Kim MK, Balakumaran BS, et al. Immune signatures predict prognosis in localized cancer. Cancer Investigation. 2010;28(7):765-73.

2

2. Balkwill F, Mantovani A. Inflammation and cancer: Back to Virchow? Vol. 357, Lancet. Elsevier Limited; 2001. p. 539–45.

3

3. Coussens LM, Werb Z. Inflammation and cancer. Nature. 2002;420(6917):860-7.

4

4. Ari A, Gunver F. Comparison of neutrophil–lymphocyte ratio and platelet–lymphocyte ratio in patients with thyroiditis and papillary tumors. Journal of International Medical Research. 2019;47(5):2077-83.

5

5. Yokota M, Katoh H, Nishimiya H, et al. Lymphocyte-monocyte ratio significantly predicts recurrence in papillary thyroid cancer. Journal of Surgical Research. 2020;246:535-43.

6

6. Çölkesen F. Pankreas kanserli hastalarda hematolojik parametrelerin (mean platelet volume, nötrofil/lenfosit oranı, trombosit/ lenfosit oranı, eozinofil ve lenfosit sayısı) prognoz - tedavi takibinde kullanılabilirliklerinin araştırılması. Selçuk Üniversitesi, Yayımlanmış Uzm tezi, Kony. 2015.

7

7. Lang BH, Ng CP, Au KB, et al. Does preoperative neutrophil lymphocyte ratio predict risk of recurrence and occult central nodal metastasis in papillary thyroid carcinoma?. World journal of surgery. 2014:2605-12.

8

8. Lian L, Xia YY, Zhou C, et al. Mean platelet volume predicts chemotherapy response and prognosis in patients with unresectable gastric cancer. Oncology letters. 2015;10(6):3419-24.

9

9. Hussein O, Abdelwahab K, Hamdy O, et al. Thyroid cancer associated with Hashimoto thyroiditis: similarities and differences in an endemic area. Journal of the Egyptian National Cancer Institute. 2020;32(1):1-4.

10

10. Li MM, Yue CX, Fu S, et al. Platelet volume is reduced in metastasing breast cancer: Blood profiles reveal significant shifts. Cancer Management and Research. 2019;11:9067.

11

11. Lai X, Xia Y, Zhang B, et al. A meta-analysis of Hashimoto’s thyroiditis and papillary thyroid carcinoma risk. Oncotarget. 2017;8(37):62414.

12

12. Wang X, Cui MM, Xu Y, et al. Decreased mean platelet volume predicts poor prognosis in invasive bladder cancer. Oncotarget. 2017;8(40):68115.

13

13. Feng J, Wang Y, Shan G, et al. Clinical and prognostic value of neutrophil-lymphocyte ratio for patients with thyroid cancer: A meta-analysis. Medicine. 2020;99(20).

14

14. Al-Kindi SG, Refaat M, Jayyousi A, et al. Red cell distribution width is associated with all-cause and cardiovascular mortality in patients with diabetes. BioMed research international. 2017;2017.

15

15. Sit M, Aktas G, Ozer B, et al. Mean platelet volume: an overlooked herald of malignant thyroid nodules. Acta Clinica Croatica. 2019;58(3):417.

16

16. Montagnana M, Danese E. Red cell distribution width and cancer. Annals of translational medicine. 2016;4(20).

17

17. Paliogiannis P, Scognamillo F, Bellomo M, e al. Neutrophil to lymphocyte ratio as a predictor of thyroid papillary carcinoma. Acta Med Mediterr. 2015;31:371-5.

18

18. Hu L, Li M, Ding Y, et al. Prognostic value of RDW in cancers: a systematic review and meta-analysis. Oncotarget. 2017;8(9):16027.

19

19. Liu CL, Lee JJ, Liu TP, et al. Blood neutrophil‐to‐lymphocyte ratio correlates with tumor size in patients with differentiated thyroid cancer. Journal of surgical oncology. 2013;107(5):493-7.

20

20. Aktas G, Sit M, Karagoz I, et al. Could red cell distribution width be a marker of thyroid cancer. J Coll Physicians Surg Pak. 2017;27(9):556-8.

21

21. Liu JF, Ba L, Lv H, et al. Association between neutrophil-to-lymphocyte ratio and differentiated thyroid cancer: a meta-analysis. Scientific reports. 2016;6(1):1-7.

22

22. Sevinc B, Karahan O, Ay S, et al. Red cell distribution width as a marker of thyroid papillary carcinoma. Translational Surgery. 2016;1(2):41-.

23

23. Pyo JS, Sohn JH, Kang G. Diagnostic and prognostic roles of the mean platelet volume in malignant tumors: a systematic review and meta-analysis. Platelets. 2016;27(8):722-8.

24

24. Kayilioglu SI, Dinc T, Sozen I, et al. Thyroid nodules with atypia or follicular lesions of undetermined significance (AUS/FLUS): analysis of variables associated with outcome. Asian Pacific Journal of Cancer Prevention. 2015;15(23):10307-11.

25

25. Ozmen HK, Askin S, Simsek E, et al. Mean Platelet Volume and Red Cell Distribution Width in Differentiated Thyroid Cancer Patients. Open Medicine Journal. 2019;6(1).

26

26. Dincel O, Bayraktar C. Evaluation of platelet indices as a useful marker in papillary thyroid carcinoma. Bratislava Med J. 2017;118(3):153-5.

27

27. Yu YJ, Li N, Yun ZY, et al. Preoperative mean platelet volume and platelet distribution associated with thyroid cancer. Neoplasma. 2017;64(4):594-8.

28

28. Li N, Fu S, Cui MM, et al. Platelet distribution width and serum albumin levels for discrimination of thyroid cancer from benign thyroid nodules. Asian Pacific Journal of Cancer Prevention: APJCP. 2017;18(7):1773.

29

29. Yagyu T, Saito H, Sakamoto T, et al. Decreased mean platelet volume predicts poor prognosis in patients with pancreatic cancer. BMC surgery. 2021;21(1):1-8.

30

30. Delago D, Knittelfelder O, Jakse G, et al. The decreased mean platelet volume is associated with poor prognosis in patients with oropharyngeal cancer treated with radiotherapy. Radiation Oncology. 2020;15(1):1-2.