sdü tıp fak derg

Medical Journal of Süleyman Demirel University

2602-2109

Süleyman Demirel Üniversitesi

10.17343/sdutfd.1193868

Surgery Clinical Sciences

Cerrahi Klinik Tıp Bilimleri

PROGNOSTIC IMPORTANCE OF THE LYMPH NODE RATIO IN STAGE III COLORECTAL CANCERS

EVRE III KOLOREKTAL KANSERLERDE LENF NODU POZİTİFLİK ORANININ PROGNOSTİK ÖNEMİ

https://orcid.org/0000-0001-9193-5327

Erdoğan

Kübra

SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA DR. ABDURRAHMAN YURTASLAN ONKOLOJİ SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ

https://orcid.org/0000-0002-6401-1716

Yılmaz

Nisbet

SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ

https://orcid.org/0000-0002-0126-4679

Erdoğan

Ahmet

Medisun Hospital

https://orcid.org/0000-0003-3835-2741

Sütçüoğlu

Osman

GAZİ ÜNİVERSİTESİ, TIP FAKÜLTESİ

https://orcid.org/0000-0003-0038-3569

Yazıcı

Ozan

GAZİ ÜNİVERSİTESİ, TIP FAKÜLTESİ

https://orcid.org/0000-0002-9235-9592

Yıldırım Özdemir

Nuriye

GAZİ ÜNİVERSİTESİ, TIP FAKÜLTESİ

12 27 2022

29 4 661 670 10 26 2022 11 30 2022

1994

Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi

ObjectiveColorectal cancers (CRCs) are among the most com-mon cancers all over the world with a high mortalityrate. Many prognostic factors have been identified forthese cancers, one of which is the lymph node ratio(LNR). The purpose of this study was to reveal theprognostic importance of the LNR in stage III CRCs.Material and MethodThe records of stage III colorectal patients who receivedadjuvant chemotherapy between January 1998and May 2014 were examined retrospectively. Similarto the literature, the patients were divided into threegroups according to their LNRs. Those with a ratio of0–0.20 were in the 1st group, with 0.21–0.50 were inthe 2nd group, and with 0.51–1 were in the 3rd group.Demographic characteristics of the patients, numberof positive and total lymph nodes removed, lymphnode positivity rate, presence of free tumor nodules,and survival were evaluated.ResultsA total of 263 patients were included in the study. While163 (61.9%) of the patients were male, the medianage was 62 (min: 25–max: 85). The mean numberof lymph nodes removed was 17.46 (±11.55), andthe mean number of positive lymph nodes was 3.48(±5.13). The mean duration of disease-free survival(DFS) was 65.2 (±46.07) months (min = 6, max =223). The mean overall survival time (OS) was 70.9(±44.4) months (min = 6, max = 223). In univariateanalysis, it was observed that as the LNR increased,recurrence and mortality increased statistically significantly(P < 0.001). According to the results of multivariateanalysis, the relationship of DFS and OS withthe LNR groups was statistically significant (P = 0.030and P = 0.019, respectively).ConclusionThe LNR in operated stage III CRC is an effectiveprognostic factor on DFS and OS.

AmaçKolorektal kanserler, tüm dünyada sık görülen ve mortalitesiyüksek kanserlerdendir. Bu kanserler ile ilgilibirçok prognostik faktör tanımlanmıştır. Bunlardan birtanesi de lenf nodu pozitiflik oranıdır. Bu çalışmanınamacı, Evre III kolorektal kanserlerde lenf nodu pozitiflikoranının prognostik önemini ortaya koymaktır.Gereç ve YöntemOcak 1998 ile Mayıs 2014 tarihleri arasında kolorektalkanser tanısı ile opere edilip adjuvan kemoterapialan, evre III hastaların kayıtları retrospektif olarak incelendi.Hastalar literatüre benzer şekilde lenf nodupozitiflik oranına göre 0-0,20 arası olanlar 1. grup,0,21-0,50 arası olanlar 2. grup ve 0,51-1 arası olanlar3. grup şeklinde üç gruba ayrıldı. Hastaların demografiközellikleri, çıkarılan pozitif ve toplam lenf nodusayısı, lenf nodu pozitiflik oranı, serbest tümör nodülüvarlığı ve sağ kalım verileri incelendi.BulgularÇalışmaya 263 hasta dâhil edildi. Hastaların 163’ü(%61,9) erkek iken, yaş ortanca değeri 62 (min:25-max:85) idi. Ortalama çıkarılan lenf nodu sayısı17.46 (±11.55) ve ortalama pozitif lenf nodu sayısı3.48 (±5.13) idi. Hastalıksız sağkalım süresi ortalama65,2(±46,07) ay (min=6, max=223) idi. Genel sağkalımsüresi ortalama 70,9 (±44,4) ay (min=6, max=223)idi. Hastalıksız sağkalım ve genel sağkalım ile lenfnodu grupları arasındaki ilişki tek değişkenli analizdeincelendiğinde; lenf nodu pozitiflik oranını arttıkçanüksün ve mortalitenin istatistiksel olarak anlamlı şekildearttığı gözlendi (p

Colorectal cancer Prognosis Lymph node ratio Adjuvant chemotherapy

Kolorektal kanser Prognoz Lenf nodu oranı Adjuvan kemoterapi

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