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Medical Journal of Süleyman Demirel University

2602-2109

Süleyman Demirel Üniversitesi

10.17343/sdutfd.1236410

Surgery

Cerrahi

ÖNEMİ BELİRSİZ ATİPİLİ HASTALARDAKİ POSTOPERATİF HİSTOPATOLOJİK MALİGNİTE VARLIĞI

PRESENCE OF POSTOPERATIVE HISTOPATHOLOGICAL MALIGNANCY IN PATIENTS WITH ATYPIA OF UNDETERMINED SIGNIFICANCE

https://orcid.org/0000-0002-0918-3208

Başçeken

Salim İlksen

Health Sciences University, Gazi Yaşargil Training and Research Hospital, Department of Surgical Oncology.

https://orcid.org/0000-0003-1759-2973

Tikici

Deniz

Health Sciences University, Gazi Yaşargil Training and Research Hospital, Department of Gastroenterological Surgery.

03 14 2023

30 1 119 122 01 16 2023 03 10 2023

1994

Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi

AmaçTiroid kanseri en sık görülen endokrin malignitesidirve klinik görünümü nodüllerle karakterizedir. Tiroidpatolojileri için yapılan biyopsilerde ‘Önemi belirsizatipi’ (ÖBA) literatürdeki farklı malignite oranları nedeniyleklinisyenler için önemli bir endişe kaynağıdır. Buçalışmada, AUS tanısı alan ve tiroid cerrahisi geçirenhastalarda malignite oranlarını güncel literatür ışığındasunmayı amaçladık.Gereç ve Yöntem2016-2021 yılları arasında kliniğimizde ince iğne aspirasyonbiyopsisinde (İİAB) ÖBA tanısı alan ve tiroidcerrahisi uygulanan 174 hastanın demografik ve histopatolojikverileri retrospektif olarak analiz edildi. Hastalarhistopatolojik özelliklerine göre malign ve benignolarak iki gruba ayrıldı. Gruplar arasındaki istatistikselanlamlılık Ki-kare ve Student t-testleri kullanılarak belirlenmiştir.P değeri 0.05).SonuçBethesda sınıflamasına göre ÖBA için malignite oranı%15-30 olarak belirtilmiştir. Çalışmamızda maligniteoranı, ülkemizde yapılan benzer çalışmalara benzerolarak, %43.5 saptanmıştır. ÖBA tanısıyla tiroid cerrahisiplanlanan vakalarda, yüksek malignite olasılığınedeniyle, lobektomiye alternatif olarak total tiroidektomide bir seçenek olarak düşünülmelidir.

ObjectiveThyroid cancer is the most common endocrineMalignancy, and nodules characterize its clinicalpresentation. 'Atypia of undetermined significance'(AUS) in biopsies performed for thyroid pathologiesis an essential concern for clinicians due to differentmalignancy rates in the literature. In this study, weaimed to discuss the malignancy rates in patients whounderwent thyroid surgery for AUS.Material and MethodThe demographic and histopathologic data of 174patients diagnosed with AUS on fine needle aspirationbiopsy (FNAB) and who underwent thyroid surgery inour clinic between 2016 and 2021 were retrospectivelyanalyzed. According to histopathologic features,patients were divided into two groups, malignantand benign, and the relationship with age, gender,and nodule diameter was investigated. Statisticalsignificance between groups was determined usingChi-square and Student t-tests. P value 0.05).ConclusionAccording to the Bethesda classification, themalignancy rate for AUS is 15-30%. In our study, themalignancy rate was 43.5%, similar to studies publishedin our country. Because of the high malignancyrate, total thyroidectomy should be considered analternative to lobectomy in cases planned for surgerywith a diagnosis of AUS.

ATA kılavuzu Bethesda sınıflaması İİAB Önemi belirsiz atipi Tiroid kanseri

ATA guideline Atypia of undetermined significance Bethesda Classification FNAB Thyroid malignancy

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