sdü tıp fak derg

Medical Journal of Süleyman Demirel University

2602-2109

Süleyman Demirel Üniversitesi

10.17343/sdutfd.1241625

Clinical Sciences

Klinik Tıp Bilimleri

INVESTIGATION OF THE RELATIONSHIP BETWEEN PLASMA APELIN LEVEL AND PRE-ECLAMPSIA CASES

PLAZMA APELİN DÜZEYİ VE PRE-EKLAMPSİ VAKALARI ARASINDAKİ BAĞLANTININ ARAŞTIRILMASI

https://orcid.org/0000-0001-8006-284X

Kocabaş

Rahim

Karamanoğlu Mehmetbey Üniversitesi Tıp Fakültesi

https://orcid.org/0000-0003-0008-2205

Geyik Bayman

Melike

https://orcid.org/0000-0002-2581-4938

Zeytin

Fatih

NECMETTİN ERBAKAN ÜNİVERSİTESİ, MERAM TIP FAKÜLTESİ, TEMEL TIP BİLİMLERİ BÖLÜMÜ, TIBBİ BİYOKİMYA ANABİLİM DALI

https://orcid.org/0000-0001-6733-2497

Karabulut

Ercan

ANKARA YILDIRIM BEYAZIT ÜNİVERSİTESİ, TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, TIBBİ FARMAKOLOJİ ANABİLİM DALI, KLİNİK FARMAKOLOJİ BİLİM DALI

https://orcid.org/0000-0003-2748-5493

Aköz

Mehmet

NECMETTİN ERBAKAN ÜNİVERSİTESİ, MERAM TIP FAKÜLTESİ, TEMEL TIP BİLİMLERİ BÖLÜMÜ, TIBBİ BİYOKİMYA ANABİLİM DALI

06 22 2023

30 2 211 216 01 24 2023 05 24 2023

1994

Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi

ObjectivePre-eclampsia, a multi-systemic disease that developsduring pregnancy, is a pathology that causes atleast 42.000 maternal deaths per year. Theoriesregarding the pathophysiology of pre-eclampsia aremainly based on maternal-fetal (paternal) immunemalperfusion, which is thought to be associatedwith superficial placentation, and the cause of preeclampsiahas not yet been fully elucidated. Apelin isa peptide that affects blood pressure regulation andvascular functions, and also has various physiologicalfunctions. In this study, plasma apelin-13 levels werestudied in normal and development of early-onsetpre-eclampsia pregnant women to evaluate whetherapelin-13 has a role in the development of early-onsetpre-eclampsia.Material and MethodIn this case-control prospective study, a total of 60pregnant women who applied to the Obstetrics andGynecology Service were included in the study.The groups in the project were designed as healthypregnant control (n: 30) and the development ofearly-onset pre-eclampsia pregnant (n: 30). Thedevelopment of early-onset pre-eclampsia groupconsisted of the development of early-onset preeclampsiapregnant women diagnosed with preeclampsiaat the 30th week. Platelet, serum albumin,ALT, AST, urea, creatinine and plasma apelin-13values were measured from the blood samples takenfrom the participants at the 30th week.ResultsCompared to healthy pregnant controls, the decreasesin platelet and serum albumin levels, and the increasesin ALT, AST, urea, and creatinine parameters in thedevelopment of early-onset pre-eclampsia pregnantwomen were statistically significant (p=0,011;p=0,001; p=0,006; p=0,05; p=0,001; p=0,003;respectively). When the plasma apelin-13 value wascompared between healthy and the developmentof early-onset pre-eclampsia pregnant women, nosignificant difference was found.ConclusionApelin-13 has no diagnostic value in the diagnosis ofdevelopment of early-onset pre-eclampsia developingafter the 30th week.

AmaçGebelikte gelişen ve multi-sistemik bir hastalık olanpre-eklampsi, yılda en az 42.000 anne ölümüne sebepolan bir patolojidir. Pre-eklampsi patofizyolojisineilişkin teoriler, temel olarak yüzeysel plasentasyon ileilişkili olduğu düşünülen maternal-fetal immün malperfüzyonadayanmakta ve pre-eklampsinin nedeniise henüz tam olarak aydınlatılamamıştır. Apelin, kanbasıncı regülasyonu ve vasküler fonksiyonları etkileyen,ayrıca çeşitli fizyolojik görevleri olan bir peptittir.Bu çalışmada, pre-eklampsi gelişiminde apelin-13’ünrolünün olup olmadığını değerlendirmek amacıylanormal ve erken başlangıçlı pre-eklampsili gebelerde,plazma apelin-13 seviyeleri çalışıldı.Gereç ve YöntemBu vaka kontrol prospektif çalışma, Kadın Hastalıklarıve Doğum Servisine başvuran gebelerin içerisindetoplam 60 gebe çalışmaya dahil edildi. Projedekigruplar sağlıklı gebe kontrol (n:30) ve erken başlangıçlıpre-eklampsi gebe (n:30) olarak dizayn edildi.Erken başlangıçlı pre-eklampsi grubu 30. haftadapre-eklampsi tanısı konan erken başlangıçlı pre-eklampsigebelerden oluşmakta idi. Katılımcılardan 30.hafta alınan kan örneklerinden trombosit, serum albümin,ALT, AST, üre, kreatinin ve plazma apelin-13değerleri ölçüldü.BulgularSağlıklı gebe kontrollere göre, erken başlangıçlıpre-eklampsi gebelerdeki trombosit, serum albümin,seviyelerindeki azalma ve ALT, AST, üre ve kreatininparametrelerindeki artma, istatiksel değerlendirmeaçısından anlamlı bulundu (p=0,011; p=0,001;p=0,006; p=0,05; p=0,001; p=0,003; sırasıyla). Plazmaapelin-13 değeri sağlıklı ve erken başlangıçlıpre-eklampsi gebeler arasında karşılaştırıldığında anlamlıbir fark bulunmadı.Sonuç30. haftadan sonra gelişen erken başlangıçlı pre-eklampsininteşhisinde Apelin-13’ün tanısal değeri bulunmamaktadır.

Apelin Apelin 13 Gebelik Hipertansiyon Pre-eklampsi.

Apelin Apelin 13 Hypertension Preeclampsia Pregnancy

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