sdü tıp fak derg Medical Journal of Süleyman Demirel University 2602-2109 Süleyman Demirel Üniversitesi 10.17343/sdutfd.1329050 Periodontics Neurology and Neuromuscular Diseases Periodontoloji Nöroloji ve Nöromüsküler Hastalıklar Multipl Skleroz Hastalarında Tükürük Tiyol-Disülfit Homeostazisinin Değerlendirilmesi Periodontal Health and Salivary Thiol-Disulphide Homeostasis in Multiple Sclerosis Patients https://orcid.org/0000-0002-5240-4504 Kırzıoğlu Fatma Yeşim Süleynman Demirel Üniversitesi, Diş Hekimliği Fakültesi, Periodontoloji A.D. https://orcid.org/0000-0003-1561-1296 Demirci Serpil SÜLEYMAN DEMİREL ÜNİVERSİTESİ, TIP FAKÜLTESİ https://orcid.org/0000-0002-4241-3415 Varol Çağla https://orcid.org/0000-0002-4424-044X Doğan Ünlü Melike SÜLEYMAN DEMİREL ÜNİVERSİTESİ, TIP FAKÜLTESİ https://orcid.org/0000-0002-9567-7270 Calapoğlu Mustafa SÜLEYMAN DEMİREL ÜNİVERSİTESİ, FEN-EDEBİYAT FAKÜLTESİ https://orcid.org/0000-0002-8389-1069 Orhan Hikmet SÜLEYMAN DEMİREL ÜNİVERSİTESİ, TIP FAKÜLTESİ 06 29 2024 31 2 125 133 07 19 2023 05 17 2024 Copyright © 1994, Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi 1994 Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi

Amaç: Multipl skleroz (MS), patolojisinde nöroinflamasyon ve oksidatif stresin önemli rol oynadığı kronik otoimmün bir hastalıktır. Tiyol-disülfit homeostazı, oksidatif stresin bir belirteci olarak kabul edilir ve MS de dahil olmak üzere birçok hastalıktan etkilendiği gösterilmiştir. Bu çalışmanın amacı, MS hastalarında tükürük disülfit ve tiyol düzeylerini belirlemek ve sistemik olarak sağlıklı kontrollerle karşılaştırmak ve periodontal durumun tükürükte tiyol-disülfit homeostazı üzerine etkisinin olup olmadığını değerlendirmektir.Gereç ve Yöntemler: Tanımlayıcı tipteki bu çalışmaya 92 MS hastası ve 92 sistemik olarak sağlıklı gönüllü olmak üzere toplam 184 gönüllü dahil edildi. Her bireye tıbbi, nörolojik ve sözlü muayene yapıldı. Tükürük örneklerinde nativ tiyol (NT), total tiyol (TT), disülfit düzeyleri ölçüldü. NT/TT, disülfit/NT, D/TT oranları hesaplandı ve hasta ve kontrol grupları arasında karşılaştırıldı.Bulgular: MS ve sağlıklı gönüllüler arasında periodontal parametreler açısından herhangi bir fark yoktu (P>0.05), ancak tükürükteki tiyol-disülfit homeostazının biyobelirteçleri, TT hariç, gruplar arasında anlamlı derecede farklıydı (P0.05), MS hastalarında sağlıklı gönüllülere göre NT/TT'de azalma ve disülfit/NT oranlarında artış (P

Objective: Multiple sclerosis (MS) is a chronic autoimmune disease in which neuroinflammation and oxidative stress play important roles in its pathology. Thiol-disulphide homeostasis is considered a marker of oxidative stress and shown to be affected in several disorders including MS. The aim of this study was to compare salivary disulfide and thiol levels in MS patients with systemically healthy controls and to evaluate whether periodontal status had an effect on thiol-disulfide homeostasis in saliva.Material and Method: This descriptive study included a total of 184 volunteers, 92 with MS and 92 systemically healthy volunteers. Each person underwent medical, neurological and oral examinations. In saliva samples, native thiol (NT), total thiol (TT), disulphide levels were measured. The ratios of NT/TT, disulphide/NT, D/TT were calculated and compared between the patient and control groups.Results: There was not any difference in the periodontal parameters between the MS and healthy volunteers (p>0.05), however, the biomarkers of thiol-disulphide homeostasis in saliva were significantly different between the groups (p0.05), MS patients showed decreased NT/TT and increased disulphide/NT ratios compared to the healthy volunteers (p

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