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            <front>

                <journal-meta>
                                                                <journal-id>sdü tıp fak derg</journal-id>
            <journal-title-group>
                                                                                    <journal-title>Medical Journal of Süleyman Demirel University</journal-title>
            </journal-title-group>
                                        <issn pub-type="epub">2602-2109</issn>
                                                                                            <publisher>
                    <publisher-name>Süleyman Demirel Üniversitesi</publisher-name>
                </publisher>
                    </journal-meta>
                <article-meta>
                                        <article-id pub-id-type="doi">10.17343/sdutfd.1348270</article-id>
                                                                <article-categories>
                                            <subj-group  xml:lang="en">
                                                            <subject>Clinical Sciences (Other)</subject>
                                                    </subj-group>
                                            <subj-group  xml:lang="tr">
                                                            <subject>Klinik Tıp Bilimleri (Diğer)</subject>
                                                    </subj-group>
                                    </article-categories>
                                                                                                                                                        <title-group>
                                                                                                                        <article-title>ARI VENOMUNA BAĞLI ANAFİLAKSİ: KLİNİK DENEYİMİMİZ</article-title>
                                                                                                                                                                                                <trans-title-group xml:lang="en">
                                    <trans-title>HYMENOPTERA VENOM-INDUCED ANAPHYLAXİS: OUR CLİNİCAL EXPERİENCE</trans-title>
                                </trans-title-group>
                                                                                                    </title-group>
            
                                                    <contrib-group content-type="authors">
                                                                        <contrib contrib-type="author">
                                                                    <contrib-id contrib-id-type="orcid">
                                        https://orcid.org/0000-0002-2053-4638</contrib-id>
                                                                <name>
                                    <surname>Akçam</surname>
                                    <given-names>Nurullah Yekta</given-names>
                                </name>
                                                                    <aff>MERSİN ŞEHİR HASTANESİ</aff>
                                                            </contrib>
                                                    <contrib contrib-type="author">
                                                                    <contrib-id contrib-id-type="orcid">
                                        https://orcid.org/0000-0003-4467-9652</contrib-id>
                                                                <name>
                                    <surname>Kırmızıtaş Aydoğdu</surname>
                                    <given-names>Ayşe</given-names>
                                </name>
                                                                    <aff>Mersin Şehir Eğitim ve Araştırma Hastanesi</aff>
                                                            </contrib>
                                                                                </contrib-group>
                        
                                        <pub-date pub-type="pub" iso-8601-date="20230923">
                    <day>09</day>
                    <month>23</month>
                    <year>2023</year>
                </pub-date>
                                        <volume>30</volume>
                                        <issue>3</issue>
                                        <fpage>562</fpage>
                                        <lpage>571</lpage>
                        
                        <history>
                                    <date date-type="received" iso-8601-date="20230822">
                        <day>08</day>
                        <month>22</month>
                        <year>2023</year>
                    </date>
                                                    <date date-type="accepted" iso-8601-date="20230920">
                        <day>09</day>
                        <month>20</month>
                        <year>2023</year>
                    </date>
                            </history>
                                        <permissions>
                    <copyright-statement>Copyright © 1994, Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi</copyright-statement>
                    <copyright-year>1994</copyright-year>
                    <copyright-holder>Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi</copyright-holder>
                </permissions>
            
                                                                                                <abstract><p>AmaçArı alerjileri en sık anafilaksi nedenlerindendir veşiddetli anafilaksi ile karakterizedir. Amacımız arı venomunabağlı anafilaksi geçiren erişkin olgularda reaksiyonayol açan arı türleri ile gelişen anafilaksininşiddeti, in-vivo ve in-vitro test sonuçları ile olgularındemografik özelliklerini araştırmaktır.Gereç ve YöntemMart 2017- Haziran 2022 tarihleri arasında kliniğimizdearı alerjisine bağlı sistemik reaksiyon nedeniyletakipli ve Amerikan Ulusal Alerji ve Enfeksiyon HastalıklarıEnstitüsü (National Institutes of Allergy and InfectiousDisease, NIAID) ile Besin Alerjileri ve AnafilaksiAğı (Food Allergy and Anaphylaxis Network, FAAN)tarafından 2006 yılında geliştirilen ölçütlere göre anafilaksikriterlerine uyan olgular alındı. Arı türü, bazaltriptaz, Total IgE ve venom spesifik IgE düzeyleri, deritesti sonuçları kaydedildi. Anafilaksi şiddeti Mueller kriterlerinegöre skorlandı. Ataklarda adrenalin kullanımı,adrenalin otoenjektörü bulundurma değerlendirildi.BulgularToplam 102 arı ilişkili anafilaksi olgusundan %53,9’ununerkek olup ortalama yaşın 44.8 olduğu saptandı. Arıtürü açısından %69,6 olguda bal arısı (Apidae), %19,6olguda yaban arısı (Vespidae), %10,8 olguda ise heriki türle anafilaksi geliştiği belirlendi. Anafilaksi şiddetiMueller sınıflanmasına göre %10,7 olgu Grade I,%58,8 Grade II, %27,45 Grade III, %2,91 ise Grade IVile uyumluydu. Atak sıklığı açısından 20 olgu tek atak,37 olgu 2, 42 olgu ise 3 veya daha fazla anafilaksiatağı geçirdiği belirlendi. Hastaların %44,11’inde atopisaptandı. Yaş, cinsiyet, atopik durum, kronik hastalıkbirlikteliği, ek ilaç kullanımı ve kanda eosinofil, totalIgE düzeyleri ile reaksiyon şiddeti arasında anlamlı birilişki saptanmadı. Hastaların %80,4’üne adrenalin otoenjektörreçetelenmesine rağmen tedavide adrenalinkullanım oranı %31,4 saptandı.SonuçArı venom ilişkili anafilakside olguların çoğu birdenfazla atak geçirmesine rağmen tedavide adrenalin kullanımoranları düşük seviyelerde kalmaktadır. En sıkanafilaksi bal arısı sokmasına bağlı olarak gelişirkenerkek cinsiyette riskin daha fazla olduğu saptandı</p></abstract>
                                                                                                                                    <trans-abstract xml:lang="en">
                            <p>ObjectiveVenom allergies are the most common cause ofanaphylaxis in adults and are characterized by severeanaphylaxis. We aim to investigate the relationshiprebetweenthe bee species causing the reaction and theseverity of anaphylaxis, in-vivo and in-vitro test resultsand demographic characteristics of the cases in adultpatients who were treated in the allergy clinic for beevenom-related anaphylaxis.Material and MethodPatients who developed systemic reaction due to beevenom allergy in the adult allergy clinic between March2017 and June 2022 meeting the National Institutesof Allergy and Infectious Disease (NIAID) and FoodAllergy and Anaphylaxis Network (FAAN) anaphylaxiscriteria were included in the study. Demographic andclinical data (tryptase, total IgE, bee venom specificIgE levels and skin test) of all cases were evaluated.Anaphylaxis severity was scored according to the Muellercriteria. Adrenaline use in attacks and carryingan adrenaline auto-injector were evaluated.ResultsAmong 102 cases, 53.9% were men and mean agewas 44.80 years. It was determined that anaphylaxisdeveloped with honeybee in 69.60%, wasps in19.6%, and both species in 10.8%. The severity ofanaphylaxis, according to Mueller classification wereas follows: 10.7% Grade-I, 58.8% Grade-II, 27.45%Grade-III and Grade-IV 2.91%. In terms of attackfrequency, it was determined that 20 patients had asingle attack; 37 patients had 2 and 42 patients had3 or more anaphylaxis attacks. Atopy was detected in44.11% of the patients. No significant correlation wasfound between age, gender, atopic status, chronicdisease coexistence, additional drug use, eosinophillevels, TIgE levels and the severity of the reaction.Although 80.4% of the patients were prescribed anadrenaline autoinjector, the rate of its usage in the treatmentof attacks was 31.4%.ConclusionMost of the patients suffering from bee venom-inducedanaphylaxis had a history of more than one attack.The rates of adrenaline use in emergency treatmentstill remain at low levels. In our study, honeybees arethe most responsible type of bee; the males appear tobe at a greater risk as compared to females.</p></trans-abstract>
                                                            
            
                                                            <kwd-group>
                                                    <kwd>Anafilaksi</kwd>
                                                    <kwd>  epinefrin</kwd>
                                                    <kwd>  risk faktörleri</kwd>
                                                    <kwd>  arı venom alerjisi</kwd>
                                            </kwd-group>
                                                        
                                                                            <kwd-group xml:lang="en">
                                                    <kwd>Anaphylaxis</kwd>
                                                    <kwd>  epinephrine</kwd>
                                                    <kwd>  risk factors</kwd>
                                                    <kwd>  bee venom allergy</kwd>
                                            </kwd-group>
                                                                                                            </article-meta>
    </front>
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