sdü tıp fak derg Medical Journal of Süleyman Demirel University 2602-2109 Süleyman Demirel Üniversitesi 10.17343/sdutfd.1371727 Cell Development, Proliferation and Death Hücre Gelişimi, Proliferasyon ve Ölümü KUPROPTOZ; BAKIR İLİŞKİLİ HÜCRE ÖLÜM YOLAĞI CUPROPTOSIS; COPPER ASSOCIATED CELL DEATH PATHWAY https://orcid.org/0009-0006-8236-8598 Aksu Ebru Nur MUĞLA SITKI KOÇMAN ÜNİVERSİTESİ https://orcid.org/0000-0002-9715-1424 Sakallı Esin MUĞLA SITKI KOÇMAN ÜNİVERSİTESİ 12 30 2023 30 4 764 770 10 05 2023 11 13 2023 Copyright © 1994, Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi 1994 Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi

Farklı organlarda ve metabolik süreçlerde yer alan enzimler için bir kofaktör olan bakır (Cu), hücresel ve fizyolojik insan sağlığı için gerekli olan önemli mikro besinlerden biridir. Son yıllarda hücrelerde biriken bakırın mitokondriyal solunum ve lipoik asit (LA) yolu ile ilişkili ve proteotoksik stres ile karakterize, “kuproptoz” olarak adlandırılan yeni bir programlı ölüm şekli tanımlanmıştır. Kuproptoz mekanizmasının daha iyi anlaşılmasına yönelik çalışmalar devam etmekle birlikte birçok araştırmacı da kuproptoz ve kanserin farklı özellikleri arasındaki ilişkiyi ortaya koymak amacıyla araştırmalarını sürdürmektedir. Bu derleme hücresel ve fizyolojik Cu metabolizmasına, kuproptoz mekanizmasına ve çeşitli kanser türleri ile olan ilişkisine odaklanmaktadır.

Copper (Cu) is an essential micronutrient for human cellular and physiological health since it acts as a cofactor for enzymes involved in various metabolic processes throughout different organs in the body. Recently, a new type of programmed cell death, known as "cuproptosis," has been discovered and linked to mitochondrial respiration and the lipoic acid (LA) pathway. Cuproptosis is characterised by proteotoxic stress resulting from the gradual accumulation of copper in cells. Although researchers continue to study the mechanism of cuproptosis, the relationship between cuproptosis and different features of cancer is still being explored. This review examines cellular and physiological copper metabolism, the cuproptosis mechanism, and its associations with various types of cancer.

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